Porphyromonas gingivalis Strain Variability and Periodontitis

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Published inJournal of Clinical Microbiology Vol. 37; no. 12; pp. 4028 - 4033
Main Authors Griffen, Ann L., Lyons, Sharon R., Becker, Mitzi R., Moeschberger, Melvin L., Leys, Eugene J.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.1999
Subjects
Adult
Bacterial diseases
Bacteriology
Bacteroidaceae Infections - microbiology
Biological and medical sciences
DNA, Bacterial - genetics
DNA, Ribosomal - genetics
Ent and stomatologic bacterial diseases
Fundamental and applied biological sciences. Psychology
Genetic Variation
Heteroduplex Analysis
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Multivariate Analysis
Odds Ratio
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Periodontitis - microbiology
Polymerase Chain Reaction
Porphyromonas gingivalis
Porphyromonas gingivalis - genetics
Porphyromonas gingivalis - pathogenicity
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 23S - genetics
Virulence
Human
Porphyromonas gingivalis
Genetic variability
Genetic marker
Stomatology
Virulence
Ribosomal DNA
Spacer DNA
Bacteroidaceae
Infection
Periodontal disease
Periodontitis
Bacteriosis
Bacteria
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Abstract Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
AbstractList To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects with clear indicators of periodontitis and in a healthy, age-matched control group was examined. The presence of heteroduplex types of P. gingivalis in the two groups was determined with a PCR-based assay. This assay relied on detection of polymorphisms in the ribosomal internal spacer region (ISR). ISR fragments generated by PCR with P. gingivalis-specific primers were hybridized to fragments from reference strains, and the formation of heteroduplexes from the hybridization of nonidentical sequences was observed by polyacrylamide gel electrophoresis. Characteristic fingerprints from comparison with a panel of reference strains allowed the identification of heteroduplex types in clinical samples. One hundred thirty adults with periodontitis and 181 controls were sampled. With this approach, 11 heteroduplex types of P. gingivalis were detected in the population. Sufficient numbers were available for statistical analysis of six of these types. Heteroduplex type hW83 was found to be very strongly associated with periodontitis (P = 0.0000), and two additional types, h49417 and hHG1691, were also significantly associated with disease. The remaining types, h23A4, h381, and hA7A1, were detected more frequently in subjects with periodontitis than in healthy subjects, but the difference was not significant. These data indicate that virulence in human periodontitis varies among strains of P. gingivalis, and they identify an apparently highly virulent subgroup.
To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects with clear indicators of periodontitis and in a healthy, age-matched control group was examined. The presence of heteroduplex types of P. gingivalis in the two groups was determined with a PCR-based assay. This assay relied on detection of polymorphisms in the ribosomal internal spacer region (ISR). ISR fragments generated by PCR with P. gingivalis -specific primers were hybridized to fragments from reference strains, and the formation of heteroduplexes from the hybridization of nonidentical sequences was observed by polyacrylamide gel electrophoresis. Characteristic fingerprints from comparison with a panel of reference strains allowed the identification of heteroduplex types in clinical samples. One hundred thirty adults with periodontitis and 181 controls were sampled. With this approach, 11 heteroduplex types of P. gingivalis were detected in the population. Sufficient numbers were available for statistical analysis of six of these types. Heteroduplex type hW83 was found to be very strongly associated with periodontitis ( P = 0.0000), and two additional types, h49417 and hHG1691, were also significantly associated with disease. The remaining types, h23A4, h381, and hA7A1, were detected more frequently in subjects with periodontitis than in healthy subjects, but the difference was not significant. These data indicate that virulence in human periodontitis varies among strains of P. gingivalis , and they identify an apparently highly virulent subgroup.
