The NIH Somatic Cell Genome Editing program
The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of diseas...
Saved in:
Published in | Nature (London) Vol. 592; no. 7853; pp. 195 - 204 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
08.04.2021
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium’s plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled—along with validated datasets—into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit—and the knowledge generated by its applications—as a means to accelerate the clinical development of new therapies for a wide range of conditions.
This Perspective discusses how the Somatic Cell Genome Editing Consortium aims to accelerate the implementation of safe and effective genome-editing therapies in the clinic. |
---|---|
AbstractList | Abstract
The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium’s plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled—along with validated datasets—into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit—and the knowledge generated by its applications—as a means to accelerate the clinical development of new therapies for a wide range of conditions. The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium’s plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled—along with validated datasets—into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit—and the knowledge generated by its applications—as a means to accelerate the clinical development of new therapies for a wide range of conditions. The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium's plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled-along with validated datasets-into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit-and the knowledge generated by its applications-as a means to accelerate the clinical development of new therapies for a wide range of conditions.The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium's plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled-along with validated datasets-into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit-and the knowledge generated by its applications-as a means to accelerate the clinical development of new therapies for a wide range of conditions. The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more-effective methods to edit the genomes of disease-relevant somatic cells in patients, even in tissues that are difficult to reach. Here we discuss the consortium’s plans to develop and benchmark approaches to induce and measure genome modifications, and to define downstream functional consequences of genome editing within human cells. Central to this effort is a rigorous and innovative approach that requires validation of the technology through third-party testing in small and large animals. New genome editors, delivery technologies and methods for tracking edited cells in vivo, as well as newly developed animal models and human biological systems, will be assembled—along with validated datasets—into an SCGE Toolkit, which will be disseminated widely to the biomedical research community. We visualize this toolkit—and the knowledge generated by its applications—as a means to accelerate the clinical development of new therapies for a wide range of conditions. This Perspective discusses how the Somatic Cell Genome Editing Consortium aims to accelerate the implementation of safe and effective genome-editing therapies in the clinic. |
Author | Vandsburger, Moriel Santangelo, Philip J. Gersbach, Charles A. Liu, David R. Clark, Karl J. Anderson, Daniel G. Cheng, R. Holland Deverman, Benjamin E. Doudna, Jennifer A. Campbell, Jarryd M. Glazer, Peter M. Xue, Wen Skala, Melissa C. Roy, Subhojit Morizane, Ryuji Tarantal, Alice F. Zhou, Jiangbing Lutz, Cathleen M. Lam, Kit S. Prather, Randall S. Dahlman, James E. Heaney, Jason D. Hennebold, Jon D. Brooks, P. J. Saltzman, W. Mark Wilson, Ross C. Tilton, John C. Sontheimer, Erik J. Feng, Guoping Saha, Krishanu McDevitt, Todd C. Carlson, Daniel F. Segal, David J. Xu, Qiaobing Yi, Guohua Chen, Zheng-Yi Roy, Sushmita Dickinson, Mary E. Chaikof, Elliot L. Dwinell, Melinda R. Ly, Danith H. Levine, Jon E. Mirochnitchenko, Oleg Gong, Shaoqin Shimoyama, Mary Bankiewicz, Krystof S. Truskey, George A. Bao, Gang Gao, Guangping Wells, Kevin D. Curiel, David T. Hinson, John T. Leong, Kam W. McCray, Paul B. Sabbisetti, Venkata Ronald, John A. Freedman, Benjamin S. Kiani, Samira Ekker, Stephen C. Bursac, Nenad Gamm, David M. Murthy, Niren Tsai, Shengdar Q. Lewi |
Author_xml | – sequence: 1 givenname: Krishanu orcidid: 0000-0003-2837-0858 surname: Saha fullname: Saha, Krishanu email: ksaha@wisc.edu organization: Department of Biomedical Engineering, University of Wisconsin-Madison, Department of Medical History & Bioethics, University of Wisconsin-Madison, Wisconsin Institute for Discovery, University of Wisconsin-Madison, McPherson Eye Research Institute, University of Wisconsin-Madison – sequence: 2 givenname: Erik J. orcidid: 0000-0002-0881-0310 surname: Sontheimer fullname: Sontheimer, Erik J. email: erik.sontheimer@umassmed.edu organization: RNA Therapeutics Institute, University of Massachusetts Medical School – sequence: 3 givenname: P. J. surname: Brooks fullname: Brooks, P. J. organization: Office of Rare Diseases Research, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health – sequence: 4 givenname: Melinda R. surname: Dwinell fullname: Dwinell, Melinda R. organization: Department of Physiology, Medical College of Wisconsin – sequence: 5 givenname: Charles A. orcidid: 0000-0003-1478-4013 surname: Gersbach fullname: Gersbach, Charles A. organization: Department of Biomedical Engineering, Duke University – sequence: 6 givenname: David R. orcidid: 0000-0002-9943-7557 surname: Liu fullname: Liu, David R. organization: Merkin Institute of Transformative Technologies, Broad Institute of MIT and Harvard, Department of Chemistry and Chemical Biology, Harvard University, Howard Hughes Medical Institute – sequence: 7 givenname: Stephen A. surname: Murray fullname: Murray, Stephen A. organization: The Jackson Laboratory – sequence: 8 givenname: Shengdar Q. orcidid: 0000-0001-9161-3993 surname: Tsai fullname: Tsai, Shengdar Q. organization: Department of Hematology, St Jude Children’s Research Hospital – sequence: 9 givenname: Ross C. orcidid: 0000-0002-0644-5540 surname: Wilson fullname: Wilson, Ross C. organization: Innovative Genomics Institute, University of California, Berkeley – sequence: 10 givenname: Daniel G. orcidid: 0000-0001-5629-4798 surname: Anderson fullname: Anderson, Daniel G. organization: Department of Chemical Engineering, Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology – sequence: 11 givenname: Aravind orcidid: 0000-0001-5563-4877 surname: Asokan fullname: Asokan, Aravind organization: Department of Biomedical Engineering, Duke University, Department of Surgery, Duke University School of Medicine – sequence: 12 givenname: Jillian F. orcidid: 0000-0001-8203-8771 surname: Banfield fullname: Banfield, Jillian F. organization: Innovative Genomics Institute, University of California, Berkeley, Department of Earth and Planetary Sciences, University of California, Berkeley – sequence: 13 givenname: Krystof S. surname: Bankiewicz fullname: Bankiewicz, Krystof S. organization: Department of Neurological Surgery, Ohio State University – sequence: 14 givenname: Gang surname: Bao fullname: Bao, Gang organization: Department of Bioengineering, Rice University – sequence: 15 givenname: Jeff W. M. surname: Bulte fullname: Bulte, Jeff W. M. organization: Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine – sequence: 16 givenname: Nenad surname: Bursac fullname: Bursac, Nenad organization: Department of Biomedical Engineering, Duke University – sequence: 17 givenname: Jarryd M. surname: Campbell fullname: Campbell, Jarryd M. organization: Recombinetics, Inc – sequence: 18 givenname: Daniel F. orcidid: 0000-0001-6095-2108 surname: Carlson fullname: Carlson, Daniel F. organization: Recombinetics, Inc – sequence: 19 givenname: Elliot L. orcidid: 0000-0001-6184-4571 surname: Chaikof fullname: Chaikof, Elliot L. organization: Department of Surgery, Beth Israel Deaconess Medical Center – sequence: 20 givenname: Zheng-Yi orcidid: 0000-0002-1452-4193 surname: Chen fullname: Chen, Zheng-Yi organization: Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Program in Neuroscience, Harvard Medical School, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary – sequence: 21 givenname: R. Holland surname: Cheng fullname: Cheng, R. Holland organization: Department of Molecular and Cellular Biology, University of California, Davis – sequence: 22 givenname: Karl J. orcidid: 0000-0002-9637-0967 surname: Clark fullname: Clark, Karl J. organization: Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester – sequence: 23 givenname: David T. surname: Curiel fullname: Curiel, David T. organization: Department of Radiation Oncology, Washington University in St Louis – sequence: 24 givenname: James E. surname: Dahlman fullname: Dahlman, James E. organization: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology – sequence: 25 givenname: Benjamin E. surname: Deverman fullname: Deverman, Benjamin E. organization: Stanley Center for Psychiatric Research, Broad Institute – sequence: 26 givenname: Mary E. surname: Dickinson fullname: Dickinson, Mary E. organization: Department of Molecular Physiology and Biophysics, Baylor College of Medicine – sequence: 27 givenname: Jennifer A. surname: Doudna fullname: Doudna, Jennifer A. organization: Innovative Genomics Institute, University of California, Berkeley, Department of Chemistry, University of California, Berkeley, Department of Molecular and Cell Biology, University of California, Berkeley, California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Howard Hughes Medical Institute, University of California, Berkeley, Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes – sequence: 28 givenname: Stephen C. orcidid: 0000-0003-0726-4212 surname: Ekker fullname: Ekker, Stephen C. organization: Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester – sequence: 29 givenname: Marina E. orcidid: 0000-0002-9351-6641 surname: Emborg fullname: Emborg, Marina E. organization: Department of Medical Physics, University of Wisconsin-Madison, Wisconsin National Primate Research Center, University of Wisconsin-Madison – sequence: 30 givenname: Guoping orcidid: 0000-0002-8021-277X surname: Feng fullname: Feng, Guoping organization: McGovern Institute for Brain Research, Massachusetts Institute of Technology – sequence: 31 givenname: Benjamin S. surname: Freedman fullname: Freedman, Benjamin S. organization: Division of Nephrology, University of Washington, Kidney Research Institute, University of Washington, Institute for Stem Cell and Regenerative Medicine, University of Washington, Department of Medicine, University of Washington – sequence: 32 givenname: David M. orcidid: 0000-0002-8152-613X surname: Gamm fullname: Gamm, David M. organization: McPherson Eye Research Institute, University of Wisconsin-Madison, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison – sequence: 33 givenname: Guangping orcidid: 0000-0003-0097-9012 surname: Gao fullname: Gao, Guangping organization: Horae Gene Therapy Center, University of Massachusetts Medical School – sequence: 34 givenname: Ionita C. surname: Ghiran fullname: Ghiran, Ionita C. organization: Department of Medicine, Beth Israel Deaconess Medical Center – sequence: 35 givenname: Peter M. orcidid: 0000-0003-4525-5560 surname: Glazer fullname: Glazer, Peter M. organization: Department of Therapeutic Radiology, Yale University – sequence: 36 givenname: Shaoqin surname: Gong fullname: Gong, Shaoqin organization: Department of Biomedical Engineering, University of Wisconsin-Madison, Wisconsin Institute for Discovery, University of Wisconsin-Madison, McPherson Eye Research Institute, University of Wisconsin-Madison – sequence: 37 givenname: Jason D. orcidid: 0000-0001-8475-8828 surname: Heaney fullname: Heaney, Jason D. organization: Department of Molecular and Human Genetics, Baylor College of Medicine – sequence: 38 givenname: Jon D. surname: Hennebold fullname: Hennebold, Jon D. organization: Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University – sequence: 39 givenname: John T. surname: Hinson fullname: Hinson, John T. organization: Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine – sequence: 40 givenname: Anastasia orcidid: 0000-0001-6928-8071 surname: Khvorova fullname: Khvorova, Anastasia organization: RNA Therapeutics Institute, University of Massachusetts