real-time PCR assay to identify and discriminate among wild-type and vaccine strains of varicella-zoster virus and herpes simplex virus in clinical specimens, and comparison with the clinical diagnoses

A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-...

Full description

Saved in:
Bibliographic Details
Published inJournal of medical virology Vol. 81; no. 7; pp. 1310 - 1322
Main Authors Harbecke, Ruth, Oxman, Michael N, Arnold, Beth A, Ip, Charlotte, Johnson, Gary R, Levin, Myron J, Gelb, Lawrence D, Schmader, Kenneth E, Straus, Stephen E, Wang, Hui, Wright, Peter F, Pachucki, Constance T, Gershon, Anne A, Arbeit, Robert D, Davis, Larry E, Simberkoff, Michael S, Weinberg, Adriana, Williams, Heather M, Cheney, Carol, Petrukhin, Luba, Abraham, Katalin G, Shaw, Alan, Manoff, Susan, Antonello, Joseph M, Green, Tina, Wang, Yue, Tan, Charles, Keller, Paul M
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2009
Wiley
Subjects
beta-Globins - genetics
Biological and medical sciences
Chickenpox Vaccine
clinical trial
diagnosis of herpes zoster
Diagnosis, Differential
DNA Primers
Fundamental and applied biological sciences. Psychology
Herpes Simplex - diagnosis
Herpes Simplex Virus Vaccines
Herpes Zoster - diagnosis
Herpesvirus 3, Human - classification
Herpesvirus 3, Human - genetics
Herpesvirus 3, Human - isolation & purification
Human viral diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - standards
Polymorphism, Single Nucleotide
Reference Standards
Sensitivity and Specificity
Shingles Prevention Study
Simplexvirus - classification
Simplexvirus - genetics
Simplexvirus - isolation & purification
Techniques used in virology
Vaccines
Viral diseases
Virology
VZV ORF 62
zoster vaccine
Skin disease
Alphaherpesvirinae
Identification
Prevention
Shingles Prevention Study
zoster vaccine
Clinical trial
Herpesvirus hominis
Diagnosis
Clinical isolate
VZV ORF 62
Human
Varicella zoster virus
diagnosis of herpes zoster
Nervous system diseases
Herpes zoster
Vaccine strain
Herpesviridae
Vaccine
Method
Real time
Open reading frame
Infection
Virus
Polymerase chain reaction
Viral disease
Comparative study
Online AccessGet full text

Cover

Abstract A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human β-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results. J. Med. Virol. 81:1310-1322, 2009. Published 2009 Wiley-Liss, Inc.
AbstractList A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human β-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results.
A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human β-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results. J. Med. Virol. 81:1310-1322, 2009. Published 2009 Wiley-Liss, Inc.
A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human beta-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results.A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human beta-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results.
A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with suspected herpes zoster (HZ; shingles). Three sets of primers and probes were used in separate PCR reactions to detect and discriminate among wild-type VZV (VZV-WT), Oka vaccine strain VZV (VZV-Oka), and HSV DNA, and the reaction for each virus DNA was multiplexed with primers and probe specific for the human beta-globin gene to assess specimen adequacy. Discrimination of all VZV-WT strains, including Japanese isolates and the Oka parent strain, from VZV-Oka was based upon a single nucleotide polymorphism at position 106262 in ORF 62, resulting in preferential amplification by the homologous primer pair. The assay was highly sensitive and specific for the target virus DNA, and no cross-reactions were detected with any other infectious agent. With the PCR assay as the gold standard, the sensitivity of virus culture was 53% for VZV and 77% for HSV. There was 92% agreement between the clinical diagnosis of HZ by the Clinical Evaluation Committee and the PCR assay results.
Author Johnson, Gary R.
Arbeit, Robert D.
Simberkoff, Michael S.
Cheney, Carol
Oxman, Michael N.
Keller, Paul M.
Levin, Myron J.
Arnold, Beth A.
Ip, Charlotte
Pachucki, Constance T.
Gelb, Lawrence D.
Manoff, Susan
Weinberg, Adriana
Gershon, Anne A.
Harbecke, Ruth
Williams, Heather M.
Tan, Charles
Wang, Hui
Davis, Larry E.
Schmader, Kenneth E.
Abraham, Katalin G.
Wright, Peter F.
Wang, Yue
Petrukhin, Luba
Straus, Stephen E.
Green, Tina
Shaw, Alan
Antonello, Joseph M.