To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects with clear indicators of periodontitis and in a healthy, age-matched control group was examined. The presence of heteroduplex types of P. gingivalis in the two groups was determined with a PCR-based assay. This assay relied on detection of polymorphisms in the ribosomal internal spacer region (ISR). ISR fragments generated by PCR with P. gingivalis-specific primers were hybridized to fragments from reference strains, and the formation of heteroduplexes from the hybridization of nonidentical sequences was observed by polyacrylamide gel electrophoresis. Characteristic fingerprints from comparison with a panel of reference strains allowed the identification of heteroduplex types in clinical samples. One hundred thirty adults with periodontitis and 181 controls were sampled. With this approach, 11 heteroduplex types of P. gingivalis were detected in the population. Sufficient numbers were available for statistical analysis of six of these types. Heteroduplex type hW83 was found to be very strongly associated with periodontitis (P = 0.0000), and two additional types, h49417 and hHG1691, were also significantly associated with disease. The remaining types, h23A4, h381, and hA7A1, were detected more frequently in subjects with periodontitis than in healthy subjects, but the difference was not significant. These data indicate that virulence in human periodontitis varies among strains of P. gingivalis, and they identify an apparently highly virulent subgroup.To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects with clear indicators of periodontitis and in a healthy, age-matched control group was examined. The presence of heteroduplex types of P. gingivalis in the two groups was determined with a PCR-based assay. This assay relied on detection of polymorphisms in the ribosomal internal spacer region (ISR). ISR fragments generated by PCR with P. gingivalis-specific primers were hybridized to fragments from reference strains, and the formation of heteroduplexes from the hybridization of nonidentical sequences was observed by polyacrylamide gel electrophoresis. Characteristic fingerprints from comparison with a panel of reference strains allowed the identification of heteroduplex types in clinical samples. One hundred thirty adults with periodontitis and 181 controls were sampled. With this approach, 11 heteroduplex types of P. gingivalis were detected in the population. Sufficient numbers were available for statistical analysis of six of these types. Heteroduplex type hW83 was found to be very strongly associated with periodontitis (P = 0.0000), and two additional types, h49417 and hHG1691, were also significantly associated with disease. The remaining types, h23A4, h381, and hA7A1, were detected more frequently in subjects with periodontitis than in healthy subjects, but the difference was not significant. These data indicate that virulence in human periodontitis varies among strains of P. gingivalis, and they identify an apparently highly virulent subgroup.
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Author Sharon R. Lyons
Eugene J. Leys
Ann L. Griffen
Mitzi R. Becker
Melvin L. Moeschberger
AuthorAffiliation Departments of Pediatric Dentistry 1 and Oral Biology, 2 College of Dentistry, 3 and Division of Epidemiology and Biometrics, School of Public Health, College of Medicine, 4 The Ohio State University, Columbus, Ohio
AuthorAffiliation_xml – name: Departments of Pediatric Dentistry 1 and Oral Biology, 2 College of Dentistry, 3 and Division of Epidemiology and Biometrics, School of Public Health, College of Medicine, 4 The Ohio State University, Columbus, Ohio
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  givenname: Sharon R.
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  fullname: Lyons, Sharon R.
  organization: <!--label omitted: 2-->Oral Biology,2
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  surname: Becker
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  surname: Moeschberger
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Issue 12
Keywords Human
Porphyromonas gingivalis
Genetic variability
Genetic marker
Stomatology
Virulence
Ribosomal DNA
Spacer DNA
Bacteroidaceae
Infection
Periodontal disease
Periodontitis
Bacteriosis
Bacteria
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Corresponding author. Mailing address: Department of Pediatric Dentistry, College of Dentistry, The Ohio State University, 305 W. 12th Ave., Columbus, OH 43210. Phone: (614) 292-1150. Fax: (614) 688-3077. E-mail: griffen.1@osu.edu.
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To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects...
To determine if there is variability in virulence among strains of Porphyromonas gingivalis in human periodontitis, their distribution in a group of subjects...
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SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4028
SubjectTerms Adult
Bacterial diseases
Bacteriology
Bacteroidaceae Infections - microbiology
Biological and medical sciences
DNA, Bacterial - genetics
DNA, Ribosomal - genetics
Ent and stomatologic bacterial diseases
Fundamental and applied biological sciences. Psychology
Genetic Variation
Heteroduplex Analysis
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Multivariate Analysis
Odds Ratio
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Periodontitis - microbiology
Polymerase Chain Reaction
Porphyromonas gingivalis
Porphyromonas gingivalis - genetics
Porphyromonas gingivalis - pathogenicity
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 23S - genetics
Virulence
Title Porphyromonas gingivalis Strain Variability and Periodontitis
URI http://jcm.asm.org/content/37/12/4028.abstract
https://www.ncbi.nlm.nih.gov/pubmed/10565925
https://www.proquest.com/docview/17354117
https://www.proquest.com/docview/69286331
https://pubmed.ncbi.nlm.nih.gov/PMC85871
Volume 37
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