Medical School – sequence: 41 givenname: Samira surname: Kiani fullname: Kiani, Samira organization: Pittsburgh Liver Research Center, Department of Pathology, University of Pittsburgh School of Medicine – sequence: 42 givenname: William R. surname: Lagor fullname: Lagor, William R. organization: Department of Molecular Physiology and Biophysics, Baylor College of Medicine – sequence: 43 givenname: Kit S. surname: Lam fullname: Lam, Kit S. organization: Department of Biochemistry and Molecular Medicine, University of California, Davis – sequence: 44 givenname: Kam W. orcidid: 0000-0002-8133-4955 surname: Leong fullname: Leong, Kam W. organization: Department of Biomedical Engineering, Columbia University – sequence: 45 givenname: Jon E. surname: Levine fullname: Levine, Jon E. organization: Wisconsin National Primate Research Center, University of Wisconsin-Madison – sequence: 46 givenname: Jennifer A. orcidid: 0000-0002-0280-2774 surname: Lewis fullname: Lewis, Jennifer A. organization: Wyss Institute, Harvard University – sequence: 47 givenname: Cathleen M. surname: Lutz fullname: Lutz, Cathleen M. organization: The Jackson Laboratory – sequence: 48 givenname: Danith H. surname: Ly fullname: Ly, Danith H. organization: Department of Chemistry, Carnegie-Mellon University – sequence: 49 givenname: Samantha surname: Maragh fullname: Maragh, Samantha organization: Biomarker and Genomic Sciences Group, National Institute of Standards and Technology – sequence: 50 givenname: Paul B. orcidid: 0000-0002-4067-577X surname: McCray fullname: McCray, Paul B. organization: Department of Pediatrics, University of Iowa – sequence: 51 givenname: Todd C. orcidid: 0000-0002-8905-4931 surname: McDevitt fullname: McDevitt, Todd C. organization: Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco – sequence: 52 givenname: Oleg surname: Mirochnitchenko fullname: Mirochnitchenko, Oleg organization: Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health – sequence: 53 givenname: Ryuji surname: Morizane fullname: Morizane, Ryuji organization: Department of Medicine, Massachusetts General Hospital, Harvard Medical School – sequence: 54 givenname: Niren surname: Murthy fullname: Murthy, Niren organization: Innovative Genomics Institute, University of California, Berkeley, Department of Bioengineering, University of California, Berkeley – sequence: 55 givenname: Randall S. orcidid: 0000-0002-6012-4035 surname: Prather fullname: Prather, Randall S. organization: Division of Animal Sciences, University of Missouri – sequence: 56 givenname: John A. surname: Ronald fullname: Ronald, John A. organization: Robarts Research Institute and Department of Medical Biophysics, The University of Western Ontario, London – sequence: 57 givenname: Subhojit surname: Roy fullname: Roy, Subhojit organization: Department of Pathology, University of California, San Diego – sequence: 58 givenname: Sushmita surname: Roy fullname: Roy, Sushmita organization: Department of Biomedical Engineering, University of Wisconsin-Madison, Wisconsin Institute for Discovery, University of Wisconsin-Madison, McPherson Eye Research Institute, University of Wisconsin-Madison, Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison – sequence: 59 givenname: Venkata orcidid: 0000-0001-8696-2726 surname: Sabbisetti fullname: Sabbisetti, Venkata organization: Department of Medicine, Brigham and Women’s Hospital – sequence: 60 givenname: W. Mark orcidid: 0000-0002-2163-549X surname: Saltzman fullname: Saltzman, W. Mark organization: Department of Biomedical Engineering, Yale University – sequence: 61 givenname: Philip J. orcidid: 0000-0001-7352-0339 surname: Santangelo fullname: Santangelo, Philip J. organization: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology – sequence: 62 givenname: David J. orcidid: 0000-0001-8962-3105 surname: Segal fullname: Segal, David J. organization: Department of Biochemistry and Molecular Medicine, University of California, Davis – sequence: 63 givenname: Mary surname: Shimoyama fullname: Shimoyama, Mary organization: Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin – sequence: 64 givenname: Melissa C. orcidid: 0000-0002-6320-7637 surname: Skala fullname: Skala, Melissa C. organization: Department of Biomedical Engineering, University of Wisconsin-Madison, McPherson Eye Research Institute, University of Wisconsin-Madison, Morgridge Institute for Research – sequence: 65 givenname: Alice F. surname: Tarantal fullname: Tarantal, Alice F. organization: Department of Pediatrics, University of California, Davis, Department of Cell Biology and Human Anatomy, University of California, Davis, School of Medicine, University of California, Davis, California National Primate Research Center, University of California, Davis – sequence: 66 givenname: John C. surname: Tilton fullname: Tilton, John C. organization: Department of Nutrition, Case Western Reserve University – sequence: 67 givenname: George A. surname: Truskey fullname: Truskey, George A. organization: Department of Biomedical Engineering, Duke University – sequence: 68 givenname: Moriel surname: Vandsburger fullname: Vandsburger, Moriel organization: Department of Bioengineering, University of California, Berkeley – sequence: 69 givenname: Jonathan K. surname: Watts fullname: Watts, Jonathan K. organization: RNA Therapeutics Institute, University of Massachusetts Medical School – sequence: 70 givenname: Kevin D. surname: Wells fullname: Wells, Kevin D. organization: Division of Animal Sciences, University of Missouri – sequence: 71 givenname: Scot A. orcidid: 0000-0002-7042-201X surname: Wolfe fullname: Wolfe, Scot A. organization: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester – sequence: 72 givenname: Qiaobing surname: Xu fullname: Xu, Qiaobing organization: Department of Biomedical Engineering, Tufts University – sequence: 73 givenname: Wen surname: Xue fullname: Xue, Wen organization: RNA Therapeutics Institute, University of Massachusetts Medical School – sequence: 74 givenname: Guohua surname: Yi fullname: Yi, Guohua organization: Department of Pulmonary Immunology, University of Texas Health Sciences Center at Tyler – sequence: 75 givenname: Jiangbing orcidid: 0000-0002-1201-5360 surname: Zhou fullname: Zhou, Jiangbing organization: Department of Neurosurgery, Yale University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33828315$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1815941$$D View this record in Osti.gov |
BookMark | eNp9kU9PGzEQxa2KqgToF-ihWrUXpGrBY6__7AUJRRSQEByAs-U4s4lR1k7tDVK_PU6XAu2Bkw_v5_dm5u2RnRADEvIF6BFQro9zA0LLmjKoKYcWavhAJtAoWTdSqx0yoZTpmmoud8lezg-UUgGq-UR2OddMcxAT8uNuidX15UV1G3s7eFdNcbWqzjHEHquzuR98WFTrFBfJ9gfkY2dXGT8_v_vk_ufZ3fSivro5v5yeXtVOUBjqpuNSAXe6tZIr5WZs5uRccAECEWTJppa3FLoizOzcOtSdtoxZ1wI4xfk-ORl915tZj3OHYUh2ZdbJ9zb9NtF6868S_NIs4qPRlEneqmLwbTSIefAmOz-gW7oYArrBgAbRNlCgw-eUFH9tMA-m99mV7W3AuMmGCaBMNLzVBf3-H_oQNymUG2wp4FoJuh2bjZRLMeeE3cvEQM22MDMWZkph5k9hZjvF17e7vnz521AB-AjkIoUFptfsd2yfAFBpoAU |
CitedBy_id | crossref_primary_10_1002_hep_32441 crossref_primary_10_1007_s00439_024_02651_8 crossref_primary_10_1016_j_biopha_2022_114189 crossref_primary_10_1016_j_fertnstert_2023_02_040 crossref_primary_10_1021_acsnano_2c00909 crossref_primary_10_1038_s42003_023_04974_0 crossref_primary_10_1016_j_ymthe_2023_06_019 crossref_primary_10_1016_j_ymthe_2021_06_014 crossref_primary_10_1038_s41568_022_00491_0 crossref_primary_10_1016_j_biomaterials_2021_121233 crossref_primary_10_1172_JCI177383 crossref_primary_10_1016_j_biomaterials_2022_121959 crossref_primary_10_3389_fphar_2022_1077352 crossref_primary_10_1038_s41467_023_43904_w crossref_primary_10_1038_s43587_022_00326_5 crossref_primary_10_3389_fgene_2021_750142 crossref_primary_10_1016_j_cell_2022_03_045 crossref_primary_10_1186_s13148_022_01303_w crossref_primary_10_1186_s12967_021_02864_9 crossref_primary_10_1002_smtd_202300069 crossref_primary_10_1016_j_ppedcard_2021_101460 crossref_primary_10_1016_j_ymthe_2021_10_019 crossref_primary_10_1038_s41467_022_31927_8 crossref_primary_10_1038_s41571_022_00717_y crossref_primary_10_1021_acs_biochem_2c00379 crossref_primary_10_1089_crispr_2022_29148_lal crossref_primary_10_1089_hum_2024_035 crossref_primary_10_1177_00236772211051842 crossref_primary_10_1038_s42003_022_03813_y crossref_primary_10_1146_annurev_animal_021419_083813 crossref_primary_10_1126_scitranslmed_abm5527 crossref_primary_10_3389_fbioe_2023_1237613 crossref_primary_10_1089_genbio_2023_29094_cma crossref_primary_10_1016_j_xjtc_2022_01_012 crossref_primary_10_1093_nar_gkac887 crossref_primary_10_1002_ar_24849 crossref_primary_10_1016_j_ymthe_2021_10_023 crossref_primary_10_3724_abbs_2022056 crossref_primary_10_3389_fnmol_2022_905328 crossref_primary_10_1089_crispr_2022_0045 crossref_primary_10_1016_j_jconrel_2022_04_049 crossref_primary_10_1016_j_jconrel_2023_04_009 crossref_primary_10_1038_s41467_022_28771_1 crossref_primary_10_1038_s41576_024_00709_x crossref_primary_10_1038_s41588_022_01272_z crossref_primary_10_1126_sciadv_abo0522 crossref_primary_10_3390_biologics3040014 crossref_primary_10_1089_crispr_2023_0048 crossref_primary_10_1146_annurev_genom_083117_021702 crossref_primary_10_3390_ph16060855 crossref_primary_10_1016_j_atherosclerosis_2023_01_010 crossref_primary_10_1016_j_xpro_2021_101088 crossref_primary_10_1073_pnas_2302910120 crossref_primary_10_1515_mr_2021_0010 crossref_primary_10_3389_fnbeh_2022_1006065 crossref_primary_10_3389_fgeed_2022_974798 crossref_primary_10_1017_S0140525X22002138 crossref_primary_10_1364_BOE_455783 crossref_primary_10_1002_ajmg_c_32031 crossref_primary_10_1360_SSV_2021_0118 crossref_primary_10_1016_j_ymthe_2024_03_028 crossref_primary_10_3390_ijms24065798 crossref_primary_10_3389_fgeed_2021_737632 crossref_primary_10_1007_s00109_021_02086_y crossref_primary_10_1038_s41467_021_24707_3 crossref_primary_10_1016_j_tins_2023_02_005 |
Cites_doi | 10.1038/s41586-020-1978-5 10.1126/science.aau1549 10.1016/j.addr.2018.12.007 10.1056/NEJMoa1817426 10.1038/s41591-020-0790-y 10.1126/science.abb1400 10.1038/s41551-019-0431-2 10.1089/hum.2015.087 10.1126/science.aad5143 10.1038/s41591-018-0326-x 10.1038/nbt.4182 10.1038/s41467-019-09693-x 10.1016/j.biomaterials.2019.119416 10.1038/s41598-018-22993-4 10.1038/s41591-019-0478-3 10.1073/pnas.1208507109 10.1038/nbt.2507 10.1038/s41556-018-0202-4 10.1038/s41591-019-0344-3 10.1038/s41587-020-0609-x 10.1073/pnas.91.13.6064 10.1126/science.1232033 10.7554/eLife.00471 10.1038/nbt.4148 10.1038/s41586-019-1711-4 10.1126/science.aba7365 10.18383/j.tom.2015.00172 10.1038/nature10177 10.1038/nbt.2501 10.1016/j.molcel.2020.02.023 10.1016/j.cell.2020.03.023 10.1126/science.aav7271 10.1126/science.aav9023 10.1038/s41591-018-0204-6 10.1038/ncomms7952 10.1016/j.celrep.2018.02.014 10.1038/nbt.3806 10.1016/j.omtm.2018.06.006 10.1371/journal.pbio.1002165 10.1016/j.cell.2016.11.007 10.1038/nature03556 10.1038/mt.2016.10 10.1038/nbt.3117 10.1038/s41586-019-0908-x 10.1038/nmeth.3076 10.1126/scitranslmed.aay9101 10.1126/sciadv.aau0766 10.1101/gr.255414.119 10.1126/science.aah6192 10.1039/C8LC00553B 10.1126/scitranslmed.aan8081 10.1146/annurev-biochem-013118-111730 10.1016/j.tig.2017.11.001 10.1126/science.1231143 10.1038/nature17946 10.3390/molecules25030735 10.1371/journal.pbio.2004299 10.1038/nature23884 10.1056/NEJMra1706910 10.1101/287342 10.1056/NEJMoa1300662 10.1038/nbt.3471 10.1089/hum.2006.17.1254 10.1038/s41591-019-0738-2 10.1038/s41587-020-0555-7 10.1038/s41551-019-0357-8 10.1038/nmeth.2408 10.1038/s41587-020-0527-y 10.1016/j.jconrel.2016.01.005 10.1038/s41591-018-0209-1 10.1038/s41587-020-0592-2 10.1073/pnas.1313587110 10.1016/j.ymthe.2018.08.007 10.1038/s41596-018-0055-0 10.1126/scitranslmed.aaj2013 10.3390/genes11050511 10.1038/nmeth.3325 10.1038/s41587-020-0565-5 10.1038/nmeth.4278 10.1016/j.molcel.2018.12.003 10.1038/nature15521 10.1038/s41587-020-0535-y 10.1038/nbt.3765 10.1177/0300985817738095 10.1126/science.1225829 10.1016/j.cell.2016.01.039 10.1038/nature24644 10.1126/science.aad5177 10.1038/s41467-017-01408-4 10.1126/science.8211127 10.1038/nbt.1948 10.1016/j.cell.2015.09.038 10.1038/nbt.3199 10.1038/nrd.2016.280 10.1056/NEJMra1800729 10.1038/nbt.4194 10.1146/annurev-genom-083117-021632 10.1038/s41576-018-0059-1 10.1038/s41587-020-0509-0 10.1016/j.tibtech.2019.01.009 10.2310/7290.2008.00001 10.1038/s41556-019-0425-z 10.2174/156652312799789235 10.1038/nature21059 10.1038/nmeth.3993 10.1038/nrd.2018.91 10.1038/s41565-019-0539-2 10.1038/s41579-019-0299-x 10.1093/nar/gkl720 10.1038/nbt.2508 10.1038/nmeth.3284 10.1089/hum.2009.126 10.1038/nmeth.1648 10.1038/s41587-020-0561-9 10.1038/s41591-018-0165-9 10.1038/s41467-019-12922-y 10.1146/annurev-genom-090413-025448 10.1038/nprot.2009.245 10.1038/s41591-018-0166-8 10.1038/nbt.4005 10.1371/journal.pone.0077148 10.1038/s41586-019-1323-z 10.1073/pnas.1614775114 10.1126/science.1105136 10.1016/j.stem.2017.03.021 10.1016/j.ymthe.2020.04.017 10.1126/science.aax9181 10.1038/s41586-020-2477-4 10.1038/s41551-019-0501-5 10.1038/ncomms13304 10.1126/sciadv.aaw5096 10.1038/nrm.2015.2 10.1148/radiol.2016152766 10.1016/j.molcel.2019.03.014 10.1097/RLI.0000000000000542 10.1038/nbt.3198 10.1038/mt.2015.126 10.1038/s41580-019-0131-5 10.1038/nbt.1755 10.1038/s41591-018-0327-9 10.1371/journal.pbio.3000686 10.1016/j.gde.2018.05.001 10.1089/hum.2016.130 10.1038/s41586-019-1629-x 10.1126/science.aaq1067 10.1007/s11307-011-0487-1 10.1038/nmeth.2681 10.1038/nature14299 10.1038/nmeth.4284 |
