Microbial production of sialic acid and sialylated human milk oligosaccharides: Advances and perspectives

• Published in: Biotechnology advances Vol. 37; no. 5; pp. 787 - 800
• Main Authors: Zhang, Xiaolong, Liu, Yanfeng, Liu, Long, Li, Jianghua, Du, Guocheng, Chen, Jian
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2019; Elsevier Science Ltd
• Subjects: Acids; allergens; Baby foods; Bacillus subtilis; biochemical pathways; Biology; Biosynthesis; Brain; breast milk; Catalysis; catalytic activity; cell growth; Chemical synthesis; food additives; functional foods; Functional foods & nutraceuticals; Humans; Immunity; infant development; Lactose - analogs & derivatives; Lactose - biosynthesis; Lactose - metabolism; Metabolic engineering; Metabolic Engineering - methods; Metabolism; Microorganisms; Microorganisms, Genetically-Modified - metabolism; Milk, Human - chemistry; Milk, Human - metabolism; N-acetylneuraminic acid; N-Acetylneuraminic Acid - biosynthesis; Oligosaccharides; Oligosaccharides - metabolism; Sialic acid; Sialic Acids - biosynthesis; Sialylated human milk oligosaccharides; Sugar; supply balance; Synthetic biology; Synthetic Biology - economics; Synthetic Biology - methods; thermodynamics; Metabolic engineering; Sialic acid; Synthetic biology; Sialylated human milk oligosaccharides; Bacillus subtilis; N-acetylneuraminic acid

Sialic acids (SAs) are important functional sugars, and monomers of sialylated human milk oligosaccharides (sialylated HMOs or sialyllactoses), which are crucial for improving infant development and can facilitate infant brain development, maintain brain health, and enhance immunity. The most common...