AuthorAffiliation 17 Department of Vaccine Biometrics Research, Merck Research Laboratories, West Point, Pennsylvania
8 Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland
2 Departments of Medicine and Pathology, University of California at San Diego, La Jolla, California
12 Division of Infectious Disease, Department of Medicine, Tufts Medical School, Boston, Massachusetts
14 VA New York Harbor Healthcare System and the Department of Medicine, New York University School of Medicine, New York, New York
11 Columbia University, New York, New York
4 VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, Connecticut
1 Department of Veterans Affairs (VA) San Diego Healthcare System, San Diego, California
5 Section of Pediatric Infectious Diseases, University of Colorado Denver, Aurora, Colorado
7 Department of Medicine, GRECC, Durham VA Medical Center, Duke University Medical Cente
AuthorAffiliation_xml – name: 17 Department of Vaccine Biometrics Research, Merck Research Laboratories, West Point, Pennsylvania
– name: 4 VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, Connecticut
– name: 8 Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland
– name: 7 Department of Medicine, GRECC, Durham VA Medical Center, Duke University Medical Center, Durham, North Carolina
– name: 12 Division of Infectious Disease, Department of Medicine, Tufts Medical School, Boston, Massachusetts
– name: 15 Departments of Pediatrics, Medicine and Pathology, University of Colorado Denver, Aurora, Colorado
– name: 3 Department of Vaccine and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania
– name: 13 New Mexico VA Healthcare System, Albuquerque, New Mexico
– name: 6 Department of Medicine, St. Louis VA Medical Center, Washington University, St. Louis, Missouri
– name: 10 Edward Hines Jr. VA Hospital, Chicago, Illinois
– name: 14 VA New York Harbor Healthcare System and the Department of Medicine, New York University School of Medicine, New York, New York
– name: 1 Department of Veterans Affairs (VA) San Diego Healthcare System, San Diego, California
– name: 11 Columbia University, New York, New York
– name: 16 Department of Infectious Disease and Vaccines, Merck Research Laboratories, West Point, Pennsylvania
– name: 9 Vanderbilt University Medical Center, Nashville, Tennessee
– name: 2 Departments of Medicine and Pathology, University of California at San Diego, La Jolla, California
– name: 5 Section of Pediatric Infectious Diseases, University of Colorado Denver, Aurora, Colorado
Author_xml – sequence: 1
  fullname: Harbecke, Ruth
– sequence: 2
  fullname: Oxman, Michael N
– sequence: 3
  fullname: Arnold, Beth A
– sequence: 4
  fullname: Ip, Charlotte
– sequence: 5
  fullname: Johnson, Gary R
– sequence: 6
  fullname: Levin, Myron J
– sequence: 7
  fullname: Gelb, Lawrence D
– sequence: 8
  fullname: Schmader, Kenneth E
– sequence: 9
  fullname: Straus, Stephen E
– sequence: 10
  fullname: Wang, Hui
– sequence: 11
  fullname: Wright, Peter F
– sequence: 12
  fullname: Pachucki, Constance T
– sequence: 13
  fullname: Gershon, Anne A
– sequence: 14
  fullname: Arbeit, Robert D
– sequence: 15
  fullname: Davis, Larry E
– sequence: 16
  fullname: Simberkoff, Michael S
– sequence: 17
  fullname: Weinberg, Adriana
– sequence: 18
  fullname: Williams, Heather M
– sequence: 19
  fullname: Cheney, Carol
– sequence: 20
  fullname: Petrukhin, Luba
– sequence: 21
  fullname: Abraham, Katalin G
– sequence: 22
  fullname: Shaw, Alan
– sequence: 23
  fullname: Manoff, Susan
