Reflex effects of independent stimulation of coronary and left ventricular mechanoreceptors in anaesthetised dogs
Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary...
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Published in | The Journal of physiology Vol. 528; no. 2; pp. 349 - 358 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
The Physiological Society
15.10.2000
Blackwell Science Ltd Blackwell Science Inc |
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Abstract | Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses
can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook
this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli
to each region were effectively separated.
Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow
separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by
varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by
changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors
were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses.
Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35 ± 1.9 and 40 ± 2.5 %, respectively.
Intracoronary injections of veratridine (30â60 μg) decreased vascular resistance by 31 ± 2.5 %. However, large increases in
ventricular pressure decreased resistance by only 9 ± 2.2 %.
Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg.
However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response.
These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular
receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial
ischaemia. |
---|---|
AbstractList | Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated. Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses. Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35+/-1.9 and 40+/-2.5%, respectively. Intracoronary injections of veratridine (30-60 microg) decreased vascular resistance by 31+/-2.5%. However, large increases in ventricular pressure decreased resistance by only 9+/-2.2%. Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response. These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia. 1 Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated. 2 Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses. 3 Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35 ± 1.9 and 40 ± 2.5 %, respectively. Intracoronary injections of veratridine (30–60 μg) decreased vascular resistance by 31 ± 2.5 %. However, large increases in ventricular pressure decreased resistance by only 9 ± 2.2 %. 4 Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end‐diastolic) before there was a significant response. 5 These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia. Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated. Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses. Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35 ± 1.9 and 40 ± 2.5 %, respectively. Intracoronary injections of veratridine (30–60 μg) decreased vascular resistance by 31 ± 2.5 %. However, large increases in ventricular pressure decreased resistance by only 9 ± 2.2 %. Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response. These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia. Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated. Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses. Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35 ± 1.9 and 40 ± 2.5 %, respectively. Intracoronary injections of veratridine (30â60 μg) decreased vascular resistance by 31 ± 2.5 %. However, large increases in ventricular pressure decreased resistance by only 9 ± 2.2 %. Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response. These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia. |
Author | C Wright R Hainsworth M J Drinkhill |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11034624$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1161/01.RES.8.3.530 10.1113/jphysiol.1993.sp019972 10.1172/JCI104284 10.1146/annurev.ph.42.030180.002213 10.1161/01.RES.41.5.694 10.1113/expphysiol.1987.sp003074 10.1152/physrev.1991.71.3.617 10.1113/expphysiol.1986.sp003018 10.1113/expphysiol.1996.sp003944 10.1113/jphysiol.1964.sp007490 10.1111/j.1748-1716.1948.tb00524.x 10.1161/01.RES.46.4.476 10.1161/01.RES.40.4.415 10.1113/jphysiol.1927.sp002363 10.1113/jphysiol.1912.sp001511 10.1016/0165-1838(91)90106-D 10.1113/jphysiol.1966.sp007950 10.1152/ajplegacy.1959.196.4.726 10.1113/jphysiol.1993.sp019973 10.1152/ajplegacy.1974.227.3.719 10.1172/JCI107281 10.1093/cvr/11.5.419 |
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VII. Receptor areas in the coronary arteries and elsewhere as revealed by the use of veratridine publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Dawes G. S. – volume: 254 start-page: R212 year: 1988 ident: e_1_2_5_14_1 article-title: Dynamic changes in venous outflow by baroreflex and left ventricular distension publication-title: American Journal of Physiology contributor: fullname: Hoka S. – ident: e_1_2_5_3_1 doi: 10.1113/jphysiol.1966.sp007950 – volume: 196 start-page: 726 issue: 4 year: 1959 ident: e_1_2_5_2_1 article-title: Cardiovascular and respiratory reflexes from the left side of the heart publication-title: American Journal of Physiology doi: 10.1152/ajplegacy.1959.196.4.726 contributor: fullname: Aviado D. M. – ident: e_1_2_5_10_1 doi: 10.1113/jphysiol.1993.sp019973 – volume: 227 start-page: 719 issue: 3 year: 1974 ident: e_1_2_5_5_1 article-title: Hemodynamic changes from stimulation of left ventricular baroreceptors publication-title: American Journal of Physiology doi: 10.1152/ajplegacy.1974.227.3.719 contributor: fullname: Chevalier P. A. – ident: e_1_2_5_20_1 doi: 10.1172/JCI107281 – ident: e_1_2_5_28_1 doi: 10.1093/cvr/11.5.419 |
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Snippet | Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses
can be criticised because of... 1 Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of... Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of... |
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SubjectTerms | Anesthesia Animals Blood Pressure - physiology Carotid Arteries - physiology Coronary Vessels - physiology Dogs Female Heart - physiology Male Mechanoreceptors - physiology Original Pressoreceptors - physiology Reflex - physiology Vascular Resistance - physiology Ventricular Function |
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Title | Reflex effects of independent stimulation of coronary and left ventricular mechanoreceptors in anaesthetised dogs |
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