Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene‐3β, 17β‐diol

• Published in: Cancer science Vol. 102; no. 10; pp. 1848 - 1854
• Main Authors: Honma, Naoko, Saji, Shigehira, Hirose, Makiko, Horiguchi, Shin‐ichiro, Kuroi, Katsumasa, Hayashi, Shin‐ichi, Utsumi, Toshiaki, Harada, Nobuhiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011; Blackwell
• Subjects: Adult; Androstenediol - metabolism; Androstenedione - biosynthesis; Androstenedione - blood; Biological and medical sciences; Breast Neoplasms - blood; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Proliferation; Dehydroepiandrosterone - biosynthesis; Dehydroepiandrosterone - blood; Estradiol - biosynthesis; Estradiol - blood; Estrogen Receptor alpha - metabolism; Estrone - biosynthesis; Estrone - blood; Female; Gonadal Steroid Hormones - blood; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Postmenopause; Premenopause; Tumors; Human; Mammary gland diseases; Diol; Breast disease; Cancerology; Breast tumor; Serum; Breast cancer; Malignant tumor; Sex steroid hormone; Cancer

Estrogens play an important role in the pathobiology of breast cancer. In postmenopausal women, peripheral synthesis of estrogens from adrenal/ovarian androgens, dehydroepiandrosterone (DHEA) or androstenedione (Adione), by estrogen‐metabolizing enzymes is important. Besides estrone (E1) and estradi...