IL-17A secreted from lymphatic endothelial cells promotes tumorigenesis by upregulation of PD-L1 in hepatoma stem cells

• Published in: Journal of hepatology Vol. 71; no. 6; pp. 1206 - 1215
• Main Authors: Wei, Yuanyan, Shi, Danfang, Liang, Ziwei, Liu, Yuming, Li, Yinan, Xing, Yang, Liu, Weitao, Ai, Zhilong, Zhuang, Jianhui, Chen, Xiaoning, Gao, Qiang, Jiang, Jianhai
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019; Elsevier Science Ltd
• Subjects: AC133 Antigen - immunology; B7-H1 Antigen - immunology; Carcinogenesis - metabolism; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; CD133; Cell Line, Tumor; Cell self-renewal; Cell Transformation, Neoplastic; Endothelial cells; Endothelial Cells - immunology; Endothelial Cells - metabolism; Flow cytometry; Hepatocytes; Hepatoma; Hepatoma stem cell; Humans; Immune escape; Immunofluorescence; Immunohistochemistry; Interleukin-17 - immunology; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Lymphatic endothelial cell; Mannose; N-glycans; Neoplastic Stem Cells - metabolism; PD-L1 protein; Polysaccharides; Reverse transcription; Signal Transduction; Stem cells; Tumor Escape; Tumor Microenvironment; Tumorigenesis; Up-Regulation; Xenograft Model Antitumor Assays; Hepatoma stem cell; Immune escape; Lymphatic endothelial cell; CD133

[Display omitted] •Hepatoma stem cells preferentially interact with lymphatic endothelial cells.•Interaction of hepatoma stem cells with lymphatic endothelial cells upregulates IL-17A.•IL-17A promotes hepatoma stem cell self-renewal and immune escape.•IL-17A is highly expressed in hepatoma. The micr...