Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics - Brennan, Meghan; Williams, J. Andrew; Chen, Ying; Tortorici, Michael; Pithavala, Yazdi; Liu, Yingxue Cathy (European journal of clinical pharmacology, 2012)
Keywords: Angiogenesis Inhibitors - blood; Angiogenesis Inhibitors - pharmacokinetics; Biological and medical sciences; Biological Transport; Biomedical and Life Sciences; Biomedicine; Biotransformation; Clinical trials; Clinical Trials, Phase I as Topic; CYP1A2 protein; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Data processing; Drugs; Enzymes; Gene polymorphism; Genetics; Humans; Imidazoles - blood; Imidazoles - pharmacokinetics; Indazoles - blood; Indazoles - pharmacokinetics; Inhibitor drugs; Isoenzymes - genetics; Isoenzymes - metabolism; Medical sciences; Meta-analysis; Oral administration; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; P-Glycoprotein; Pharmacogenetics; Pharmacokinetics; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Polymorphism; Polymorphism, Genetic; Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors; Reviews; Statistical analysis; Statistics; UDP-glucuronosyltransferase; Vascular endothelial growth factor; Axitinib; Single-nucleotide polymorphism; Pharmacokinetics; Variability; Pharmacogenomics; Meta-analysis; Antineoplastic agent; Human; Genetic variability; Enzyme; Tyrosine kinase inhibitor; Genomics; Genotype; s Axitinib; Metaanalysis; Genetics; Drug-metabolizing enzyme; Single nucleotide polymorphism; Carrier protein