Familial Occurrence of Pulmonary Embolism after Intravenous, Adipose Tissue-Derived Stem Cell Therapy
The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family memb...
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| Published in | Yonsei medical journal Vol. 54; no. 5; pp. 1293 - 1296 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Yonsei University College of Medicine
01.09.2013
연세대학교의과대학 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0513-5796 1976-2437 1976-2437 |
| DOI | 10.3349/ymj.2013.54.5.1293 |
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| Abstract | The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5 μg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients. |
|---|---|
| AbstractList | The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5 μg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients. KCI Citation Count: 46 The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5 μg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients. The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5 μg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients.The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 μg/mL (normal; 0-0.5 μg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients. The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 µg/mL (normal; 0-0.5 µg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients. |
| Author | Choi, Jae Chol Jung, Jae Woo Kwon, Minsuk Choi, Byoung Whui Kim, Jae Yeol Shin, Jong Wook Park, In Won |
| AuthorAffiliation | Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea |
| AuthorAffiliation_xml | – name: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Jae Woo surname: Jung fullname: Jung, Jae Woo organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 2 givenname: Minsuk surname: Kwon fullname: Kwon, Minsuk organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 3 givenname: Jae Chol surname: Choi fullname: Choi, Jae Chol organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 4 givenname: Jong Wook surname: Shin fullname: Shin, Jong Wook organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 5 givenname: In Won surname: Park fullname: Park, In Won organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 6 givenname: Byoung Whui surname: Choi fullname: Choi, Byoung Whui organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea – sequence: 7 givenname: Jae Yeol surname: Kim fullname: Kim, Jae Yeol organization: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23918585$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001794725$$DAccess content in National Research Foundation of Korea (NRF) |
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| SubjectTerms | Adipose Tissue - cytology Adult Case Report Cell- and Tissue-Based Therapy - adverse effects Female Humans Male Mesenchymal Stem Cell Transplantation - adverse effects Pulmonary Embolism - diagnostic imaging Pulmonary Embolism - etiology Pulmonary Infarction - diagnostic imaging Pulmonary Infarction - etiology Tomography, X-Ray Computed 의학일반 |
| Title | Familial Occurrence of Pulmonary Embolism after Intravenous, Adipose Tissue-Derived Stem Cell Therapy |
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