Region-specific dysregulation of glycogen synthase kinase-3β and β-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia

• Published in: Bipolar disorders Vol. 17; no. 2; pp. 160 - 171
• Main Authors: Pandey, Ghanshyam N, Rizavi, Hooriyah S, Tripathi, Madhulika, Ren, Xinguo
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.03.2015
• Subjects: Adult; Aged; Aged, 80 and over; Base Sequence; beta Catenin - genetics; beta Catenin - metabolism; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; bipolar illness; Brain - metabolism; Case-Control Studies; cingulate gyrus; Female; Glycogen Synthase Kinase 3 - genetics; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; GSK-3β; Gyrus Cinguli - metabolism; Humans; Male; Middle Aged; Molecular Sequence Data; pGSK-3β-ser-9; Phosphoproteins - metabolism; Phosphorylation; postmortem brain; prefrontal cortex; Prefrontal Cortex - metabolism; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Serine - metabolism; Signal Transduction; temporal cortex; Temporal Lobe - metabolism; Wnt Signaling Pathway; β-catenin; GSK-3β; β-catenin; pGSK-3β-ser-9; prefrontal cortex; postmortem brain; bipolar illness; schizophrenia; temporal cortex; cingulate gyrus

Objectives There is both direct and indirect evidence suggesting abnormalities of glycogen synthase kinase (GSK)‐3β and β‐catenin, two important components of the Wingless‐type (Wnt) signaling pathway, in the pathophysiology of bipolar illness and possibly schizophrenia (SZ). In order to further cla...