– sequence: 24
  fullname: Antonello, Joseph M
– sequence: 25
  fullname: Green, Tina
– sequence: 26
  fullname: Wang, Yue
– sequence: 27
  fullname: Tan, Charles
– sequence: 28
  fullname: Keller, Paul M
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21539533$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/19475609$$D View this record in MEDLINE/PubMed
BookMark eNqFkl1v0zAYhSM0xLrBBX8AfAMSEtn8ETvNDRKqoDDGhwqDS-uN47QeiR3stKz8Q_4VTtuVD4G4ihQ_57yvj89RcmCd1Ulyl-ATgjE9vWxXJ5RwLG4kI4ILkRY4JwfJCJNMpEIQfpgchXCJMR4XlN5KDkmR5VzgYpR89xqatDetRu8mMwQhwBr1DplK297UawS2QpUJypvWWOg1gtbZOfpqmirt153eACtQyliNQu_B2IBcHX95o3TTQPrNhV57tDJ-GTb0QvtOBxRM2zX6andgLFKNsUZBg0KnVdzIhscbXrm2i27B2Ti2X6B-oX-ylYG5dUGH28nNGpqg7-y-x8nF82cfJi_S87fTl5On56nimIi0JByAMcAFy1WtxlXOoSQVLoXmVFSE0hpXnI_puC5ZVRcKsqzOiC651kSVwI6TJ1vfblm2ulIxJw-N7GJA4NfSgZG_n1izkHO3khklOcXjaPBwZ-Ddl6UOvWxjvkNUVrtlkCJnlFDM_gtmgmFasMHx3q8r7Xe5fuYIPNgBEGJotQerTNhzsTus4GyYeLrllHcheF1LZXrojRtuYhpJsBwKJ2Ph5KZwUfHoD8V--F_YnXssj17_G5Rnrz9eK9KtwsQKXe0V4D8PKeVcfnozla8yPj0Ts0zOIn9_y9fgJMxjZ-TFe4oJiy_PCsHH7Af7RwN8
CODEN JMVIDB
CitedBy_id crossref_primary_10_1093_cid_cir970
crossref_primary_10_1016_j_idc_2017_07_016
crossref_primary_10_1016_j_vaccine_2019_10_038
crossref_primary_10_1038_nrdp_2015_16
crossref_primary_10_3389_fmed_2022_850762
crossref_primary_10_1016_j_cger_2016_02_011
crossref_primary_10_1016_j_prro_2013_02_004
crossref_primary_10_1093_infdis_jit182
crossref_primary_10_1093_infdis_jiaa734
crossref_primary_10_1093_infdis_jit342
crossref_primary_10_1111_j_1600_0560_2012_01963_x
crossref_primary_10_4065_mcp_2010_0618
crossref_primary_10_1016_j_mayocp_2019_03_024
crossref_primary_10_17795_bhs_37062
crossref_primary_10_1097_SAP_0000000000001505
crossref_primary_10_1093_cid_ciu918
crossref_primary_10_7759_cureus_22062
crossref_primary_10_3390_nu12082384
crossref_primary_10_1007_s13365_018_0697_2
crossref_primary_10_1128_microbiolspec_DMIH2_0017_2015
crossref_primary_10_1016_S1386_6532_10_70004_4
crossref_primary_10_1159_000512956
crossref_primary_10_1128_jcm_02355_21
crossref_primary_10_1016_j_jcv_2014_09_012
crossref_primary_10_5811_cpcem_2019_8_43010
crossref_primary_10_1111_jdv_17646
crossref_primary_10_1016_j_vaccine_2015_04_090
crossref_primary_10_1093_cid_cis638
crossref_primary_10_1016_j_coviro_2011_07_007
crossref_primary_10_1017_S0950268817001509
crossref_primary_10_1016_j_diagmicrobio_2025_116765
crossref_primary_10_1128_CVI_05021_11
crossref_primary_10_1128_CVI_00095_12
crossref_primary_10_3390_bioengineering10050520
crossref_primary_10_1080_07853890_2023_2253733
crossref_primary_10_1249_JSR_0000000000001005
crossref_primary_10_1093_infdis_jit344
crossref_primary_10_1007_s00467_021_05200_x
crossref_primary_10_1007_s13730_021_00576_z
crossref_primary_10_1002_rmv_1789
crossref_primary_10_1016_j_clindermatol_2024_01_007
crossref_primary_10_1097_ICU_0b013e32833bb58c
crossref_primary_10_4103_IJO_IJO_2942_22
Cites_doi 10.1016/S0166-0934(03)00229-5
10.1128/JCM.42.4.1409-1413.2004
10.1086/514267
10.1056/NEJMoa051016
10.1016/S1386-6532(99)00042-6
10.1002/jmv.1890290108
10.1128/JCM.38.8.3116-3118.2000
10.1086/423210
10.1016/j.jcv.2007.07.007
10.1128/JCM.38.12.4315-4319.2000
10.1086/315335
10.1128/JCM.01175-06
10.1086/510532
10.1128/JCM.38.9.3156-3160.2000
10.1016/S1386-6532(02)00197-X
10.1128/CMR.19.1.165-256.2006
10.1002/1096-9071(200008)61:4<497::AID-JMV13>3.0.CO;2-2
10.1086/522140
10.1002/jmv.20253
10.1111/j.1468-3083.2008.02587.x
10.1002/jmv.1890090110
10.1016/S1386-6532(03)00112-4
