Pancreatic cancer stem cell proliferation is strongly inhibited by diethyldithiocarbamate-copper complex loaded into hyaluronic acid decorated liposomes

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 1; pp. 61 - 72
• Main Authors: Marengo, Alessandro, Forciniti, Stefania, Dando, Ilaria, Dalla Pozza, Elisa, Stella, Barbara, Tsapis, Nicolas, Yagoubi, Najet, Fanelli, Giuseppina, Fattal, Elias, Heeschen, Christopher, Palmieri, Marta, Arpicco, Silvia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2019; Elsevier
• Subjects: acetylcysteine; adenocarcinoma; antineoplastic activity; CD44; cell lines; cell proliferation; copper nanoparticles; cryo-electron microscopy; crystals; Diethyldithiocarbamate/copper complex; encapsulation; Galenic pharmacology; Hyaluronic acid; in vitro studies; Life Sciences; Liposomes; mechanism of action; metastasis; nanomedicine; neoplasm cells; neutralization tests; Pancreatic cancer stem cells; pancreatic neoplasms; patients; PDAC patient-derived cells; Pharmaceutical sciences; relapse; stem cells; therapeutics; transmission electron microscopy; Pancreatic cancer stem cells; Liposomes; Diethyldithiocarbamate/copper complex; Hyaluronic acid; CD44; PDAC patient-derived cells

Pancreatic cancer stem cells (CSCs) are responsible for resistance to standard therapy, metastatic potential, and disease relapse following treatments. The current therapy for pancreatic ductal adenocarcinoma (PDAC) preferentially targets the more differentiated cancer cell population, leaving CSCs...