ContentType | Journal Article |
Copyright | The Author(s) 2021 Copyright Nature Publishing Group Apr 8, 2021 |
Copyright_xml | – notice: The Author(s) 2021 – notice: Copyright Nature Publishing Group Apr 8, 2021 |
CorporateAuthor | SCGE Consortium The SCGE Consortium Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) |
CorporateAuthor_xml | – name: SCGE Consortium – name: The SCGE Consortium – name: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) |
DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PQEST PQQKQ PQUKI PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 OIOZB OTOTI 5PM |
DOI | 10.1038/s41586-021-03191-1 |
DatabaseName | Springer Nature OA Free Journals Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic OSTI.GOV - Hybrid OSTI.GOV PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic University of Michigan Technology Collection Technology Research Database SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | CrossRef Agricultural Science Database MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Sciences (General) Physics |
EISSN | 1476-4687 |
EndPage | 204 |
ExternalDocumentID | 1815941 10_1038_s41586_021_03191_1 33828315 |
Genre | Research Support, Non-U.S. Gov't Journal Article Review |
GeographicLocations | United States United States--US |
GeographicLocations_xml | – name: United States – name: United States--US |
GrantInformation_xml | – fundername: NIBIB NIH HHS grantid: UH3 EB028910 – fundername: NIBIB NIH HHS grantid: UH2 EB028910 – fundername: NIH HHS grantid: U42 OD026645 – fundername: NHLBI NIH HHS grantid: U01 HL145792 – fundername: NIAID NIH HHS grantid: UG3 AI150551 – fundername: NIH HHS grantid: U42 OD026635 – fundername: NIGMS NIH HHS grantid: R35 GM119644 – fundername: NINDS NIH HHS grantid: UH3 NS111688 – fundername: NHLBI NIH HHS grantid: UH3 HL147352 – fundername: NIH HHS grantid: U42 OD027094 |
GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .XZ 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z AAEEF AAHBH AAHTB AAIKC AAKAB AAMNW AASDW AAYEP AAZLF ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABVXF ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH AENEX AFBBN AFFNX AFKRA AFLOW AFRAH AFRQD AFSHS AGAYW AGEZK AGHSJ AGHTU AGSOS AHMBA AHSBF AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARAPS ARMCB ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B-7 BBNVY BCU BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BPHCQ BVXVI C6C CCPQU CJ0 CS3 D1I D1J D1K DU5 DWQXO E.- E.L EAP EBS EE. EMH EPS EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEPJS O9- OBC OES OHH OMK OVD P2P P62 PATMY PCBAR PDBOC PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT TAE TAOOD TBHMF TDRGL TEORI TN5 TSG TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YNT YOC YQT YR2 YXB YZZ ZCA ~02 ~7V ~88 ~KM .-4 .GJ .HR 00M 08P 0B8 1CY 1VW 354 3EH 3O- 3V. 4.4 41~ 42X 4R4 663 79B 9M8 A8Z AAJYS AAKAS AAVBQ AAYOK AAYZH ABAWZ ABDBF ABEFU ABTAH ACBNA ACBTR ACTDY ADRHT ADYSU ADZCM AFFDN AFHKK AGCDD AGNAY AIDAL AIYXT AJUXI APEBS ARTTT B0M BCR BDKGC BES BKOMP BLC CGR CUY CVF DB5 DO4 EAD EAS EAZ EBC EBD EBO ECC ECM EIF EJD EMB EMF EMK EMOBN EPL ESE ESN ESTFP ESX F20 FA8 FAC G8K I-F J5H L-9 LGEZI LOTEE M0L MVM N4W NADUK NEJ NPM NXXTH ODYON OHT P-O PEA PM3 PV9 QS- R4F RHI SKT SV3 TH9 TUD TUS UAO UBY UHB USG VOH X7L XOL YJ6 YQI YQJ YV5 YXA YYP YYQ ZCG ZE2 ZGI ZHY ZKB ZKG ZY4 ~8M ~G0 AAYXX CITATION 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PQEST PQUKI Q9U RC3 SOI 7X8 69O 6XO AADEA AADWK AAEXX AAJMP AAPBV AAYJO ABEEJ ABGFU ABGIJ ABPTK ACBMV ACBRV ACBYP ACIGE ACTTH ACVWB ADFPY ADMDM ADQMX ADZGE AEDAW AEFTE AGGBP AHGBK AJDOV AMRJV I-U OIOZB OTOTI U1R XFK ZA5 5PM |
ID | FETCH-LOGICAL-c501t-4f36713c89a6377cb2bc6d53515ee163380a3901fb2bbadace8f8a22ac911c733 |
IEDL.DBID | C6C |
ISSN | 0028-0836 1476-4687 |
IngestDate | Tue Sep 17 21:27:55 EDT 2024 Thu May 18 22:32:49 EDT 2023 Wed Oct 23 16:43:29 EDT 2024 Thu Oct 10 20:49:13 EDT 2024 Thu Sep 12 17:11:46 EDT 2024 Wed Oct 16 00:41:29 EDT 2024 Fri Oct 11 20:36:42 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7853 |
Language | English |
License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c501t-4f36713c89a6377cb2bc6d53515ee163380a3901fb2bbadace8f8a22ac911c733 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 AC02-05CH11231 USDOE Office of Science (SC) |
ORCID | 0000-0002-8021-277X 0000-0003-0726-4212 0000-0001-9161-3993 0000-0001-7352-0339 0000-0002-9351-6641 0000-0002-8152-613X 0000-0002-1452-4193 0000-0001-6928-8071 0000-0001-5629-4798 0000-0002-8905-4931 0000-0002-7042-201X 0000-0002-6012-4035 0000-0002-0644-5540 0000-0001-8203-8771 0000-0002-9943-7557 0000-0002-1201-5360 0000-0001-5563-4877 0000-0003-2837-0858 0000-0001-6184-4571 0000-0001-8696-2726 0000-0003-0097-9012 0000-0002-0881-0310 0000-0002-4067-577X 0000-0003-1478-4013 0000-0002-8133-4955 0000-0002-9637-0967 0000-0001-8962-3105 0000-0002-0280-2774 0000-0002-6320-7637 0000-0002-2163-549X 0000-0001-8475-8828 0000-0001-6095-2108 0000-0003-4525-5560 000000024067577X 0000000328370858 0000000161844571 0000000173520339 000000027042201X 0000000160952108 0000000212015360 0000000300979012 0000000299437557 0000000184758828 0000000169288071 0000000182038771 0000000293516641 0000000307264212 0000000208810310 0000000214524193 0000000345255560 0000000155634877 0000000296370967 0000000202802774 0000000289054931 0000000260124035 0000000156294798 0000000191613993 0000000186962726 0000000189623105 0000000263207637 000000022163549X 0000000206445540 000000028152613X 0000000314784013 000000028021277X 0000000281334955 |
OpenAccessLink | https://doi.org/10.1038/s41586-021-03191-1 |
PMID | 33828315 |
PQID | 2511387503 |
PQPubID | 40569 |
PageCount | 10 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8026397 osti_scitechconnect_1815941 proquest_miscellaneous_2510254398 proquest_journals_2511387503 crossref_primary_10_1038_s41586_021_03191_1 pubmed_primary_33828315 springer_journals_10_1038_s41586_021_03191_1 |
PublicationCentury | 2000 |
PublicationDate | 2021-04-08 |
PublicationDateYYYYMMDD | 2021-04-08 |
PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-08 day: 08 |
PublicationDecade | 2020 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England – name: United States |
PublicationSubtitle | International weekly journal of science |
PublicationTitle | Nature (London) |
PublicationTitleAbbrev | Nature |
PublicationTitleAlternate | Nature |
PublicationYear | 2021 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Chu (CR117) 2015; 33 van Haasteren, Li, Scheideler, Murthy, Schaffer (CR107) 2020; 38 Wang (CR41) 2018; 36 Jiang, Bikard, Cox, Zhang, Marraffini (CR15) 2013; 31 Holtzman, Gersbach (CR93) 2018; 19 Staahl (CR113) 2017; 35 Komor, Kim, Packer, Zuris, Liu (CR22) 2016; 533 Khvorova, Watts (CR66) 2017; 35 Zhang (CR90) 2020; 38 Wagner (CR45) 2019; 25 Villiger (CR54) 2018; 24 Mali (CR10) 2013; 339 Zeitler (CR94) 2019; 25 Perry, Valdes, Wilder, Austin, Brooks (CR67) 2018; 17 Yeh (CR60) 2020; 12 Naldini, Trono, Verma (CR19) 2016; 353 Bahal (CR98) 2016; 7 Zafra (CR53) 2018; 36 Hu (CR79) 2020; 18 Canver (CR48) 2015; 527 Li (CR55) 2018; 20 Kim (CR135) 2015; 12 Gaudelli (CR23) 2017; 551 Certo (CR118) 2011; 8 Warren, Jaquish, Cowan (CR153) 2017; 20 Liu (CR52) 2018; 9 Freedman, Cockburn, Simcoe (CR146) 2015; 13 Plant (CR148) 2018; 16 Mok (CR24) 2020; 583 Makarova (CR16) 2020; 18 Moreno (CR43) 2019; 3 Bacman (CR102) 2018; 24 Rouet, Smih, Jasin (CR17) 1994; 91 Tabebordbar (CR50) 2016; 351 Tsai (CR134) 2015; 33 McNeer (CR97) 2015; 6 (CR149) 2004; 306 Wu (CR116) 2017; 114 Ran (CR71) 2015; 520 Nelson (CR40) 2019; 25 Chen (CR112) 2019; 14 Cho, Kim, Kim, Kim (CR12) 2013; 31 Wienert (CR139) 2019; 364 Kim (CR72) 2017; 8 Harrington (CR76) 2017; 8 Yin (CR114) 2016; 34 Tarantal, Lee, Martinez, Asokan, Samulski (CR127) 2017; 28 Anzalone, Koblan, Liu (CR4) 2020; 38 Iwano (CR119) 2018; 359 Truskey (CR144) 2018; 18 Tarantal, Lee, Jimenez, Cherry (CR129) 2006; 17 (CR154) 2019; 574 Ryu (CR58) 2018; 36 Hashimoto (CR103) 2015; 23 Nelson (CR49) 2016; 351 Cameron (CR137) 2017; 14 Schmid-Burgk (CR140) 2020; 78 Porteus (CR29) 2019; 380 Anzalone (CR25) 2019; 576 Gasiunas, Barrangou, Horvath, Siksnys (CR9) 2012; 109 Minn (CR121) 2019; 5 Li (CR30) 2011; 475 Nyström (CR132) 2019; 54 Burstein (CR80) 2017; 542 Wei, Cheng, Min, Olson, Siegwart (CR109) 2020; 11 Economos (CR96) 2020; 25 Esvelt (CR68) 2013; 10 Jinek (CR8) 2012; 337 Chew (CR38) 2016; 13 Tarantal (CR125) 2012; 14 Amoasii (CR31) 2018; 362 Minczuk, Kolasinska-Zwierz, Murphy, Papworth (CR100) 2010; 5 Plant, Locascio, May, Gallagher (CR147) 2014; 11 Tarantal, Lee, Kukis, Cherry (CR126) 2013; 8 Crosetto (CR133) 2013; 10 Tsai (CR136) 2017; 14 Wang (CR145) 2019; 221 Urnov (CR5) 2005; 435 Dominguez, Lim, Qi (CR20) 2016; 17 Qasim (CR37) 2017; 9 Krishnamurthy (CR111) 2019; 10 Rees, Liu (CR21) 2018; 19 Sürün (CR63) 2020; 11 Stadtmauer (CR36) 2020; 367 Lazzarotto (CR143) 2020; 38 Charlesworth (CR44) 2019; 25 Gammage, Moraes, Minczuk (CR99) 2018; 34 Chatterjee, Jakimo, Jacobson (CR77) 2018; 4 Gabriel (CR65) 2011; 29 Lazzarotto (CR138) 2018; 13 Tebas (CR34) 2014; 370 Yin (CR110) 2017; 35 Hirano (CR75) 2016; 164 Finn (CR108) 2018; 22 Liu (CR83) 2019; 566 Levy (CR59) 2020; 4 Maeder (CR32) 2019; 25 Zhao (CR92) 2021; 39 Jinek (CR14) 2013; 2 Dekker (CR152) 2017; 549 Zetsche (CR70) 2015; 163 Penheiter, Russell, Carlson (CR120) 2012; 12 Gammage (CR101) 2018; 24 Tarantal, Lee (CR130) 2010; 21 Pausch (CR87) 2020; 369 Pumphrey (CR123) 2017; 282 Kearns (CR26) 2015; 12 Klompe, Vo, Halpin-Healy, Sternberg (CR86) 2019; 571 Black, Gersbach (CR95) 2018; 52 Ferdosi (CR46) 2019; 10 Doudna (CR2) 2020; 578 Agudelo (CR73) 2020; 30 Wang (CR39) 2015; 26 Miller (CR7) 2011; 29 Maeder, Gersbach (CR28) 2016; 24 Huang, Lee, Sutcliffe, Cherry, Tarantal (CR124) 2008; 7 Smith (CR6) 2006; 34 Hwang (CR13) 2013; 31 Xu (CR35) 2019; 381 Brown, Celniker (CR150) 2015; 16 Pickar-Oliver, Gersbach (CR3) 2019; 20 Sakata (CR88) 2020; 38 Simhadri (CR142) 2018; 10 Kim, Luk, Wolfe, Kim (CR64) 2019; 88 Wang, Zhang, Gao (CR106) 2020; 181 Yeh, Richardson, Corn (CR18) 2019; 21 Moretti (CR33) 2020; 26 Gupta, Bahal, Gupta, Glazer, Saltzman (CR81) 2016; 240 Meier (CR131) 2018; 8 Moon, Kim, Ko, Kim, Kim (CR115) 2019; 37 Hou (CR69) 2013; 110 Yeh, Chiang, Rees, Edge, Liu (CR56) 2018; 9 Chatterjee (CR78) 2020; 11 High, Roncarolo (CR1) 2019; 381 Zeng (CR61) 2020; 26 Yin, Kauffman, Anderson (CR105) 2017; 16 Hilton (CR27) 2015; 33 Song (CR62) 2020; 4 Bulte (CR128) 2015; 1 Kurt (CR91) 2021; 39 CR104 Cheng, Tsai (CR141) 2018; 19 Sedic (CR42) 2018; 55 Li (CR47) 2020; 28 Stunnenberg, Hirst (CR151) 2016; 167 Yan (CR82) 2019; 363 Edraki (CR74) 2019; 73 Strecker (CR85) 2019; 365 Cong (CR11) 2013; 339 Bulte (CR122) 2019; 138 Collins, Galas (CR155) 1993; 262 Zeng (CR57) 2018; 26 Dolan (CR84) 2019; 74 Grünewald (CR89) 2020; 38 Amoasii (CR51) 2017; 9 B Zetsche (3191_CR70) 2015; 163 HA Rees (3191_CR21) 2018; 19 G Gasiunas (3191_CR9) 2012; 109 J Zeng (3191_CR61) 2020; 26 W-H Yeh (3191_CR56) 2018; 9 J Grünewald (3191_CR89) 2020; 38 JWM Bulte (3191_CR122) 2019; 138 A Moretti (3191_CR33) 2020; 26 MC Canver (3191_CR48) 2015; 527 CE Nelson (3191_CR49) 2016; 351 CT Charlesworth (3191_CR44) 2019; 25 S-M Ryu (3191_CR58) 2018; 36 W Wu (3191_CR116) 2017; 114 L Naldini (3191_CR19) 2016; 353 WX Yan (3191_CR82) 2019; 363 P Chatterjee (3191_CR78) 2020; 11 Y Cheng (3191_CR141) 2018; 19 JB Black (3191_CR95) 2018; 52 AV Anzalone (3191_CR4) 2020; 38 A Li (3191_CR47) 2020; 28 L Villiger (3191_CR54) 2018; 24 L Holtzman (3191_CR93) 2018; 19 I Minn (3191_CR121) 2019; 5 J Wang (3191_CR145) 2019; 221 M Tabebordbar (3191_CR50) 2016; 351 S Krishnamurthy (3191_CR111) 2019; 10 ML Maeder (3191_CR28) 2016; 24 AE Dolan (3191_CR84) 2019; 74 HuBMAP Consortium (3191_CR154) 2019; 574 FD Urnov (3191_CR5) 2005; 435 JB Brown (3191_CR150) 2015; 16 AC Komor (3191_CR22) 2016; 533 The ENCODE