The NIH Somatic Cell Genome Editing program

• Published in: Nature (London) Vol. 592; no. 7853; pp. 195 - 204
• Main Authors: Saha, Krishanu, Sontheimer, Erik J., Brooks, P. J., Dwinell, Melinda R., Gersbach, Charles A., Liu, David R., Murray, Stephen A., Tsai, Shengdar Q., Wilson, Ross C., Anderson, Daniel G., Asokan, Aravind, Banfield, Jillian F., Bankiewicz, Krystof S., Bao, Gang, Bulte, Jeff W. M., Bursac, Nenad, Campbell, Jarryd M., Carlson, Daniel F., Chaikof, Elliot L., Chen, Zheng-Yi, Cheng, R. Holland, Clark, Karl J., Curiel, David T., Dahlman, James E., Deverman, Benjamin E., Dickinson, Mary E., Doudna, Jennifer A., Ekker, Stephen C., Emborg, Marina E., Feng, Guoping, Freedman, Benjamin S., Gamm, David M., Gao, Guangping, Ghiran, Ionita C., Glazer, Peter M., Gong, Shaoqin, Heaney, Jason D., Hennebold, Jon D., Hinson, John T., Khvorova, Anastasia, Kiani, Samira, Lagor, William R., Lam, Kit S., Leong, Kam W., Levine, Jon E., Lewis, Jennifer A., Lutz, Cathleen M., Ly, Danith H., Maragh, Samantha, McCray, Paul B., McDevitt, Todd C., Mirochnitchenko, Oleg, Morizane, Ryuji, Murthy, Niren, Prather, Randall S., Ronald, John A., Roy, Subhojit, Roy, Sushmita, Sabbisetti, Venkata, Saltzman, W. Mark, Santangelo, Philip J., Segal, David J., Shimoyama, Mary, Skala, Melissa C., Tarantal, Alice F., Tilton, John C., Truskey, George A., Vandsburger, Moriel, Watts, Jonathan K., Wells, Kevin D., Wolfe, Scot A., Xu, Qiaobing, Xue, Wen, Yi, Guohua, Zhou, Jiangbing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.04.2021; Nature Publishing Group
• Subjects: 13/100; 13/107; 42/100; 42/44; 45/41; 59/57; 59/78; 631/61/201/2110; 64/60; 692/308/2056; Animal models; Animals; BASIC BIOLOGICAL SCIENCES; Biomedical materials; Cells - metabolism; Consortia; CRISPR; Deoxyribonucleic acid; DNA; Editing; Enzymes; Gene Editing - methods; Gene therapy; Genetic Therapy; Genome editing; Genome, Human - genetics; Genomes; Goals; Humanities and Social Sciences; Humans; In vivo methods and tests; Mitochondrial DNA; multidisciplinary; Mutation; National Institutes of Health (U.S.) - organization & administration; Patients; Perspective; Science; Science (multidisciplinary); Sickle cell disease; Somatic cells; Toolkits; United States; United States; United States > US

The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of diseas...