Deciphering the molecular mechanism of FLT3 resistance mutations - Georgoulia, Panagiota S.; Bjelic, Sinisa; Friedman, Ran (The FEBS journal, 2020)
Keywords: Acute myeloid leukemia; Aminopyridines - pharmacology; Benzothiazoles - pharmacology; Biochemistry; Biokemi; Catalytic activity; Clinical trials; Computer simulation; computers; Drug development; Drug resistance; Drug Resistance, Neoplasm - genetics; drugs; Enzyme kinetics; FLT3; fms-Like Tyrosine Kinase 3 - chemistry; fms-Like Tyrosine Kinase 3 - genetics; fms-Like Tyrosine Kinase 3 - metabolism; Humans; Inhibitors; kinase inhibitors; Kinases; Kinetics; leukaemia; Leukemia; Mathematical models; Molecular Biology; molecular dynamics; Molekylärbiologi; Mutation; myeloid leukemia; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Perturbation; Phenylurea Compounds - pharmacology; Protein Conformation; Protein Kinase Inhibitors - pharmacology; Protein structure; Protein-tyrosine kinase; Proteins; Pyrroles - pharmacology; Reaction kinetics; Resistant mutant; Tyrosine; leukaemia; kinase inhibitors; molecular dynamics; FLT3; enzyme kinetics