A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory

• Published in: Progress in neurobiology Vol. 84; no. 2; pp. 105 - 115
• Main Author: Yamashima, Tetsumori
• Format: Journal Article
• Language: English
• Published: England 01.02.2008
• Subjects: Animals; Cell Differentiation; Fatty Acids, Unsaturated - metabolism; Haplorhini; Hippocampus - cytology; Hippocampus - physiology; Humans; Macaca; Memory - physiology; Neurons - cytology; Neurons - physiology; Receptors, G-Protein-Coupled - metabolism; Stem Cells - cytology; Stem Cells - physiology

Long chain polyunsaturated fatty acids (PUFA) such as docosahexaenoic and arachidonic acids, which are enriched in the brain, are important for multiple aspects of neuronal development and function including neurite outgrowth, signal transduction and membrane fluidity. Recent studies show that PUFA...