Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities

• Published in: Journal of allergy and clinical immunology Vol. 147; no. 4; pp. 1369 - 1380
• Main Authors: He, Helen, Del Duca, Ester, Diaz, Aisleen, Kim, Hyun Je, Gay-Mimbrera, Jesús, Zhang, Ning, Wu, Jianni, Beaziz, Jessica, Estrada, Yeriel, Krueger, James G., Pavel, Ana B., Ruano, Juan, Guttman-Yassky, Emma
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2021; Elsevier Limited
• Subjects: Age; Arteriosclerosis; Atherosclerosis; Atopic dermatitis; Biopsy; Cardiovascular disease; Cardiovascular diseases; CCL17 protein; CCL20 protein; Cell activation; CXCL10 protein; cytokines; Dendritic cells; Dermatitis; Eczema; Foxp3 protein; Gene expression; Helper cells; Hyperplasia; Hypothesis testing; immune tolerance; Immunohistochemistry; Inflammation; Insulin-like growth factor-binding protein 1; Interleukin 1; Interleukin 10; Interleukin 13; Interleukin 22; limited; Lymphocytes T; mild; OLINK; Patients; Proteomics; Psoriasis; qRT-PCR; severity; Skin; Skin diseases; Skin lesions; Software; systemic inflammation; severity; CXCL; SCORAD; IGA; AD; proteomics; limited; mild; qRT-PCR; Treg; OSM; HR; CCL; systemic inflammation; BSA; immune tolerance; Atopic dermatitis; OLINK; cytokines; DC

Molecular studies in atopic dermatitis (AD) are largely restricted to patients with moderate-to-severe disease. Our aim was to evaluate skin and blood abnormalities in mild, moderate, and severe AD. Skin and blood samples were obtained from 61 patients with AD (20 with mild or limited disease, 17 wi...