Project Consortium (3191_CR149) 2004; 306 A Khvorova (3191_CR66) 2017; 35 LB Harrington (3191_CR76) 2017; 8 PA Gammage (3191_CR99) 2018; 34 N Crosetto (3191_CR133) 2013; 10 P Cameron (3191_CR137) 2017; 14 LP Freedman (3191_CR146) 2015; 13 A Pickar-Oliver (3191_CR3) 2019; 20 DL Wagner (3191_CR45) 2019; 25 P Chatterjee (3191_CR77) 2018; 4 Z Hu (3191_CR79) 2020; 18 D Agudelo (3191_CR73) 2020; 30 NG Economos (3191_CR96) 2020; 25 L Cong (3191_CR11) 2013; 339 KM Esvelt (3191_CR68) 2013; 10 VT Chu (3191_CR117) 2015; 33 J van Haasteren (3191_CR107) 2020; 38 CE Nelson (3191_CR40) 2019; 25 MT Certo (3191_CR118) 2011; 8 D Kim (3191_CR135) 2015; 12 L Amoasii (3191_CR31) 2018; 362 A Gupta (3191_CR81) 2016; 240 P Pausch (3191_CR87) 2020; 369 C-Q Song (3191_CR62) 2020; 4 AA Dominguez (3191_CR20) 2016; 17 AF Tarantal (3191_CR130) 2010; 21 NM Gaudelli (3191_CR23) 2017; 551 IB Hilton (3191_CR27) 2015; 33 SR Ferdosi (3191_CR46) 2019; 10 Z Liu (3191_CR52) 2018; 9 SR Bacman (3191_CR102) 2018; 24 3191_CR104 P Tebas (3191_CR34) 2014; 370 NN Nyström (3191_CR132) 2019; 54 R Bahal (3191_CR98) 2016; 7 M Sedic (3191_CR42) 2018; 55 J Huang (3191_CR124) 2008; 7 CR Warren (3191_CR153) 2017; 20 X Zhang (3191_CR90) 2020; 38 M Hashimoto (3191_CR103) 2015; 23 Q Li (3191_CR55) 2018; 20 AM Moreno (3191_CR43) 2019; 3 H Yin (3191_CR105) 2017; 16 AF Tarantal (3191_CR126) 2013; 8 D Zhao (3191_CR92) 2021; 39 RC Sakata (3191_CR88) 2020; 38 EA Stadtmauer (3191_CR36) 2020; 367 AL Plant (3191_CR148) 2018; 16 BT Staahl (3191_CR113) 2017; 35 P Mali (3191_CR10) 2013; 339 H Li (3191_CR30) 2011; 475 FA Ran (3191_CR71) 2015; 520 F Collins (3191_CR155) 1993; 262 GA Truskey (3191_CR144) 2018; 18 T Wei (3191_CR109) 2020; 11 L Amoasii (3191_CR51) 2017; 9 SQ Tsai (3191_CR134) 2015; 33 E Kim (3191_CR72) 2017; 8 KA High (3191_CR1) 2019; 381 CD Yeh (3191_CR18) 2019; 21 J Strecker (3191_CR85) 2019; 365 M Minczuk (3191_CR100) 2010; 5 SW Cho (3191_CR12) 2013; 31 D Kim (3191_CR64) 2019; 88 JWM Bulte (3191_CR128) 2015; 1 J Smith (3191_CR6) 2006; 34 W-H Yeh (3191_CR60) 2020; 12 Z Hou (3191_CR69) 2013; 110 D Sürün (3191_CR63) 2020; 11 W Jiang (3191_CR15) 2013; 31 H Hirano (3191_CR75) 2016; 164 SB Moon (3191_CR115) 2019; 37 L Wang (3191_CR41) 2018; 36 NA McNeer (3191_CR97) 2015; 6 ME Perry (3191_CR67) 2018; 17 AL Pumphrey (3191_CR123) 2017; 282 AR Penheiter (3191_CR120) 2012; 12 AF Tarantal (3191_CR125) 2012; 14 WL Chew (3191_CR38) 2016; 13 JM Levy (3191_CR59) 2020; 4 AF Tarantal (3191_CR129) 2006; 17 D Burstein (3191_CR80) 2017; 542 B Zeitler (3191_CR94) 2019; 25 JD Finn (3191_CR108) 2018; 22 KS Makarova (3191_CR16) 2020; 18 P Rouet (3191_CR17) 1994; 91 ML Maeder (3191_CR32) 2019; 25 L Xu (3191_CR35) 2019; 381 SE Klompe (3191_CR86) 2019; 571 CR Lazzarotto (3191_CR138) 2018; 13 AL Plant (3191_CR147) 2014; 11 BY Mok (3191_CR24) 2020; 583 A Edraki (3191_CR74) 2019; 73 J-J Liu (3191_CR83) 2019; 566 JA Doudna (3191_CR2) 2020; 578 Y Zeng (3191_CR57) 2018; 26 WY Hwang (3191_CR13) 2013; 31 M Jinek (3191_CR14) 2013; 2 MP Zafra (3191_CR53) 2018; 36 CR Lazzarotto (3191_CR143) 2020; 38 JC Miller (3191_CR7) 2011; 29 G Chen (3191_CR112) 2019; 14 MH Porteus (3191_CR29) 2019; 380 JL Schmid-Burgk (3191_CR140) 2020; 78 D Wang (3191_CR39) 2015; 26 SQ Tsai (3191_CR136) 2017; 14 VL Simhadri (3191_CR142) 2018; 10 HG Stunnenberg (3191_CR151) 2016; 167 J Dekker (3191_CR152) 2017; 549 R Gabriel (3191_CR65) 2011; 29 AV Anzalone (3191_CR25) 2019; 576 NA Kearns (3191_CR26) 2015; 12 IC Kurt (3191_CR91) 2021; 39 PA Gammage (3191_CR101) 2018; 24 B Wienert (3191_CR139) 2019; 364 S Meier (3191_CR131) 2018; 8 AF Tarantal (3191_CR127) 2017; 28 H Yin (3191_CR110) 2017; 35 D Wang (3191_CR106) 2020; 181 H Yin (3191_CR114) 2016; 34 W Qasim (3191_CR37) 2017; 9 M Jinek (3191_CR8) 2012; 337 S Iwano (3191_CR119) 2018; 359 |
References_xml | – volume: 4 start-page: eaau0766 year: 2018 ident: CR77 article-title: Minimal PAM specificity of a highly similar SpCas9 ortholog publication-title: Sci. Adv. contributor: fullname: Jacobson – volume: 138 start-page: 293 year: 2019 end-page: 301 ident: CR122 article-title: Superparamagnetic iron oxides as MPI tracers: A primer and review of early applications publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Bulte – volume: 163 start-page: 759 year: 2015 end-page: 771 ident: CR70 article-title: Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR–Cas system publication-title: Cell contributor: fullname: Zetsche – volume: 363 start-page: 88 year: 2019 end-page: 91 ident: CR82 article-title: Functionally diverse type V CRISPR–Cas systems publication-title: Science contributor: fullname: Yan – volume: 574 start-page: 187 year: 2019 end-page: 192 ident: CR154 article-title: The human body at cellular resolution: the NIH Human Biomolecular Atlas Program publication-title: Nature – volume: 24 start-page: 1519 year: 2018 end-page: 1525 ident: CR54 article-title: Treatment of a metabolic liver disease by in vivo genome base editing in adult mice publication-title: Nat. Med. contributor: fullname: Villiger – volume: 25 start-page: 242 year: 2019 end-page: 248 ident: CR45 article-title: High prevalence of Cas9-reactive T cells within the adult human population publication-title: Nat. Med. contributor: fullname: Wagner – volume: 31 start-page: 230 year: 2013 end-page: 232 ident: CR12 article-title: Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease publication-title: Nat. Biotechnol. contributor: fullname: Kim – volume: 362 start-page: 86 year: 2018 end-page: 91 ident: CR31 article-title: Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy publication-title: Science contributor: fullname: Amoasii – volume: 583 start-page: 631 year: 2020 end-page: 637 ident: CR24 article-title: A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing publication-title: Nature contributor: fullname: Mok – volume: 9 start-page: eaaj2013 year: 2017 ident: CR37 article-title: Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells publication-title: Sci. Transl. Med. contributor: fullname: Qasim – volume: 33 start-page: 543 year: 2015 end-page: 548 ident: CR117 article-title: Increasing the efficiency of homology-directed repair for CRISPR–Cas9-induced precise gene editing in mammalian cells publication-title: Nat. Biotechnol. contributor: fullname: Chu – volume: 22 start-page: 2227 year: 2018 end-page: 2235 ident: CR108 article-title: A single administration of CRISPR/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing publication-title: Cell Rep. contributor: fullname: Finn – volume: 25 start-page: 1131 year: 2019 end-page: 1142 ident: CR94 article-title: Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease publication-title: Nat. Med. contributor: fullname: Zeitler – volume: 10 start-page: 361 year: 2013 end-page: 365 ident: CR133 article-title: Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing publication-title: Nat. Methods contributor: fullname: Crosetto – volume: 21 start-page: 1468 year: 2019 end-page: 1478 ident: CR18 article-title: Advances in genome editing through control of DNA repair pathways publication-title: Nat. Cell Biol. contributor: fullname: Corn – volume: 9 year: 2018 ident: CR56 article-title: In vivo base editing of post-mitotic sensory cells publication-title: Nat. Commun. contributor: fullname: Liu – volume: 351 start-page: 407 year: 2016 end-page: 411 ident: CR50 article-title: In vivo gene editing in dystrophic mouse muscle and muscle stem cells publication-title: Science contributor: fullname: Tabebordbar – volume: 475 start-page: 217 year: 2011 end-page: 221 ident: CR30 article-title: In vivo genome editing restores haemostasis in a mouse model of haemophilia publication-title: Nature contributor: fullname: Li – volume: 8 year: 2017 ident: CR72 article-title: In vivo genome editing with a small Cas9 orthologue derived from publication-title: Nat. Commun. contributor: fullname: Kim – volume: 10 start-page: 1116 year: 2013 end-page: 1121 ident: CR68 article-title: Orthogonal Cas9 proteins for RNA-guided gene regulation and editing publication-title: Nat. Methods contributor: fullname: Esvelt – volume: 29 start-page: 143 year: 2011 end-page: 148 ident: CR7 article-title: A TALE nuclease architecture for efficient genome editing publication-title: Nat. Biotechnol. contributor: fullname: Miller – volume: 26 start-page: 432 year: 2015 end-page: 442 ident: CR39 article-title: Adenovirus-mediated somatic genome editing of Pten by CRISPR/Cas9 in mouse liver in spite of Cas9-specific immune responses publication-title: Hum. Gene Ther. contributor: fullname: Wang – volume: 55 start-page: 341 year: 2018 end-page: 354 ident: CR42 article-title: Safety evaluation of lipid nanoparticle-formulated modified mRNA in the Sprague-Dawley rat and cynomolgus monkey publication-title: Vet. Pathol. contributor: fullname: Sedic – volume: 10 year: 2019 ident: CR111 article-title: Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia publication-title: Nat. Commun. contributor: fullname: Krishnamurthy – volume: 435 start-page: 646 year: 2005 end-page: 651 ident: CR5 article-title: Highly efficient endogenous human gene correction using designed zinc-finger nucleases publication-title: Nature contributor: fullname: Urnov – volume: 19 start-page: 43 year: 2018 end-page: 71 ident: CR93 article-title: Editing the epigenome: reshaping the genomic landscape publication-title: Annu. Rev. Genomics Hum. Genet. contributor: fullname: Gersbach – volume: 381 start-page: 1240 year: 2019 end-page: 1247 ident: CR35 article-title: CRISPR-edited stem cells in a patient with HIV and acute lymphocytic leukemia publication-title: N. Engl. J. Med. contributor: fullname: Xu – volume: 527 start-page: 192 year: 2015 end-page: 197 ident: CR48 article-title: BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis publication-title: Nature contributor: fullname: Canver – volume: 12 start-page: 33 year: 2012 end-page: 47 ident: CR120 article-title: The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies publication-title: Curr. Gene Ther. contributor: fullname: Carlson – volume: 36 start-page: 888 year: 2018 end-page: 893 ident: CR53 article-title: Optimized base editors enable efficient editing in cells, organoids and mice publication-title: Nat. Biotechnol. contributor: fullname: Zafra – volume: 25 start-page: 735 year: 2020 ident: CR96 article-title: Peptide nucleic acids and gene editing: perspectives on structure and repair publication-title: Molecules contributor: fullname: Economos – volume: 74 start-page: 936 year: 2019 end-page: 950.e5 ident: CR84 article-title: Introducing a spectrum of long-range genomic deletions in human embryonic stem cells using type I CRISPR–Cas publication-title: Mol. Cell contributor: fullname: Dolan – volume: 17 start-page: 5 year: 2016 end-page: 15 ident: CR20 article-title: Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Qi – volume: 39 start-page: 35 year: 2021 end-page: 40 ident: CR92 article-title: Glycosylase base editors enable C-to-A and C-to-G base changes publication-title: Nat. Biotechnol. contributor: fullname: Zhao – volume: 110 start-page: 15644 year: 2013 end-page: 15649 ident: CR69 article-title: Efficient genome engineering in human pluripotent stem cells using Cas9 from publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Hou – volume: 25 start-page: 249 year: 2019 end-page: 254 ident: CR44 article-title: Identification of preexisting adaptive immunity to Cas9 proteins in humans publication-title: Nat. Med. contributor: fullname: Charlesworth – volume: 20 start-page: 1315 year: 2018 end-page: 1325 ident: CR55 article-title: CRISPR–Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development publication-title: Nat. Cell Biol. contributor: fullname: Li – volume: 18 start-page: 67 year: 2020 end-page: 83 ident: CR16 article-title: Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants publication-title: Nat. Rev. Microbiol. contributor: fullname: Makarova – volume: 353 start-page: 1101 year: 2016 end-page: 1102 ident: CR19 article-title: Lentiviral vectors, two decades later publication-title: Science contributor: fullname: Verma – volume: 12 start-page: eaay9101 year: 2020 ident: CR60 article-title: In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness publication-title: Sci. Transl. Med. contributor: fullname: Yeh – volume: 11 start-page: 511 year: 2020 ident: CR63 article-title: Efficient generation and correction of mutations in human iPS cells utilizing mRNAs of CRISPR base editors and prime editors publication-title: Genes (Basel) contributor: fullname: Sürün – volume: 533 start-page: 420 year: 2016 end-page: 424 ident: CR22 