LC-MS/MS method for proline-glycine-proline and acetylated proline-glycine-proline in human plasma

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1228; p. 123815
• Main Authors: Tiwary, Ekta, Berryhill, Taylor F, Wilson, Landon, Barnes, Stephen, Prasain, Jeevan K, Wells, J Michael
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2023
• Subjects: acetonitrile; AcPGP; biomarkers; chemical species; chromatography; Chromatography, Liquid; Collagen; COPD; detection limit; elastin; freeze-thaw cycles; Glycine; heart diseases; Humans; inflammation; isotope dilution technique; LC-MS/MS; Matrikines; metalloproteinases; Method Development; Peptides; PGP; Plasma; Proline; respiratory tract diseases; Tandem Mass Spectrometry; therapeutics; LC-MS/MS; Plasma; Matrikines; AcPGP; PGP; Method Development; COPD

The extracellular cellular matrix (ECM) maintains tissue structure and regulates signaling functions by continuous degradation and remodeling. Inflammation or other disease conditions activate proteases including matrix metalloproteinases (MMPs) that degrade ECM proteins and in particular generate f...