10.1128/jcm.33.3.658-660.1995
10.1128/JVI.66.2.1016-1020.1992
ContentType Journal Article
Contributor Annunziato, Paula
Boardman, Kathy D
Yeh, S S
Keitel, W A
Oxman, Michael N
Hayward, Anthony R
Arbeit, Robert D
Loutit, J
Levin, M J
Davis, L E
Goodman, R P
Gelb, L D
Gelb, Lawrence D
Pachucki, C T
Guatelli, J
Brooks, P A
Beisel, Christopher E
Silber, Jeffrey L
Cotton, D J
Davis, Larry E
Peduzzi, Peter N
Barry, Patricia
Neuzil, K M
Chan, Ivan S F
Levin, Myron J
Crawford, G E
Arbeit, R D
Schmader, Kenneth E
Simberkoff, Michael S
Keay, S K
Schmader, K E
Gershon, Anne A
Weinberg, Adriana
Betts, R F
Marques, A R
Greenberg, R N
Kauffman, C A
Irwin, Michael R
Brunell, P
Griffin, M R
Morrison, V A
Serrao, R
Soto, N E
Straus, Stephen E
Toney, J F
Gnann, J W
Simberkoff, M S
Lobo, Z
Wright, P F
Chan, Christina Y
Colling, Cindy L
Williams, Heather M
Holodniy, M
Johnson, Gary R
Contributor_xml – sequence: 1
  givenname: Michael N
  surname: Oxman
  fullname: Oxman, Michael N
– sequence: 2
  givenname: Robert D
  surname: Arbeit
  fullname: Arbeit, Robert D
– sequence: 3
  givenname: Patricia
  surname: Barry
  fullname: Barry, Patricia
– sequence: 4
  givenname: Christopher E
  surname: Beisel
  fullname: Beisel, Christopher E
– sequence: 5
  givenname: Kathy D
  surname: Boardman
  fullname: Boardman, Kathy D
– sequence: 6
  givenname: Cindy L
  surname: Colling
  fullname: Colling, Cindy L
– sequence: 7
  givenname: Larry E
  surname: Davis
  fullname: Davis, Larry E
– sequence: 8
  givenname: Lawrence D
  surname: Gelb
  fullname: Gelb, Lawrence D
– sequence: 9
  givenname: Anne A
  surname: Gershon
  fullname: Gershon, Anne A
– sequence: 10
  givenname: Anthony R
  surname: Hayward
  fullname: Hayward, Anthony R
– sequence: 11
  givenname: Michael R
  surname: Irwin
  fullname: Irwin, Michael R
– sequence: 12
  givenname: Gary R
  surname: Johnson
  fullname: Johnson, Gary R
– sequence: 13
  givenname: Myron J
  surname: Levin
  fullname: Levin, Myron J
– sequence: 14
  givenname: Peter N
  surname: Peduzzi
  fullname: Peduzzi, Peter N
– sequence: 15
  givenname: Kenneth E
  surname: Schmader
  fullname: Schmader, Kenneth E
– sequence: 16
  givenname: Michael S
  surname: Simberkoff
  fullname: Simberkoff, Michael S
– sequence: 17
  givenname: Stephen E
  surname: Straus
  fullname: Straus, Stephen E
– sequence: 18
  givenname: Adriana
  surname: Weinberg
  fullname: Weinberg, Adriana
– sequence: 19
  givenname: Heather M
  surname: Williams
  fullname: Williams, Heather M
– sequence: 20
  givenname: Jeffrey L
  surname: Silber
  fullname: Silber, Jeffrey L
– sequence: 21
  givenname: Paula
  surname: Annunziato
  fullname: Annunziato, Paula
– sequence: 22
  givenname: Christina Y
  surname: Chan
  fullname: Chan, Christina Y
– sequence: 23
  givenname: Ivan S F
  surname: Chan
  fullname: Chan, Ivan S F
– sequence: 24
  givenname: L E
  surname: Davis
  fullname: Davis, L E
– sequence: 25
  givenname: C A
  surname: Kauffman
  fullname: Kauffman, C A
– sequence: 26
  givenname: S K
  surname: Keay
  fullname: Keay, S K
– sequence: 27
  givenname: A R
  surname: Marques
  fullname: Marques, A R
– sequence: 28
  givenname: N E
  surname: Soto
  fullname: Soto, N E
– sequence: 29
  givenname: P
  surname: Brunell
  fullname: Brunell, P
– sequence: 30
  givenname: J W
  surname: Gnann
  fullname: Gnann, J W
– sequence: 31
  givenname: R
  surname: Serrao
  fullname: Serrao, R
– sequence: 32
  givenname: D J
  surname: Cotton
  fullname: Cotton, D J
– sequence: 33