article-title: Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage publication-title: Nature contributor: fullname: Liu – volume: 20 start-page: 431 year: 2017 end-page: 433 ident: CR153 article-title: The NextGen Genetic Association Studies Consortium: a foray into in vitro population genetics publication-title: Cell Stem Cell contributor: fullname: Cowan – volume: 2 start-page: e00471 year: 2013 ident: CR14 article-title: RNA-programmed genome editing in human cells publication-title: eLife contributor: fullname: Jinek – volume: 240 start-page: 302 year: 2016 end-page: 311 ident: CR81 article-title: Nanotechnology for delivery of peptide nucleic acids (PNAs) publication-title: J. Control. Release contributor: fullname: Saltzman – volume: 551 start-page: 464 year: 2017 end-page: 471 ident: CR23 article-title: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage publication-title: Nature contributor: fullname: Gaudelli – volume: 38 start-page: 856 year: 2020 end-page: 860 ident: CR90 article-title: Dual base editor catalyzes both cytosine and adenine base conversions in human cells publication-title: Nat. Biotechnol. contributor: fullname: Zhang – volume: 36 start-page: 536 year: 2018 end-page: 539 ident: CR58 article-title: Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy publication-title: Nat. Biotechnol. contributor: fullname: Ryu – volume: 21 start-page: 143 year: 2010 end-page: 148 ident: CR130 article-title: Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys ( ) publication-title: Hum. Gene Ther. contributor: fullname: Lee – volume: 339 start-page: 819 year: 2013 end-page: 823 ident: CR11 article-title: Multiplex genome engineering using CRISPR/Cas systems publication-title: Science contributor: fullname: Cong – volume: 109 start-page: E2579 year: 2012 end-page: E2586 ident: CR9 article-title: Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Siksnys – volume: 24 start-page: 430 year: 2016 end-page: 446 ident: CR28 article-title: Genome-editing technologies for gene and cell therapy publication-title: Mol. Ther. contributor: fullname: Gersbach – volume: 542 start-page: 237 year: 2017 end-page: 241 ident: CR80 article-title: New CRISPR–Cas systems from uncultivated microbes publication-title: Nature contributor: fullname: Burstein – volume: 19 year: 2018 ident: CR141 article-title: Illuminating the genome-wide activity of genome editors for safe and effective therapeutics publication-title: Genome Biol. contributor: fullname: Tsai – volume: 351 start-page: 403 year: 2016 end-page: 407 ident: CR49 article-title: In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy publication-title: Science contributor: fullname: Nelson – volume: 7 start-page: 1 year: 2008 end-page: 11 ident: CR124 article-title: Radiolabeling rhesus monkey CD34 hematopoietic and mesenchymal stem cells with Cu-pyruvaldehyde-bis( 4-methylthiosemicarbazone) for microPET imaging publication-title: Mol. Imaging contributor: fullname: Tarantal – volume: 24 start-page: 1696 year: 2018 end-page: 1700 ident: CR102 article-title: MitoTALEN reduces mutant mtDNA load and restores tRNA levels in a mouse model of heteroplasmic mtDNA mutation publication-title: Nat. Med. contributor: fullname: Bacman – volume: 35 start-page: 1179 year: 2017 end-page: 1187 ident: CR110 article-title: Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing publication-title: Nat. Biotechnol. contributor: fullname: Yin – volume: 306 start-page: 636 year: 2004 end-page: 640 ident: CR149 article-title: The ENCODE (ENCyclopedia Of DNA Elements) Project publication-title: Science – volume: 262 start-page: 43 year: 1993 end-page: 46 ident: CR155 article-title: A new five-year plan for the U.S. Human Genome Project publication-title: Science contributor: fullname: Galas – volume: 578 start-page: 229 year: 2020 end-page: 236 ident: CR2 article-title: The promise and challenge of therapeutic genome editing publication-title: Nature doi: 10.1038/s41586-020-1978-5 contributor: fullname: Doudna – volume: 7 year: 2016 ident: CR98 article-title: In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery publication-title: Nat. Commun. contributor: fullname: Bahal – volume: 16 start-page: e2004299 year: 2018 ident: CR148 article-title: How measurement science can improve confidence in research results publication-title: PLoS Biol. contributor: fullname: Plant – volume: 282 start-page: 131 year: 2017 end-page: 138 ident: CR123 article-title: Cardiac chemical exchange saturation transfer MR imaging tracking of cell survival or rejection in mouse models of cell therapy publication-title: Radiology contributor: fullname: Pumphrey – volume: 369 start-page: 333 year: 2020 end-page: 337 ident: CR87 article-title: CRISPR–CasΦ from huge phages is a hypercompact genome editor publication-title: Science contributor: fullname: Pausch – volume: 25 start-page: 427 year: 2019 end-page: 432 ident: CR40 article-title: Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy publication-title: Nat. Med. contributor: fullname: Nelson – volume: 13 start-page: e1002165 year: 2015 ident: CR146 article-title: The economics of reproducibility in preclinical research publication-title: PLoS Biol. contributor: fullname: Simcoe – volume: 17 start-page: 1254 year: 2006 end-page: 1261 ident: CR129 article-title: Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys publication-title: Hum. Gene Ther. contributor: fullname: Cherry – volume: 14 start-page: 607 year: 2017 end-page: 614 ident: CR136 article-title: CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets publication-title: Nat. Methods contributor: fullname: Tsai – volume: 14 start-page: 197 year: 2012 end-page: 204 ident: CR125 article-title: Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys publication-title: Mol. Imaging Biol. contributor: fullname: Tarantal – volume: 364 start-page: 286 year: 2019 end-page: 289 ident: CR139 article-title: Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq publication-title: Science contributor: fullname: Wienert – volume: 3 start-page: 806 year: 2019 end-page: 816 ident: CR43 article-title: Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy publication-title: Nat. Biomed. Eng. contributor: fullname: Moreno – volume: 370 start-page: 901 year: 2014 end-page: 910 ident: CR34 article-title: Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV publication-title: N. Engl. J. Med. contributor: fullname: Tebas – volume: 39 start-page: 41 year: 2021 end-page: 46 ident: CR91 article-title: CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells publication-title: Nat. Biotechnol. contributor: fullname: Kurt – volume: 11 start-page: 895 year: 2014 end-page: 898 ident: CR147 article-title: Improved reproducibility by assuring confidence in measurements in biomedical research publication-title: Nat. Methods contributor: fullname: Gallagher – volume: 566 start-page: 218 year: 2019 end-page: 223 ident: CR83 article-title: CasX enzymes comprise a distinct family of RNA-guided genome editors publication-title: Nature contributor: fullname: Liu – volume: 367 start-page: eaba7365 year: 2020 ident: CR36 article-title: CRISPR-engineered T cells in patients with refractory cancer publication-title: Science contributor: fullname: Stadtmauer – volume: 24 start-page: 1691 year: 2018 end-page: 1695 ident: CR101 article-title: Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo publication-title: Nat. Med. contributor: fullname: Gammage – volume: 38 start-page: 1317 year: 2020 end-page: 1327 ident: CR143 article-title: CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity publication-title: Nat. Biotechnol. contributor: fullname: Lazzarotto – volume: 4 start-page: 97 year: 2020 end-page: 110 ident: CR59 article-title: Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses publication-title: Nat. Biomed. Eng. contributor: fullname: Levy – volume: 164 start-page: 950 year: 2016 end-page: 961 ident: CR75 article-title: Structure and engineering of Cas9 publication-title: Cell contributor: fullname: Hirano – volume: 35 start-page: 431 year: 2017 end-page: 434 ident: CR113 article-title: Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes publication-title: Nat. Biotechnol. contributor: fullname: Staahl – volume: 23 start-page: 1592 year: 2015 end-page: 1599 ident: CR103 article-title: MitoTALEN: a general approach to reduce mutant mtDNA loads and restore oxidative phosphorylation function in mitochondrial diseases publication-title: Mol. Ther. contributor: fullname: Hashimoto – volume: 114 start-page: 1660 year: 2017 end-page: 1665 ident: CR116 article-title: Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Wu – volume: 5 start-page: eaaw5096 year: 2019 ident: CR121 article-title: Imaging CAR T cell therapy with PSMA-targeted positron emission tomography publication-title: Sci. Adv. contributor: fullname: Minn – volume: 19 start-page: 770 year: 2018 end-page: 788 ident: CR21 article-title: Base editing: precision chemistry on the genome and transcriptome of living cells publication-title: Nat. Rev. Genet. contributor: fullname: Liu – volume: 20 start-page: 490 year: 2019 end-page: 507 ident: CR3 article-title: The next generation of CRISPR–Cas technologies and applications publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Gersbach – volume: 6 year: 2015 ident: CR97 article-title: Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del in airway epithelium publication-title: Nat. Commun. contributor: fullname: McNeer – volume: 17 start-page: 689 year: 2018 end-page: 690 ident: CR67 article-title: Genome editing to ‘re-write’ wrongs publication-title: Nat. Rev. Drug Discov. contributor: fullname: Brooks – volume: 18 start-page: e3000686 year: 2020 ident: CR79 article-title: A compact Cas9 ortholog from Staphylococcus auricularis (SauriCas9) expands the DNA targeting scope publication-title: PLoS Biol. contributor: fullname: Hu – volume: 11 year: 2020 ident: CR78 article-title: A Cas9 with PAM recognition for adenine dinucleotides publication-title: Nat. Commun. contributor: fullname: Chatterjee – volume: 11 year: 2020 ident: CR109 article-title: Systemic nanoparticle delivery of CRISPR–Cas9 ribonucleoproteins for effective tissue specific genome editing publication-title: Nat. Commun. contributor: fullname: Siegwart – volume: 10 year: 2019 ident: CR46 article-title: Multifunctional CRISPR–Cas9 with engineered immunosilenced human T cell epitopes publication-title: Nat. Commun. contributor: fullname: Ferdosi – volume: 4 start-page: 125 year: 2020 end-page: 130 ident: CR62 article-title: Adenine base editing in an adult mouse model of tyrosinaemia publication-title: Nat. Biomed. Eng. contributor: fullname: Song – volume: 29 start-page: 816 year: 2011 ident: CR65 article-title: An unbiased genome-wide analysis of zinc-finger nuclease specificity publication-title: Nat. Biotechnol. contributor: fullname: Gabriel – volume: 16 start-page: 387 year: 2017 end-page: 399 ident: CR105 article-title: Delivery technologies for genome editing publication-title: Nat. Rev. Drug Discov. contributor: fullname: Anderson – volume: 14 start-page: 600 year: 2017 end-page: 606 ident: CR137 article-title: Mapping the genomic landscape of CRISPR–Cas9 cleavage publication-title: Nat. Methods contributor: fullname: Cameron – volume: 571 start-page: 219 year: 2019 end-page: 225 ident: CR86 article-title: Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration publication-title: Nature contributor: fullname: Sternberg – volume: 78 start-page: 794 year: 2020 end-page: 800.e8 ident: CR140 article-title: Highly parallel profiling of Cas9 variant specificity publication-title: Mol. Cell contributor: fullname: Schmid-Burgk – volume: 52 start-page: 13 year: 2018 end-page: 21 ident: CR95 article-title: Synthetic transcription factors for cell fate reprogramming publication-title: Curr. Opin. Genet. Dev. contributor: fullname: Gersbach – volume: 16 start-page: 31 year: 2015 end-page: 53 ident: CR150 article-title: Lessons from modENCODE publication-title: Annu. Rev. Genomics Hum. Genet. contributor: fullname: Celniker – volume: 73 start-page: 714 year: 2019 end-page: 726.e4 ident: CR74 article-title: A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing publication-title: Mol. Cell contributor: fullname: Edraki – volume: 381 start-page: 455 year: 2019 end-page: 464 ident: CR1 article-title: Gene therapy publication-title: N. Engl. J. Med. contributor: fullname: Roncarolo – volume: 337 start-page: 816 year: 2012 end-page: 821 ident: CR8 article-title: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity publication-title: Science contributor: fullname: Jinek – volume: 31 start-page: 