The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young and aging male mice

• Published in: Neurobiology of aging Vol. 126; pp. 77 - 90
• Main Authors: Brunswick, Chad A., Baldwin, Derek J., Bodinayake, Kasuni K., McKenna, Alexandria R., Lo, Chen-Yu, Bellfy, Lauren, Urban, Mark W., Stuart, Emily M., Murakami, Shoko, Smies, Chad W., Kwapis, Janine L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2023
• Subjects: Aging; Aging - genetics; Animals; Brain - metabolism; Circadian Clocks - genetics; Circadian Rhythm - genetics; Cognitive decline; Gyrus Cinguli - metabolism; Incidental learning; Male; Mice; Per1; Period Circadian Proteins - genetics; Period Circadian Proteins - metabolism; Retrosplenial cortex; Suprachiasmatic nucleus; Suprachiasmatic Nucleus - metabolism; Transcription Factors - metabolism; Suprachiasmatic nucleus; TTFL; RSC; DH; BMAL; HSV; IEG; Cry; Incidental learning; Cognitive decline; Per1; OLM; CREB; sgRNA; Aging; Retrosplenial cortex; ZT; CLOCK; SCN

•Learning induces Per1 expression within the RSC of young and aging mice.•This RSC Per1 induction rhythmically cycles in young and aging mice.•Bidirectional RSC Per1 manipulations affect spatial memory.•Learning also induces Per1 within the SCN of young (but not aging) mice.•Per1 knockdown in the SC...