Prognostic Value of Sex-Hormone Receptor Expression in Non-Muscle-Invasive Bladder Cancer

• Published in: Yonsei medical journal Vol. 55; no. 5; pp. 1214 - 1221
• Main Authors: Nam, Jong Kil, Park, Sung Woo, Lee, Sang Don, Chung, Moon Kee
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.09.2014; 연세대학교의과대학
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - metabolism; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Disease Progression; Disease-Free Survival; Female; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Original; Prognosis; Receptors, Androgen - metabolism; Receptors, Estrogen - metabolism; Retrospective Studies; Risk Factors; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Young Adult; 의학일반; estrogen receptor beta; urinary bladder neoplasms; Androgen receptor
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2014.55.5.1214

We investigated sex-hormone receptor expression as predicting factor of recurrence and progression in patients with non-muscle invasive bladder cancer. We retrospectively evaluated tumor specimens from patients treated for transitional cell carcinoma of the bladder at our institution between January 2006 and January 2011. Performing immunohistochemistry using a monoclonal androgen receptor antibody and monoclonal estrogen receptor-beta antibody on paraffin-embedded tissue sections, we assessed the relationship of immunohistochemistry results and prognostic factors such as recurrence and progression. A total of 169 patients with bladder cancer were evaluated in this study. Sixty-threepatients had expressed androgen receptors and 52 patients had estrogen receptor beta. On univariable analysis, androgen receptor expression was significant lower in recurrence rates (p=0.001), and estrogen receptor beta expression was significant higher in progression rates (p=0.004). On multivariable analysis, significant association was found between androgen receptor expression and lower recurrence rates (hazard ratio=0.500; 95% confidence interval, 0.294 to 0.852; p=0.011), but estrogen receptor beta expression was not significantly associated with progression rates. We concluded that the possibility of recurrence was low when the androgen receptor was expressed in the bladder cancer specimen and it could be the predicting factor of the stage, number of tumors, carcinoma in situ lesion and recurrence.