227 year: 2013 end-page: 229 ident: CR13 article-title: Efficient genome editing in zebrafish using a CRISPR–Cas system publication-title: Nat. Biotechnol. contributor: fullname: Hwang – volume: 14 start-page: 974 year: 2019 end-page: 980 ident: CR112 article-title: A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing publication-title: Nat. Nanotechnol. contributor: fullname: Chen – volume: 9 start-page: eaan8081 year: 2017 ident: CR51 article-title: Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy publication-title: Sci. Transl. Med. contributor: fullname: Amoasii – volume: 181 start-page: 136 year: 2020 end-page: 150 ident: CR106 article-title: CRISPR-based therapeutic genome editing: strategies and in vivo delivery by AAV vectors publication-title: Cell contributor: fullname: Gao – volume: 1 start-page: 91 year: 2015 end-page: 97 ident: CR128 article-title: Quantitative “hot spot” imaging of transplanted stem cells using superparamagnetic tracers and magnetic particle imaging (MPI) publication-title: Tomography contributor: fullname: Bulte – volume: 339 start-page: 823 year: 2013 end-page: 826 ident: CR10 article-title: RNA-guided human genome engineering via Cas9 publication-title: Science contributor: fullname: Mali – volume: 28 start-page: 385 year: 2017 end-page: 391 ident: CR127 article-title: Systemic and persistent muscle gene expression in rhesus monkeys with a liver de-targeted adeno-associated virus vector publication-title: Hum. Gene Ther. contributor: fullname: Samulski – volume: 38 start-page: 865 year: 2020 end-page: 869 ident: CR88 article-title: Base editors for simultaneous introduction of C-to-T and A-to-G mutations publication-title: Nat. Biotechnol. contributor: fullname: Sakata – volume: 549 start-page: 219 year: 2017 end-page: 226 ident: CR152 article-title: The 4D nucleome project publication-title: Nature contributor: fullname: Dekker – volume: 88 start-page: 191 year: 2019 end-page: 220 ident: CR64 article-title: Evaluating and enhancing target specificity of gene-editing nucleases and deaminases publication-title: Annu. Rev. Biochem. contributor: fullname: Kim – volume: 576 start-page: 149 year: 2019 end-page: 157 ident: CR25 article-title: Search-and-replace genome editing without double-strand breaks or donor DNA publication-title: Nature contributor: fullname: Anzalone – volume: 12 start-page: 237 year: 2015 end-page: 243, 1, 243 ident: CR135 article-title: Digenome-seq: genome-wide profiling of CRISPR–Cas9 off-target effects in human cells publication-title: Nat. Methods contributor: fullname: Kim – volume: 365 start-page: 48 year: 2019 end-page: 53 ident: CR85 article-title: RNA-guided DNA insertion with CRISPR-associated transposases publication-title: Science contributor: fullname: Strecker – volume: 26 start-page: 207 year: 2020 end-page: 214 ident: CR33 article-title: Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy publication-title: Nat. Med. contributor: fullname: Moretti – volume: 13 start-page: 868 year: 2016 end-page: 874 ident: CR38 article-title: A multifunctional AAV–CRISPR–Cas9 and its host response publication-title: Nat. Methods contributor: fullname: Chew – volume: 359 start-page: 935 year: 2018 end-page: 939 ident: CR119 article-title: Single-cell bioluminescence imaging of deep tissue in freely moving animals publication-title: Science contributor: fullname: Iwano – volume: 33 start-page: 187 year: 2015 end-page: 197 ident: CR134 article-title: GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR–Cas nucleases publication-title: Nat. Biotechnol. contributor: fullname: Tsai – volume: 9 year: 2018 ident: CR52 article-title: Highly efficient RNA-guided base editing in rabbit publication-title: Nat. Commun. contributor: fullname: Liu – volume: 10 start-page: 105 year: 2018 end-page: 112 ident: CR142 article-title: Prevalence of pre-existing antibodies to CRISPR-associated nuclease Cas9 in the USA population publication-title: Mol. Ther. Methods Clin. Dev. contributor: fullname: Simhadri – volume: 221 start-page: 119416 year: 2019 ident: CR145 article-title: Engineered skeletal muscles for disease modeling and drug discovery publication-title: Biomaterials contributor: fullname: Wang – volume: 26 start-page: 535 year: 2020 end-page: 541 ident: CR61 article-title: Therapeutic base editing of human hematopoietic stem cells publication-title: Nat. Med. contributor: fullname: Zeng – volume: 35 start-page: 238 year: 2017 end-page: 248 ident: CR66 article-title: The chemical evolution of oligonucleotide therapies of clinical utility publication-title: Nat. Biotechnol. contributor: fullname: Watts – volume: 520 start-page: 186 year: 2015 end-page: 191 ident: CR71 article-title: In vivo genome editing using Cas9 publication-title: Nature contributor: fullname: Ran – volume: 31 start-page: 233 year: 2013 end-page: 239 ident: CR15 article-title: RNA-guided editing of bacterial genomes using CRISPR–Cas systems publication-title: Nat. Biotechnol. contributor: fullname: Marraffini – volume: 28 start-page: 1432 year: 2020 end-page: 1441 ident: CR47 article-title: AAV-CRISPR gene editing is negated by pre-existing immunity to Cas9 publication-title: Mol. Ther. contributor: fullname: Li – ident: CR104 – volume: 8 start-page: e77148 year: 2013 ident: CR126 article-title: Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys publication-title: PLoS ONE contributor: fullname: Cherry – volume: 5 start-page: 342 year: 2010 end-page: 356 ident: CR100 article-title: Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA publication-title: Nat. Protoc. contributor: fullname: Papworth – volume: 37 start-page: 870 year: 2019 end-page: 881 ident: CR115 article-title: Improving CRISPR genome editing by engineering guide RNAs publication-title: Trends Biotechnol. contributor: fullname: Kim – volume: 13 start-page: 2615 year: 2018 end-page: 2642 ident: CR138 article-title: Defining CRISPR–Cas9 genome-wide nuclease activities with CIRCLE-seq publication-title: Nat. Protoc. contributor: fullname: Lazzarotto – volume: 380 start-page: 947 year: 2019 end-page: 959 ident: CR29 article-title: A new class of medicines through DNA editing publication-title: N. Engl. J. Med. contributor: fullname: Porteus – volume: 38 start-page: 824 year: 2020 end-page: 844 ident: CR4 article-title: Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors publication-title: Nat. Biotechnol. contributor: fullname: Liu – volume: 34 start-page: e149 year: 2006 ident: CR6 article-title: A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences publication-title: Nucleic Acids Res. contributor: fullname: Smith – volume: 38 start-page: 845 year: 2020 end-page: 855 ident: CR107 article-title: The delivery challenge: fulfilling the promise of therapeutic genome editing publication-title: Nat. Biotechnol. contributor: fullname: Schaffer – volume: 54 start-page: 302 year: 2019 end-page: 311 ident: CR132 article-title: Longitudinal visualization of viable cancer cell intratumoral distribution in mouse models using -enhanced magnetic resonance imaging publication-title: Invest. Radiol. contributor: fullname: Nyström – volume: 8 year: 2017 ident: CR76 article-title: A thermostable Cas9 with increased lifetime in human plasma publication-title: Nat. Commun. contributor: fullname: Harrington – volume: 34 start-page: 328 year: 2016 end-page: 333 ident: CR114 article-title: Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo publication-title: Nat. Biotechnol. contributor: fullname: Yin – volume: 91 start-page: 6064 year: 1994 end-page: 6068 ident: CR17 article-title: Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Jasin – volume: 26 start-page: 2631 year: 2018 end-page: 2637 ident: CR57 article-title: Correction of the Marfan syndrome pathogenic FBN1 mutation by base editing in human cells and heterozygous embryos publication-title: Mol. Ther. contributor: fullname: Zeng – volume: 18 start-page: 3061 year: 2018 end-page: 3073 ident: CR144 article-title: Development and application of human skeletal muscle microphysiological systems publication-title: Lab Chip contributor: fullname: Truskey – volume: 167 start-page: 1145 year: 2016 end-page: 1149 ident: CR151 article-title: The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery publication-title: Cell contributor: fullname: Hirst – volume: 25 start-page: 229 year: 2019 end-page: 233 ident: CR32 article-title: Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10 publication-title: Nat. Med. contributor: fullname: Maeder – volume: 8 start-page: 671 year: 2011 end-page: 676 ident: CR118 article-title: Tracking genome engineering outcome at individual DNA breakpoints publication-title: Nat. Methods contributor: fullname: Certo – volume: 12 start-page: 401 year: 2015 end-page: 403 ident: CR26 article-title: Functional annotation of native enhancers with a Cas9–histone demethylase fusion publication-title: Nat. Methods contributor: fullname: Kearns – volume: 33 start-page: 510 year: 2015 end-page: 517 ident: CR27 article-title: Epigenome editing by a CRISPR–Cas9-based acetyltransferase activates genes from promoters and enhancers publication-title: Nat. Biotechnol. contributor: fullname: Hilton – volume: 34 start-page: 101 year: 2018 end-page: 110 ident: CR99 article-title: Mitochondrial genome engineering: the revolution may not be CRISPR-ized publication-title: Trends Genet. contributor: fullname: Minczuk – volume: 30 start-page: 107 year: 2020 end-page: 117 ident: CR73 article-title: Versatile and robust genome editing with CRISPR1–Cas9 publication-title: Genome Res. contributor: fullname: Agudelo – volume: 36 start-page: 717 year: 2018 end-page: 725 ident: CR41 article-title: Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol publication-title: Nat. Biotechnol. contributor: fullname: Wang – volume: 8 year: 2018 ident: CR131 article-title: Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart publication-title: Sci. Rep. contributor: fullname: Meier – volume: 38 start-page: 861 year: 2020 end-page: 864 ident: CR89 article-title: A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing publication-title: Nat. Biotechnol. contributor: fullname: Grünewald – volume: 362 start-page: 86 year: 2018 ident: 3191_CR31 publication-title: Science doi: 10.1126/science.aau1549 contributor: fullname: L Amoasii – volume: 138 start-page: 293 year: 2019 ident: 3191_CR122 publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2018.12.007 contributor: fullname: JWM Bulte – volume: 381 start-page: 1240 year: 2019 ident: 3191_CR35 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1817426 contributor: fullname: L Xu – volume: 26 start-page: 535 year: 2020 ident: 3191_CR61 publication-title: Nat. Med. doi: 10.1038/s41591-020-0790-y contributor: fullname: J Zeng – volume: 369 start-page: 333 year: 2020 ident: 3191_CR87 publication-title: Science doi: 10.1126/science.abb1400 contributor: fullname: P Pausch – volume: 3 start-page: 806 year: 2019 ident: 3191_CR43 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-019-0431-2 contributor: fullname: AM Moreno – volume: 26 start-page: 432 year: 2015 ident: 3191_CR39 publication-title: Hum. Gene Ther. doi: 10.1089/hum.2015.087 contributor: fullname: D Wang – volume: 351 start-page: 403 year: 2016 ident: 3191_CR49 publication-title: Science doi: 10.1126/science.aad5143 contributor: fullname: CE Nelson – volume: 25 start-page: 249 year: 2019 ident: 3191_CR44 publication-title: Nat. Med. doi: 10.1038/s41591-018-0326-x contributor: fullname: CT Charlesworth – volume: 36 start-page: 717 year: 2018 ident: 3191_CR41 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4182 contributor: fullname: L Wang – volume: 10 year: 2019 ident: 3191_CR46 publication-title: Nat. Commun. doi: 10.1038/s41467-019-09693-x contributor: fullname: SR Ferdosi – volume: 221 start-page: 119416 year: 2019 ident: 3191_CR145 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2019.119416 contributor: fullname: J Wang – volume: 8 year: 2018 ident: 3191_CR131 publication-title: Sci. Rep. doi: 10.1038/s41598-018-22993-4 contributor: fullname: S Meier – volume: 25 start-page: 1131 year: 2019 ident: 3191_CR94 publication-title: Nat. Med. doi: 10.1038/s41591-019-0478-3 contributor: fullname: B Zeitler – volume: 109 start-page: E2579 year: 2012 ident: 3191_CR9 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1208507109 contributor: fullname: G Gasiunas – volume: 31 start-page: 230 year: 2013 ident: 3191_CR12 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2507 contributor: fullname: SW Cho – volume: 20 start-page: 1315 year: 2018 ident: 3191_CR55 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-018-0202-4 