Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 12; pp. 1931 - 1935
• Main Authors: Ai, Kai-Xing, Lu, Lin-Yuan, Huang, Xin-Yu, Chen, Wei, Zhang, Hui-Zhen
• Format: Journal Article
• Language: English
• Published: United States Department of General Surgery, 6th Affiliated Hospital of Shanghai Jiaotong University,Shanghai 200233,China%Department of Pathology, 6th Affiliated Hospital of Shanghai Jiaotong University,Shanghai 200233,China 28.03.2008; The WJG Press and Baishideng
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Female; Humans; Male; Middle Aged; Multivariate Analysis; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Prognosis; Rapid Communication; S100 Calcium-Binding Protein A4; S100 Proteins - genetics; S100 Proteins - metabolism; Survival Rate; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; 免疫组织化学; 胰腺癌; 脉管生长因子; Immunohistochemistry; S100A4; Prognosis; Vascular endothelial growth factor; Pancreatic cancer
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.1931

AIM： To investigate the expression of vascular endothelial growth factor （VEGF） and calcium-binding protein S100A4 in pancreatic cancer and their relationship to the clinicopathological parameters and prognosis of pancreatic cancer. METHODS： Expression status of VEGF and S100A4 was examined in 62 surgical specimens of primary pancreatic cancer by immunohistochemistry. Correlation between the expression of VEGF and S100A4 and clinicopathological parameters was analyzed. RESULTS： Thirty-eight of 62 （61.3%） specimens of primary pancreatic cancer were positive for S100A4. Thirty-seven （59.7%） specimens showed positive expression of VEGF. The positive correlation between S100A4 and VEGF expression was significant in cancer tissues （P 〈 0.001）. S100A4 expression was significantly correlated with tumor size, TNM stage and poorer prognosis. VEGF expression had a significant correlation with poorer prognosis. The prognosis of 17 S100A4- and VEGF-negative cancer patients was significantly better than that of other patients （P 〈 0.05）. Distant metastasis （P = 0.001）, S100A4- （P = 0.008） and VEGF-positive expression （P = 0.016） were significantly independent prognostic predictors （P 〈 0.05）. CONCLUSION： Over-expression of S100A4 and VEGF plays an important role in the development of pancreatic cancer. Combined examination of the two molecules might be useful in evaluating the outcome of patients with pancreatic cancer.