Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin-Induced Nephrotoxicity In Vivo and In Vitro

• Published in: Kidney & blood pressure research Vol. 41; no. 6; pp. 911 - 918
• Main Authors: Luo, Qi-Hui, Chen, Meng-Lu, Chen, Zheng-Li, Huang, Chao, Cheng, An-Chun, Fang, Jing, Tang, Li, Geng, Yi
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger Publishers 01.01.2016
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - chemically induced; Acute Kidney Injury - diagnosis; Acute-Phase Proteins; Animals; Biomarkers - blood; Cell Adhesion Molecules - blood; Cell Line; Gene Expression Regulation - drug effects; Gentamicins - toxicity; Gentamycin; HK-2 cells; Humans; KIM-1; Lipocalins - blood; Male; Nephrotoxicity; NGAL; Original Paper; Proto-Oncogene Proteins - blood; Rats; Rats, Sprague-Dawley; KIM-1; NGAL; Nephrotoxicity; HK-2 cells; Gentamycin

Background/Aims: The aminolycoside Gentamicin is a widely used antibiotic, applied in equine medicine. Despite its clinical use, concerns remain regarding the potential toxic side-effects, such as nephrotoxicity. Early detection of renal damage is critical in preclinical drug development. This study...