contributor: fullname: Q Li – volume: 25 start-page: 427 year: 2019 ident: 3191_CR40 publication-title: Nat. Med. doi: 10.1038/s41591-019-0344-3 contributor: fullname: CE Nelson – volume: 39 start-page: 41 year: 2021 ident: 3191_CR91 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0609-x contributor: fullname: IC Kurt – volume: 91 start-page: 6064 year: 1994 ident: 3191_CR17 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.91.13.6064 contributor: fullname: P Rouet – volume: 339 start-page: 823 year: 2013 ident: 3191_CR10 publication-title: Science doi: 10.1126/science.1232033 contributor: fullname: P Mali – volume: 578 start-page: 229 year: 2020 ident: 3191_CR2 publication-title: Nature doi: 10.1038/s41586-020-1978-5 contributor: fullname: JA Doudna – volume: 2 start-page: e00471 year: 2013 ident: 3191_CR14 publication-title: eLife doi: 10.7554/eLife.00471 contributor: fullname: M Jinek – volume: 36 start-page: 536 year: 2018 ident: 3191_CR58 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4148 contributor: fullname: S-M Ryu – volume: 576 start-page: 149 year: 2019 ident: 3191_CR25 publication-title: Nature doi: 10.1038/s41586-019-1711-4 contributor: fullname: AV Anzalone – volume: 367 start-page: eaba7365 year: 2020 ident: 3191_CR36 publication-title: Science doi: 10.1126/science.aba7365 contributor: fullname: EA Stadtmauer – volume: 1 start-page: 91 year: 2015 ident: 3191_CR128 publication-title: Tomography doi: 10.18383/j.tom.2015.00172 contributor: fullname: JWM Bulte – volume: 475 start-page: 217 year: 2011 ident: 3191_CR30 publication-title: Nature doi: 10.1038/nature10177 contributor: fullname: H Li – volume: 31 start-page: 227 year: 2013 ident: 3191_CR13 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2501 contributor: fullname: WY Hwang – volume: 78 start-page: 794 year: 2020 ident: 3191_CR140 publication-title: Mol. Cell doi: 10.1016/j.molcel.2020.02.023 contributor: fullname: JL Schmid-Burgk – volume: 181 start-page: 136 year: 2020 ident: 3191_CR106 publication-title: Cell doi: 10.1016/j.cell.2020.03.023 contributor: fullname: D Wang – volume: 363 start-page: 88 year: 2019 ident: 3191_CR82 publication-title: Science doi: 10.1126/science.aav7271 contributor: fullname: WX Yan – volume: 364 start-page: 286 year: 2019 ident: 3191_CR139 publication-title: Science doi: 10.1126/science.aav9023 contributor: fullname: B Wienert – volume: 25 start-page: 242 year: 2019 ident: 3191_CR45 publication-title: Nat. Med. doi: 10.1038/s41591-018-0204-6 contributor: fullname: DL Wagner – volume: 6 year: 2015 ident: 3191_CR97 publication-title: Nat. Commun. doi: 10.1038/ncomms7952 contributor: fullname: NA McNeer – volume: 22 start-page: 2227 year: 2018 ident: 3191_CR108 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.02.014 contributor: fullname: JD Finn – volume: 35 start-page: 431 year: 2017 ident: 3191_CR113 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3806 contributor: fullname: BT Staahl – volume: 10 start-page: 105 year: 2018 ident: 3191_CR142 publication-title: Mol. Ther. Methods Clin. Dev. doi: 10.1016/j.omtm.2018.06.006 contributor: fullname: VL Simhadri – volume: 13 start-page: e1002165 year: 2015 ident: 3191_CR146 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1002165 contributor: fullname: LP Freedman – volume: 167 start-page: 1145 year: 2016 ident: 3191_CR151 publication-title: Cell doi: 10.1016/j.cell.2016.11.007 contributor: fullname: HG Stunnenberg – volume: 435 start-page: 646 year: 2005 ident: 3191_CR5 publication-title: Nature doi: 10.1038/nature03556 contributor: fullname: FD Urnov – volume: 24 start-page: 430 year: 2016 ident: 3191_CR28 publication-title: Mol. Ther. doi: 10.1038/mt.2016.10 contributor: fullname: ML Maeder – volume: 33 start-page: 187 year: 2015 ident: 3191_CR134 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3117 contributor: fullname: SQ Tsai – volume: 9 year: 2018 ident: 3191_CR56 publication-title: Nat. Commun. contributor: fullname: W-H Yeh – volume: 566 start-page: 218 year: 2019 ident: 3191_CR83 publication-title: Nature doi: 10.1038/s41586-019-0908-x contributor: fullname: J-J Liu – volume: 11 start-page: 895 year: 2014 ident: 3191_CR147 publication-title: Nat. Methods doi: 10.1038/nmeth.3076 contributor: fullname: AL Plant – volume: 12 start-page: eaay9101 year: 2020 ident: 3191_CR60 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aay9101 contributor: fullname: W-H Yeh – volume: 4 start-page: eaau0766 year: 2018 ident: 3191_CR77 publication-title: Sci. Adv. doi: 10.1126/sciadv.aau0766 contributor: fullname: P Chatterjee – volume: 30 start-page: 107 year: 2020 ident: 3191_CR73 publication-title: Genome Res. doi: 10.1101/gr.255414.119 contributor: fullname: D Agudelo – volume: 353 start-page: 1101 year: 2016 ident: 3191_CR19 publication-title: Science doi: 10.1126/science.aah6192 contributor: fullname: L Naldini – volume: 18 start-page: 3061 year: 2018 ident: 3191_CR144 publication-title: Lab Chip doi: 10.1039/C8LC00553B contributor: fullname: GA Truskey – volume: 9 start-page: eaan8081 year: 2017 ident: 3191_CR51 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aan8081 contributor: fullname: L Amoasii – volume: 88 start-page: 191 year: 2019 ident: 3191_CR64 publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-013118-111730 contributor: fullname: D Kim – volume: 34 start-page: 101 year: 2018 ident: 3191_CR99 publication-title: Trends Genet. doi: 10.1016/j.tig.2017.11.001 contributor: fullname: PA Gammage – volume: 339 start-page: 819 year: 2013 ident: 3191_CR11 publication-title: Science doi: 10.1126/science.1231143 contributor: fullname: L Cong – volume: 533 start-page: 420 year: 2016 ident: 3191_CR22 publication-title: Nature doi: 10.1038/nature17946 contributor: fullname: AC Komor – volume: 25 start-page: 735 year: 2020 ident: 3191_CR96 publication-title: Molecules doi: 10.3390/molecules25030735 contributor: fullname: NG Economos – volume: 16 start-page: e2004299 year: 2018 ident: 3191_CR148 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.2004299 contributor: fullname: AL Plant – volume: 549 start-page: 219 year: 2017 ident: 3191_CR152 publication-title: Nature doi: 10.1038/nature23884 contributor: fullname: J Dekker – volume: 381 start-page: 455 year: 2019 ident: 3191_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1706910 contributor: fullname: KA High – ident: 3191_CR104 doi: 10.1101/287342 – volume: 370 start-page: 901 year: 2014 ident: 3191_CR34 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1300662 contributor: fullname: P Tebas – volume: 34 start-page: 328 year: 2016 ident: 3191_CR114 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3471 contributor: fullname: H Yin – volume: 17 start-page: 1254 year: 2006 ident: 3191_CR129 publication-title: Hum. Gene Ther. doi: 10.1089/hum.2006.17.1254 contributor: fullname: AF Tarantal – volume: 26 start-page: 207 year: 2020 ident: 3191_CR33 publication-title: Nat. Med. doi: 10.1038/s41591-019-0738-2 contributor: fullname: A Moretti – volume: 19 year: 2018 ident: 3191_CR141 publication-title: Genome Biol. contributor: fullname: Y Cheng – volume: 38 start-page: 1317 year: 2020 ident: 3191_CR143 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0555-7 contributor: fullname: CR Lazzarotto – volume: 4 start-page: 125 year: 2020 ident: 3191_CR62 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-019-0357-8 contributor: fullname: C-Q Song – volume: 10 start-page: 361 year: 2013 ident: 3191_CR133 publication-title: Nat. Methods doi: 10.1038/nmeth.2408 contributor: fullname: N Crosetto – volume: 38 start-page: 856 year: 2020 ident: 3191_CR90 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0527-y contributor: fullname: X Zhang – volume: 240 start-page: 302 year: 2016 ident: 3191_CR81 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2016.01.005 contributor: fullname: A Gupta – volume: 24 start-page: 1519 year: 2018 ident: 3191_CR54 publication-title: Nat. Med. doi: 10.1038/s41591-018-0209-1 contributor: fullname: L Villiger – volume: 39 start-page: 35 year: 2021 ident: 3191_CR92 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0592-2 contributor: fullname: D Zhao – volume: 110 start-page: 15644 year: 2013 ident: 3191_CR69 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1313587110 contributor: fullname: Z Hou – volume: 26 start-page: 2631 year: 2018 ident: 3191_CR57 publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2018.08.007 contributor: fullname: Y Zeng – volume: 13 start-page: 2615 year: 2018 ident: 3191_CR138 publication-title: Nat. Protoc. doi: 10.1038/s41596-018-0055-0 contributor: fullname: CR Lazzarotto – volume: 9 start-page: eaaj2013 year: 2017 ident: 3191_CR37 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaj2013 contributor: fullname: W Qasim – volume: 11 start-page: 511 year: 2020 ident: 3191_CR63 publication-title: Genes (Basel) doi: 10.3390/genes11050511 contributor: fullname: D Sürün – volume: 12 start-page: 401 year: 2015 ident: 3191_CR26 publication-title: Nat. Methods doi: 10.1038/nmeth.3325 contributor: fullname: NA Kearns – volume: 38 start-page: 845 year: 2020 ident: 3191_CR107 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0565-5 contributor: fullname: J van Haasteren – volume: 14 start-page: 607 year: 2017 ident: 3191_CR136 publication-title: Nat. Methods doi: 10.1038/nmeth.4278 contributor: fullname: SQ Tsai – volume: 73 start-page: 714 year: 2019 ident: 3191_CR74 publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.12.003 contributor: fullname: A Edraki – volume: 527 start-page: 192 year: 2015 ident: 3191_CR48 publication-title: Nature doi: 10.1038/nature15521 contributor: fullname: MC Canver – volume: 38 start-page: 861 year: 2020 ident: 3191_CR89 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0535-y contributor: fullname: J Grünewald – volume: 35 start-page: 238 year: 2017 ident: 3191_CR66 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3765 contributor: fullname: A Khvorova – volume: 55 start-page: 341 year: 2018 ident: 3191_CR42 publication-title: Vet. Pathol. doi: 10.1177/0300985817738095 contributor: fullname: M Sedic – volume: 337 start-page: 816 year: 2012 ident: 3191_CR8 publication-title: Science doi: 10.1126/science.1225829 contributor: fullname: M Jinek – volume: 9 year: 2018 ident: 3191_CR52 publication-title: Nat. Commun. contributor: fullname: Z Liu – volume: 164 start-page: 950 year: 2016 ident: 3191_CR75 publication-title: Cell doi: 10.1016/j.cell.2016.01.039 contributor: fullname: H Hirano – volume: 551 start-page: 464 year: 2017 ident: 3191_CR23 publication-title: Nature doi: 10.1038/nature24644 contributor: fullname: NM Gaudelli – volume: 11 year: 2020 ident: 3191_CR109 publication-title: Nat. Commun. contributor: fullname: T Wei – volume: 351 start-page: 407 year: 2016 ident: 3191_CR50 publication-title: Science doi: 10.1126/science.aad5177 contributor: fullname: M Tabebordbar – volume: 8 year: 2017 ident: 3191_CR76 publication-title: Nat. Commun. doi: 10.1038/s41467-017-01408-4 contributor: fullname: LB Harrington – volume: 262 start-page: 43 year: 1993 ident: 3191_CR155 publication-title: Science doi: 10.1126/science.8211127 contributor: fullname: F Collins – volume: 29 start-page: 816 year: 2011 ident: 3191_CR65 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1948 contributor: fullname: R Gabriel – volume: 163 start-page: 759 year: 2015 ident: 3191_CR70 publication-title: Cell doi: 10.1016/j.cell.2015.09.038 contributor: fullname: B Zetsche – volume: 33 start-page: 510 year: 2015 ident: 3191_CR27 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3199 contributor: fullname: IB Hilton – volume: 16 start-page: 387 year: 2017 ident: 3191_CR105 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2016.280 contributor: fullname: H Yin – volume: 380 start-page: 947 year: 2019 ident: 3191_CR29 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1800729 contributor: fullname: MH Porteus – volume: 36 start-page: 888 year: 2018 ident: 3191_CR53 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4194 contributor: fullname: MP Zafra – volume: 19 start-page: 43 year: 2018 ident: 3191_CR93 publication-title: Annu. Rev. Genomics Hum. Genet. doi: 10.1146/annurev-genom-083117-021632 contributor: fullname: L Holtzman – volume: 19 start-page: 770 year: 2018 ident: 3191_CR21 publication-title: Nat. Rev. Genet. doi: 10.1038/s41576-018-0059-1 contributor: fullname: HA Rees – volume: 38 start-page: 865 year: 2020 ident: 3191_CR88 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0509-0 contributor: fullname: RC Sakata – volume: 37 start-page: 870 year: 2019 ident: 