Upregulation of H(+)-peptide cotransporter PEPT2 in rat remnant kidney

• Published in: American journal of physiology. Renal physiology Vol. 281; no. 6; pp. F1109 - F1116
• Main Authors: Takahashi, K, Masuda, S, Nakamura, N, Saito, H, Futami, T, Doi, T, Inui, K
• Format: Journal Article
• Language: English
• Published: United States 01.12.2001
• Subjects: Animals; Biological Transport; Blotting, Western; Carrier Proteins - genetics; Carrier Proteins - metabolism; Dipeptides - metabolism; Glucose - metabolism; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - physiopathology; Kinetics; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Microvilli - metabolism; Monosaccharide Transport Proteins - genetics; Monosaccharide Transport Proteins - metabolism; Nephrectomy; Peptide Transporter 1; Rats; Rats, Wistar; RNA, Messenger - biosynthesis; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Symporters - biosynthesis; Symporters - genetics; Up-Regulation

The progression of renal damage resulting from reduced nephron mass has been extensively studied in the 5/6 nephrectomized rat. However, reabsorption of small peptides and D-glucose across the renal proximal tubule in this model remains poorly understood. In this study, we examined the alterations o...