Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 6; pp. 1886 - 1891
• Main Authors: Gao, Caiji, Zhuang, Xiaohong, Cui, Yong, Fu, Xi, He, Yilin, Zhao, Qiong, Zeng, Yonglun, Shen, Jinbo, Luo, Ming, Jiang, Liwen
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.02.2015; National Acad Sciences
• Subjects: Arabidopsis; Arabidopsis - genetics; Arabidopsis - physiology; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Autophagy; Autophagy - physiology; biogenesis; Biological Sciences; Biosynthesis; Carrier Proteins - genetics; Carrier Proteins - metabolism; Degradation; Endosomal Sorting Complexes Required for Transport - metabolism; Flowers & plants; Fluorescence Resonance Energy Transfer; lysosomes; Microscopy, Confocal; Microscopy, Electron, Transmission; Multivesicular Bodies - metabolism; Photobleaching; Plant growth; Protein Transport - genetics; Protein Transport - physiology; Proteins; transport proteins; vacuoles; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism; FYVE domain; ESCRT machinery; autophagic degradation; FREE1; vacuole biogenesis

Protein turnover can be achieved via the lysosome/vacuole and the autophagic degradation pathways. Evidence has accumulated revealing that efficient autophagic degradation requires functional endosomal sorting complex required for transport (ESCRT) machinery. However, the interplay between the ESCRT...