An efficient approach to prepare sulfated polysaccharide and evaluation of anti-tumor activities in vitro

• Published in: Carbohydrate polymers Vol. 184; pp. 366 - 375
• Main Authors: Wang, Junlong, Bao, Aijuan, Meng, Xinhua, Guo, Hongyun, Zhang, Yongdong, Zhao, Yali, Kong, Weibao, Liang, Junyu, Yao, Jian, Zhang, Ji
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.03.2018
• Subjects: A549 Cells; Anti-tumor activity; antineoplastic activity; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Artemisia sphaerocephala; cell cycle; Cell Cycle - drug effects; chemical structure; chromatography; Fourier transform infrared spectroscopy; Hep G2 Cells; hepatoma; human cell lines; Humans; lung neoplasms; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microwave assisted synthesis; microwave radiation; microwave treatment; Microwaves; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; photometers; polysaccharides; Polysaccharides - chemical synthesis; Polysaccharides - chemistry; Polysaccharides - pharmacology; pyridines; solvents; Sulfation; uterine cervical neoplasms; Anti-tumor activity; Microwave assisted synthesis; Sulfation

•Microwave-assisted synthesis of sulfated polysaccharide was highly effective and characterized by time saving and high DS.•Short reaction time minimized acid-catalyzed degradation of polysaccharide chains.•MW and molecular distribution had much greater influence on anti-tumor activities of SPAS aga...