3191_CR115 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2019.01.009 contributor: fullname: SB Moon – volume: 8 year: 2017 ident: 3191_CR72 publication-title: Nat. Commun. contributor: fullname: E Kim – volume: 7 start-page: 1 year: 2008 ident: 3191_CR124 publication-title: Mol. Imaging doi: 10.2310/7290.2008.00001 contributor: fullname: J Huang – volume: 21 start-page: 1468 year: 2019 ident: 3191_CR18 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0425-z contributor: fullname: CD Yeh – volume: 12 start-page: 33 year: 2012 ident: 3191_CR120 publication-title: Curr. Gene Ther. doi: 10.2174/156652312799789235 contributor: fullname: AR Penheiter – volume: 542 start-page: 237 year: 2017 ident: 3191_CR80 publication-title: Nature doi: 10.1038/nature21059 contributor: fullname: D Burstein – volume: 13 start-page: 868 year: 2016 ident: 3191_CR38 publication-title: Nat. Methods doi: 10.1038/nmeth.3993 contributor: fullname: WL Chew – volume: 17 start-page: 689 year: 2018 ident: 3191_CR67 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2018.91 contributor: fullname: ME Perry – volume: 14 start-page: 974 year: 2019 ident: 3191_CR112 publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-019-0539-2 contributor: fullname: G Chen – volume: 18 start-page: 67 year: 2020 ident: 3191_CR16 publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-019-0299-x contributor: fullname: KS Makarova – volume: 34 start-page: e149 year: 2006 ident: 3191_CR6 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl720 contributor: fullname: J Smith – volume: 31 start-page: 233 year: 2013 ident: 3191_CR15 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2508 contributor: fullname: W Jiang – volume: 12 start-page: 237 year: 2015 ident: 3191_CR135 publication-title: Nat. Methods doi: 10.1038/nmeth.3284 contributor: fullname: D Kim – volume: 21 start-page: 143 year: 2010 ident: 3191_CR130 publication-title: Hum. Gene Ther. doi: 10.1089/hum.2009.126 contributor: fullname: AF Tarantal – volume: 8 start-page: 671 year: 2011 ident: 3191_CR118 publication-title: Nat. Methods doi: 10.1038/nmeth.1648 contributor: fullname: MT Certo – volume: 38 start-page: 824 year: 2020 ident: 3191_CR4 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0561-9 contributor: fullname: AV Anzalone – volume: 11 year: 2020 ident: 3191_CR78 publication-title: Nat. Commun. contributor: fullname: P Chatterjee – volume: 24 start-page: 1691 year: 2018 ident: 3191_CR101 publication-title: Nat. Med. doi: 10.1038/s41591-018-0165-9 contributor: fullname: PA Gammage – volume: 10 year: 2019 ident: 3191_CR111 publication-title: Nat. Commun. doi: 10.1038/s41467-019-12922-y contributor: fullname: S Krishnamurthy – volume: 16 start-page: 31 year: 2015 ident: 3191_CR150 publication-title: Annu. Rev. Genomics Hum. Genet. doi: 10.1146/annurev-genom-090413-025448 contributor: fullname: JB Brown – volume: 5 start-page: 342 year: 2010 ident: 3191_CR100 publication-title: Nat. Protoc. doi: 10.1038/nprot.2009.245 contributor: fullname: M Minczuk – volume: 24 start-page: 1696 year: 2018 ident: 3191_CR102 publication-title: Nat. Med. doi: 10.1038/s41591-018-0166-8 contributor: fullname: SR Bacman – volume: 35 start-page: 1179 year: 2017 ident: 3191_CR110 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4005 contributor: fullname: H Yin – volume: 8 start-page: e77148 year: 2013 ident: 3191_CR126 publication-title: PLoS ONE doi: 10.1371/journal.pone.0077148 contributor: fullname: AF Tarantal – volume: 571 start-page: 219 year: 2019 ident: 3191_CR86 publication-title: Nature doi: 10.1038/s41586-019-1323-z contributor: fullname: SE Klompe – volume: 114 start-page: 1660 year: 2017 ident: 3191_CR116 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1614775114 contributor: fullname: W Wu – volume: 306 start-page: 636 year: 2004 ident: 3191_CR149 publication-title: Science doi: 10.1126/science.1105136 contributor: fullname: The ENCODE Project Consortium – volume: 20 start-page: 431 year: 2017 ident: 3191_CR153 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2017.03.021 contributor: fullname: CR Warren – volume: 28 start-page: 1432 year: 2020 ident: 3191_CR47 publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2020.04.017 contributor: fullname: A Li – volume: 365 start-page: 48 year: 2019 ident: 3191_CR85 publication-title: Science doi: 10.1126/science.aax9181 contributor: fullname: J Strecker – volume: 583 start-page: 631 year: 2020 ident: 3191_CR24 publication-title: Nature doi: 10.1038/s41586-020-2477-4 contributor: fullname: BY Mok – volume: 4 start-page: 97 year: 2020 ident: 3191_CR59 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-019-0501-5 contributor: fullname: JM Levy – volume: 7 year: 2016 ident: 3191_CR98 publication-title: Nat. Commun. doi: 10.1038/ncomms13304 contributor: fullname: R Bahal – volume: 5 start-page: eaaw5096 year: 2019 ident: 3191_CR121 publication-title: Sci. Adv. doi: 10.1126/sciadv.aaw5096 contributor: fullname: I Minn – volume: 17 start-page: 5 year: 2016 ident: 3191_CR20 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2015.2 contributor: fullname: AA Dominguez – volume: 282 start-page: 131 year: 2017 ident: 3191_CR123 publication-title: Radiology doi: 10.1148/radiol.2016152766 contributor: fullname: AL Pumphrey – volume: 74 start-page: 936 year: 2019 ident: 3191_CR84 publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.03.014 contributor: fullname: AE Dolan – volume: 54 start-page: 302 year: 2019 ident: 3191_CR132 publication-title: Invest. Radiol. doi: 10.1097/RLI.0000000000000542 contributor: fullname: NN Nyström – volume: 33 start-page: 543 year: 2015 ident: 3191_CR117 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3198 contributor: fullname: VT Chu – volume: 23 start-page: 1592 year: 2015 ident: 3191_CR103 publication-title: Mol. Ther. doi: 10.1038/mt.2015.126 contributor: fullname: M Hashimoto – volume: 20 start-page: 490 year: 2019 ident: 3191_CR3 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-019-0131-5 contributor: fullname: A Pickar-Oliver – volume: 29 start-page: 143 year: 2011 ident: 3191_CR7 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1755 contributor: fullname: JC Miller – volume: 25 start-page: 229 year: 2019 ident: 3191_CR32 publication-title: Nat. Med. doi: 10.1038/s41591-018-0327-9 contributor: fullname: ML Maeder – volume: 18 start-page: e3000686 year: 2020 ident: 3191_CR79 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000686 contributor: fullname: Z Hu – volume: 52 start-page: 13 year: 2018 ident: 3191_CR95 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2018.05.001 contributor: fullname: JB Black – volume: 28 start-page: 385 year: 2017 ident: 3191_CR127 publication-title: Hum. Gene Ther. doi: 10.1089/hum.2016.130 contributor: fullname: AF Tarantal – volume: 574 start-page: 187 year: 2019 ident: 3191_CR154 publication-title: Nature doi: 10.1038/s41586-019-1629-x contributor: fullname: HuBMAP Consortium – volume: 359 start-page: 935 year: 2018 ident: 3191_CR119 publication-title: Science doi: 10.1126/science.aaq1067 contributor: fullname: S Iwano – volume: 14 start-page: 197 year: 2012 ident: 3191_CR125 publication-title: Mol. Imaging Biol. doi: 10.1007/s11307-011-0487-1 contributor: fullname: AF Tarantal – volume: 10 start-page: 1116 year: 2013 ident: 3191_CR68 publication-title: Nat. Methods doi: 10.1038/nmeth.2681 contributor: fullname: KM Esvelt – volume: 520 start-page: 186 year: 2015 ident: 3191_CR71 publication-title: Nature doi: 10.1038/nature14299 contributor: fullname: FA Ran – volume: 14 start-page: 600 year: 2017 ident: 3191_CR137 publication-title: Nat. Methods doi: 10.1038/nmeth.4284 contributor: fullname: P Cameron |
SSID | ssj0005174 |
Score | 2.6358879 |
SecondaryResourceType | review_article |
Snippet | The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH)... Abstract The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health... |
SourceID | pubmedcentral osti proquest crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 195 |
SubjectTerms | 13/100 13/107 42/100 42/44 45/41 59/57 59/78 631/61/201/2110 64/60 692/308/2056 Animal models Animals BASIC BIOLOGICAL SCIENCES Biomedical materials Cells - metabolism Consortia CRISPR Deoxyribonucleic acid DNA Editing Enzymes Gene Editing - methods Gene therapy Genetic Therapy Genome editing Genome, Human - genetics Genomes Goals Humanities and Social Sciences Humans In vivo methods and tests Mitochondrial DNA multidisciplinary Mutation National Institutes of Health (U.S.) - organization & administration Patients Perspective Science Science (multidisciplinary) Sickle cell disease Somatic cells Toolkits United States |
SummonAdditionalLinks | – databaseName: Public Health Database dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9QwDLbgJiReJjZ-lY0pSDyAIFqbpG3uaUKnTQcSe4FJe4tSNxWTRjvo7f-fncvduA14dh4Sx46_xF9sgLdTCmttGZRsMe8kRzxpbYGys12FpUZVWf47_PW0mp-ZL-fleXpwGxOtcnUmxoO6HZDfyA8ZCmvLWbejq1-Su0ZxdjW10HgIWwUZJrdusLM_KB53qjCnTzO5tocjBS7L9FsmFNGdRRYbgWkykIP9DXTe507eSaDGuHTyBLYToBSflhawAw9CvwuPIrETx13YSc47inepwvT7p8A8C3H6eS6-DbFiq5iFy0tB8uFnEMftBVOhRWJuPYOzk-Pvs7lMXRMklnmxkKbTFd080U59pesaG9Vg1ZaagEsIhL60zT0_dHQkaHzrMdjOeqU80rmHtdbPYdIPfXgJItgmN1iXGOrOoGm98or06KvWe2NUl8GHlcrc1bI4hotJbW3dUsGOFOyigl2RwR5r1VFo5_q0yEQeXDiCGOXUkHR_pWyX3Gh0t5uewZu1mByAsxq-D8N1HBN_9E9tBi-We7OeDC2W4FNRZlBv7Np6ABfX3pT0Fz9ikW1Ll1Oy3Aw-rvb3dlr_XuOr_69iDx6raHKG7HEfJovf1-E1gZpFcxAt9wab9O-T priority: 102 providerName: ProQuest |
Title | The NIH Somatic Cell Genome Editing program |
URI | https://link.springer.com/article/10.1038/s41586-021-03191-1 https://www.ncbi.nlm.nih.gov/pubmed/33828315 https://www.proquest.com/docview/2511387503 https://www.proquest.com/docview/2510254398 https://www.osti.gov/servlets/purl/1815941 https://pubmed.ncbi.nlm.nih.gov/PMC8026397 |
Volume | 592 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED9BJyRepm18hW2VkXgAQUTir7iPa9RSkKgQMKlvluM4YtKWTGv3_3Pnpp06xgMvycNZkX13zt3lfv4F4O0Iw1qtAk9rnzUpRbzUmNynjWm0V8Jzbejs8Le5np3Lrwu16Gly6CzMTv9emE9LDDCGYLIE_MHaIsVKZ0_lOiMPLnV5B-e4x7jcH5B5-Bk7QWjQ4WZ6KMH8Gyd5r1kaY9D0APb75JGdra19CI9CewRPIojTL4_gsN-oS_auZ5N-_wwIU8HmX2bsZxfZWVkZLi8ZyrurwCb1BcGeWY_Seg7n08mvcpb2f0hIvcryVSobobHK9GbktCgKX_HK61oJTFJCwExLmMzRR40GBZWrnQ-mMY5z5_Ed5wshXsCg7drwClgwVSZ9oXwoGull7bjjqEena-ek5E0CHzYqs9drIgwbG9jC2LWCLSrYRgXbPIFj0qrFME5ctJ5AO35lMZ1QI4nSk42ybb9llpZqHWGorZrAm60YnZ06GK4N3W0cE0_vj0wCL9e22U4GF4upUq4SKHasth1ARNq7kvbidyTUNliIopcm8HFj37tp_XuNr_9v-DE85dEFJfrnCQxWN7fhFBOaVTWEx8WiwKspc7pOPw9h72w6Hs_xPp7Mv_8YRl__A6l77l4 |
link.rule.ids | 230,315,786,790,891,12083,12250,12792,21416,27955,27956,31752,31753,33299,33300,33406,33407,33777,33778,41153,42222,43343,43612,43633,43838,51609,74100,74369,74390,74657 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dTxQxEJ_oEaMvRFBhAbUmPmi0Ybft7vaejJIjh8LFKCS8Nd3ZbiDBXWCP_99pr3eXw4_n6UM7H51p59dfAd4OKa3VuRO8xrThPuNxrTPkjW4KzCWKQvu3wyeTYnymvp7n5_HCrY-wyvmeGDbqukN_R77vS2Gpfdft0_UN979G-e5q_ELjIax5yk09gLUvo8n3H0uQxz0e5vhsJpV6v6fUpT0A10OK6NTCs5XUNOgoxP5Wdv6JnrzXQg2Z6fAprMeSkn2e-cAGPHDtJjwK0E7sN2Ejhm_P3kWO6ffPwCMt2ORozH52gbOVHbirK0by7pdjo_rSg6FZxG49h7PD0enBmMd_EzjmaTblqpEFnT1RD20hyxIrUWFR55JKF-eo_pI6tf6qoyFBZWuLTjfaCmGRdj4spXwBg7Zr3TYwp6tUYZmjKxuFqrbCCtKjLWprlRJNAh_mKjPXM3oME9raUpuZgg0p2AQFmyyBXa9VQ8ndM9Sih_Lg1FCRkQ8VSffmyjYxkHqzNHsCbxZiCgHf17Ct6-7CmPCmf6gT2JrZZjEZWiwVUFmeQLlitcUAT6-9KmkvLwLNtqbjKfluAh_n9l1O699r3Pn_Kl7D4_HpybE5Ppp824UnIrifIt_cg8H09s69pBJnWr2KfvwbkzP0Jw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NbxMxEB1BEIgLogXK0gJG4gACK7u2d9c5IRQapXxESFCpN8s7a4tKZbew6f9n7DgpKR_n8cEeP3uePc9jgOcTCmtt6QRvMfc8RDyudYHca19hKVFUOrwd_rSo5sfq_Ul5kvRPQ5JVrvfEuFG3PYY78nGgwlKHrNvYJ1nE53ezN-c_ePhBKmRa03ca1-EGRcUqIFxPf5N7XKnInB7Q5FKPBwpiOkhxg7iIzi-82ApSo54W298I6J86yivJ1BijZnfhTiKX7O0KDTtwzXW7cDOKPHHYhZ20kAf2IlWbfnkPguaCLY7m7Esfq7eyqTs7Y2Tvvzt22J4GWTRLKq77cDw7_Dqd8_SDAscyL5ZceVnRKRT1xFayrrERDVZtKYnEOEdMTOrchksPT4bGthad9toKYZH2QKylfACjru_cQ2BON7nCukRXe4WqtcIK8qOtWmuVEj6DV2uXmfNVoQwTE9xSm5WDDTnYRAebIoP94FVDYT7UqsUg6sGlIbpRThRZD9bONmlJDeYSABk825hpMYQMh-1cfxHbxNf9E53B3mpuNp2hwRKVKsoM6q1Z2zQIhba3Ld3pt1hwW9NBlVCcwev1_F52699jfPT_UTyFWwRg8_Fo8WEfbouIPkXQPIDR8ueFe0xcZ9k8iSD-BdA99sE |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+NIH+Somatic+Cell+Genome+Editing+program&rft.jtitle=Nature+%28London%29&rft.au=Saha%2C+Krishanu&rft.au=Sontheimer%2C+Erik+J.&rft.au=Brooks%2C+P.+J.&rft.au=Dwinell%2C+Melinda+R.&rft.date=2021-04-08&rft.pub=Nature+Publishing+Group+UK&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=592&rft.issue=7853&rft.spage=195&rft.epage=204&rft_id=info:doi/10.1038%2Fs41586-021-03191-1&rft.externalDocID=10_1038_s41586_021_03191_1 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |