Thyroid Hormone and Neural Stem Cells: Repair Potential Following Brain and Spinal Cord Injury

• Published in: Frontiers in neuroscience Vol. 14; p. 875
• Main Authors: Vancamp, Pieter, Butruille, Lucile, Demeneix, Barbara A., Remaud, Sylvie
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 26.08.2020; Frontiers; Frontiers Media S.A
• Subjects: Aging; Alzheimer's disease; Animal cognition; brain and spinal cord injury; Brain injury; Cell Behavior; Cell cycle; Cellular Biology; Development Biology; Ecology, environment; Embryology and Organogenesis; endogenous repair; Glial cells; Glial stem cells; Health; Hormones; Life Sciences; Mammals; Metabolism; Multiple sclerosis; Myelination; Neural networks; Neural stem cells; neurodegenerative disease; Neurodegenerative diseases; Neurogenesis; Neuronal-glial interactions; Neuroscience; Older people; Population; Spinal cord; Spinal cord injuries; Stem cells; Subventricular zone; Thyroid; Thyroid gland; thyroid hormone
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2020.00875

Neurodegenerative diseases are characterized by chronic neuronal and/or glial cell loss, while traumatic injury is often accompanied by the acute loss of both. Multipotent neural stem cells (NSCs) in the adult mammalian brain spontaneously proliferate, forming neuronal and glial progenitors that mig...