Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex

• Published in: Cell Vol. 159; no. 4; pp. 775 - 788
• Main Authors: Gao, Peng, Postiglione, Maria Pia, Krieger, Teresa G., Hernandez, Luisirene, Wang, Chao, Han, Zhi, Streicher, Carmen, Papusheva, Ekaterina, Insolera, Ryan, Chugh, Kritika, Kodish, Oren, Huang, Kun, Simons, Benjamin D., Luo, Liqun, Hippenmeyer, Simon, Shi, Song-Hai
• Format: Journal Article
• Language: English
• Published: United States Cell Press 06.11.2014
• Subjects: Animals; Mice; morphogenesis; neocortex; Neocortex - cytology; Neurogenesis; Neuroglia - metabolism; neurons; Neurons - metabolism; Otx Transcription Factors - metabolism; quantitative analysis; Staining and Labeling - methods; Stem Cells - metabolism; transcription factors

Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons. To gain insight into the patterns of RGP division and neuron production, we quantitatively analyzed excitatory neuron genesis in the mouse neocortex using Mosaic Analysis with Double Markers, which provides...