Rationale and design of the MarrowStim PAD Kit for the Treatment of Critical Limb Ischemia in Subjects with Severe Peripheral Arterial Disease (MOBILE) trial investigating autologous bone marrow cell therapy for critical limb ischemia

• Published in: Journal of vascular surgery Vol. 65; no. 6; pp. 1850 - 1857.e2
• Main Authors: Wang, S. Keisin, Green, Linden A., Motaganahalli, Raghu L., Wilson, Michael G., Fajardo, Andres, Murphy, Michael P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2017
• Subjects: Ankle Brachial Index; Blood Gas Monitoring, Transcutaneous; Bone Marrow Transplantation - adverse effects; Bone Marrow Transplantation - methods; Cell Separation - instrumentation; Clinical Protocols; Critical Illness; Double-Blind Method; Equipment Design; Humans; Injections, Intramuscular; Ischemia - diagnosis; Ischemia - physiopathology; Ischemia - surgery; Lower Extremity - blood supply; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - physiopathology; Peripheral Arterial Disease - surgery; Research Design; Severity of Illness Index; Surgery; Time Factors; Transplantation, Autologous; Treatment Outcome

Critical limb ischemia (CLI) continues to place a significant encumbrance on patients and the health care system as it progresses to limb loss and long-term disability. Traditional methods of revascularization offer a significant benefit; however, for one-third of CLI patients, these surgical option...