Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients - Wood, Lisa G.; Li, Qian; Scott, Hayley A.; Rutting, Sandra; Berthon, Bronwyn S.; Gibson, Peter G.; Hansbro, Philip M.; Williams, Evan; Horvat, Jay; Simpson, Jodie L.; Young, Paul; Oliver, Brian G.; et al. (Journal of allergy and clinical immunology, 2019)
Keywords: Adult; Aged; airway inflammation; Ambulatory care; Asthma; Asthma - diet therapy; Asthma - immunology; Asthma - pathology; Blood; Body mass index; Body weight loss; Carbohydrates; Cell Line; Cross-Sectional Studies; Cytokines; Dietary intake; Enzyme-linked immunosorbent assay; Fatty acids; Fatty Acids - administration & dosage; Female; Gene expression; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Growth factors; Humans; IL-1β; inflammasome; Inflammasomes; Inflammasomes - immunology; Inflammation; Interleukin-1beta - immunology; Kinases; Leukocyte Count; Leukocytes (neutrophilic); Lipopolysaccharides; Male; Meals; Middle Aged; Monocytes; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Nod1 protein; Nod1 Signaling Adaptor Protein - immunology; Obesity; Obesity - diet therapy; Obesity - immunology; Obesity - pathology; Oligomerization; Palmitic acid; Peripheral blood; Polyunsaturated fatty acids; Proteins; Respiratory tract; Respiratory tract diseases; saturated fat; Sputum; Sputum - immunology; Therapeutic applications; TLR4 protein; Toll-Like Receptor 4 - immunology; Toll-like receptors; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-α; Australia; airway inflammation; NOD; PUFA; saturated fat; asthma; IL-1β; IL-1R; Fatty acids; SFA; NF-κB; IL-1RAP; NLR; inflammasome; NLRP3; FA; TLR; obesity; BMI