Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder

• Published in: Brain, behavior, and immunity Vol. 93; pp. 214 - 225
• Main Authors: Burrows, Kaiping, Stewart, Jennifer L., Kuplicki, Rayus, Figueroa-Hall, Leandra, Spechler, Philip A., Zheng, Haixia, Guinjoan, Salvador M., Savitz, Jonathan B., Kent Teague, T., Paulus, Martin P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2021
• Subjects: C-reactive protein; Corpus Striatum; Depressive Disorder, Major; fMRI; Humans; Inflammation; Magnetic Resonance Imaging; Major depressive disorder; Motivation; Reward; Soluble intercellular adhesion molecule 1; Striatal reward; Soluble intercellular adhesion molecule 1; fMRI; Striatal reward; Inflammation; C-reactive protein; Major depressive disorder
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2021.01.016

•MDD-High exhibited lower striatal reward anticipation than MDD-Low.•MDD-High had higher sICAM-1 and IL-6 concentrations than MDD-Low and HC.•Within MDD-High, higher sICAM-1 levels were associated with lower striatal reward anticipation.•MDD exhibited lower precuneus response to large wins than HC.•...