Wild immunology assessed by multidimensional mass cytometry

• Published in: Cytometry. Part A Vol. 91; no. 1; pp. 85 - 95
• Main Authors: Japp, Alberto Sada, Hoffmann, Kerstin, Schlickeiser, Stephan, Glauben, Rainer, Nikolaou, Christos, Maecker, Holden T., Braun, Julian, Matzmohr, Nadine, Sawitzki, Birgit, Siegmund, Britta, Radbruch, Andreas, Volk, Hans‐Dieter, Frentsch, Marco, Kunkel, Desiree, Thiel, Andreas
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017
• Subjects: adaptive immune system; Animals; Cluster analysis; Cytokines; Cytometry; Environmental conditions; Humans; Image Cytometry - methods; Immune system; Immunology; Inbreeding; innate immune system; Key terms: wild immunology; Killer Cells, Natural - immunology; Laboratories; Leukocytes - immunology; Lymphocytes B; Lymphocytes T; mass cytometry; Mice; Mice, Inbred Strains - immunology; Pathogens; Physiology; Priming; Signatures; Studies; T-Lymphocyte Subsets - immunology; adaptive immune system; mass cytometry; Key terms: wild immunology; innate immune system

A great part of our knowledge on mammalian immunology has been established in laboratory settings. The use of inbred mouse strains enabled controlled studies of immune cell and molecule functions in defined settings. These studies were usually performed in specific‐pathogen free (SPF) environments p...