Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity

• Published in: Journal of cellular and molecular medicine Vol. 15; no. 1; pp. 134 - 140
• Main Authors: Li, Jun, Xu, Jiahong, Xiao, Junjie, Zhang, Hong, Liang, Dandan, Liu, Yi, Zhang, Yangyang, Liu, Ying, Wen, Wei, Hu, Yaer, Yu, Zhuo, Yan, Biao, Jiang, Bing, Zhou, Zhao‐Nian, Chen, Yi‐Han
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2011; John Wiley & Sons, Inc
• Subjects: Animals; Anti-Arrhythmia Agents - pharmacology; Antiarrhythmics; Arrhythmias, Cardiac - drug therapy; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - pathology; Blotting, Western; Calcium - metabolism; Cardiac arrhythmia; Cardiovascular disease; Carrier Proteins - metabolism; Chronic Disease; Disease Models, Animal; Experiments; Heart; Homeostasis; Hypoxia; Hypoxia - metabolism; Ischemia; Ischemia - pathology; Ischemia - prevention & control; Laboratory animals; Male; Metabolic rate; Mitochondria; Mitochondria - metabolism; Preservation; Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Software; ventricular fibrillation; United States > US

Abnormal activation of mitochondrial translocator protein (TSPO) contributes to arrhythmogenesis during cardiac metabolic compromise; however, its role in the antiarrhythmic activities of chronic hypoxia adaptation remains unclear. Our results demonstrated that 80% of normoxic rats developed ischaem...