The challenge and prospect of mRNA therapeutics landscape

• Published in: Biotechnology advances Vol. 40; pp. 107534 - 23
• Main Authors: Weng, Yuhua, Li, Chunhui, Yang, Tongren, Hu, Bo, Zhang, Mengjie, Guo, Shuai, Xiao, Haihua, Liang, Xing-Jie, Huang, Yuanyu
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2020; Elsevier Science Ltd
• Subjects: biopharmaceuticals; cost effectiveness; Customization; Drug Industry; Gene therapy; Humans; immunogenicity; In vitro transcription; manufacturing; messenger RNA; mRNA delivery; mRNA modification; mRNA therapeutics; Nucleic acid therapeutics; nucleotide sequences; patients; pharmaceutical industry; Pharmaceutical Preparations; Pharmaceuticals; Proteins; recombinant proteins; RNA, Messenger - genetics; therapeutics; transcription (genetics); Vaccines; In vitro transcription; Nucleic acid therapeutics; mRNA therapeutics; mRNA delivery; Gene therapy; mRNA modification

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution in the pharmaceutical industry because they can be used for precise and individualized therapy, and enable patients to produce therapeutic proteins in their own bodies without struggling with the comprehensive man...