Effects of the CYP2D610 allele on the pharmacokinetics of atomoxetine and its metabolites

• Published in: Archives of pharmacal research Vol. 38; no. 11; pp. 2083 - 2091
• Main Authors: Byeon, Ji-Yeong, Kim, Young-Hoon, Na, Han-Sung, Jang, Jong-Hwa, Kim, Se-Hyung, Lee, Yun-Jeong, Bae, Jung-Woo, Kim, In Su, Jang, Choon-Gon, Chung, Myeon-Woo, Lee, Seok-Yong
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.11.2015; 대한약학회
• Subjects: Adrenergic Uptake Inhibitors - pharmacokinetics; Adult; Alleles; Area Under Curve; Atomoxetine Hydrochloride - pharmacokinetics; Chromatography, Liquid; Cytochrome P-450 CYP2D6 - genetics; Genotype; Half-Life; Humans; Male; Medicine; metabolites; pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Phenols - pharmacokinetics; Phenyl Ethers - pharmacokinetics; Propylamines - pharmacokinetics; Research Article; risk; Tandem Mass Spectrometry; Young Adult; 약학; Atomoxetine; 4-hydroxyatomoxetine; Pharmacokinetics; CYP2D610

To investigate the effect of the variant CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites, 4-hydroxyatomoxetine (4-HAT) and N-desmethylatomoxetine (NAT), in healthy subjects, a single oral dose of atomoxetine was administered to 62 subjects with a CYP2D6*wt/*wt (*wt = *1 o...