Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing

• Published in: Clinical gastroenterology and hepatology Vol. 22; no. 2; pp. 259 - 270
• Main Authors: Leite, Gabriela, Rezaie, Ali, Mathur, Ruchi, Barlow, Gillian M., Rashid, Mohamad, Hosseini, Ava, Wang, Jiajing, Parodi, Gonzalo, Villanueva-Millan, Maria Jesus, Sanchez, Maritza, Morales, Walter, Weitsman, Stacy, Pimentel, Mark, hristopher Almario, M.D., Basseri, Benjamin, Chan, Yin, Chang, Bianca, Cheng, Derek, Enayati, Pedram, Gaddam, Srinivas, Jamil, Laith, Liu, Quin, Lo, Simon, Makhani, Marc, Midani, Deena, Noureddin, Mazen, Park, Kenneth, Paski, Shirley, Pichetshote, Nipaporn, Rabizadeh, Shervin, Ross, Soraya, Shaye, Omid, Watson, Rabindra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2024
• Subjects: Agar; Breath Tests; Escherichia; Escherichia coli; Gastroenterology and Hepatology; Gastrointestinal Diseases; High-Throughput Nucleotide Sequencing; Humans; Hydrogen; Hydrogen Sulfide; Klebsiella; Metabolic Pathways; Small Intestinal Bacterial Overgrowth; Small Intestinal Microbiome; Klebsiella; Escherichia; GI; EGD; Small Intestinal Microbiome; SIBO; F; rRNA; GLM; MAC; RA; OTU; CFU; SparCC; IBS; Metabolic Pathways; DA; FC; Small Intestinal Bacterial Overgrowth; BMI; fold change; esophagogastroduodenoscopy; relative abundance; MacConkey agar; ribosomal RNA; female; irritable bowel syndrome; body mass index; operational taxonomic unit; duodenal aspirate; gastrointestinal; generalized linear model; colony forming unit; sparse correlations for compositional data

Despite accelerated research in small intestinal bacterial overgrowth (SIBO), questions remain regarding optimal diagnostic approaches and definitions. Here, we aim to define SIBO using small bowel culture and sequencing, identifying specific contributory microbes, in the context of gastrointestinal...