  givenname: R P
  surname: Goodman
  fullname: Goodman, R P
– sequence: 34
  givenname: R D
  surname: Arbeit
  fullname: Arbeit, R D
– sequence: 35
  givenname: C T
  surname: Pachucki
  fullname: Pachucki, C T
– sequence: 36
  givenname: M J
  surname: Levin
  fullname: Levin, M J
– sequence: 37
  givenname: K E
  surname: Schmader
  fullname: Schmader, K E
– sequence: 38
  givenname: W A
  surname: Keitel
  fullname: Keitel, W A
– sequence: 39
  givenname: R N
  surname: Greenberg
  fullname: Greenberg, R N
– sequence: 40
  givenname: V A
  surname: Morrison
  fullname: Morrison, V A
– sequence: 41
  givenname: P F
  surname: Wright
  fullname: Wright, P F
– sequence: 42
  givenname: M R
  surname: Griffin
  fullname: Griffin, M R
– sequence: 43
  givenname: M S
  surname: Simberkoff
  fullname: Simberkoff, M S
– sequence: 44
  givenname: S S
  surname: Yeh
  fullname: Yeh, S S
– sequence: 45
  givenname: Z
  surname: Lobo
  fullname: Lobo, Z
– sequence: 46
  givenname: M
  surname: Holodniy
  fullname: Holodniy, M
– sequence: 47
  givenname: J
  surname: Loutit
  fullname: Loutit, J
– sequence: 48
  givenname: R F
  surname: Betts
  fullname: Betts, R F
– sequence: 49
  givenname: L D
  surname: Gelb
  fullname: Gelb, L D
– sequence: 50
  givenname: G E
  surname: Crawford
  fullname: Crawford, G E
– sequence: 51
  givenname: J
  surname: Guatelli
  fullname: Guatelli, J
– sequence: 52
  givenname: P A
  surname: Brooks
  fullname: Brooks, P A
– sequence: 53
  givenname: K M
  surname: Neuzil
  fullname: Neuzil, K M
– sequence: 54
  givenname: J F
  surname: Toney
  fullname: Toney, J F
Copyright This article is a US Government work and, as such, is in the public domain in the United States of America. Published © 2009 Wiley‐Liss, Inc.
2009 INIST-CNRS
Published 2009 Wiley-Liss, Inc.
Copyright_xml – notice: This article is a US Government work and, as such, is in the public domain in the United States of America. Published © 2009 Wiley‐Liss, Inc.
– notice: 2009 INIST-CNRS
– notice: Published 2009 Wiley-Liss, Inc.
CorporateAuthor for the Shingles Prevention Study Group
Shingles Prevention Study Group
CorporateAuthor_xml – name: for the Shingles Prevention Study Group
– name: Shingles Prevention Study Group
DBID FBQ
BSCLL
AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7S9
L.6
7X8
5PM
DOI 10.1002/jmv.21506
DatabaseName AGRIS
Istex
CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
DatabaseTitleList
AGRICOLA
MEDLINE - Academic
CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1096-9071
EndPage 1322
ExternalDocumentID PMC4217208
19475609
21539533
10_1002_jmv_21506
JMV21506
ark_67375_WNG_K45GJ6R4_R
US201301639658
Genre article
Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Evaluation Study
Journal Article
GrantInformation_xml – fundername: Cooperative Studies Program, Department of Veterans Affairs, Office of Research and Development
– fundername: Merck (to the Cooperative Studies Program)
– fundername: James R. and Jesse V. Scott Fund for Shingles Research (to Dr. Oxman)
– fundername: Intramural NIH HHS
  grantid: Z01 AI000856
– fundername: NIAID NIH HHS
  grantid: P30 AI036214
GroupedDBID ---
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
1L6
1OB
1OC
1ZS
31~
33P
3O-
3SF
3WU
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5RE
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AAHQN
AAIPD
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABJNI
ABOCM
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFRAH
AFWVQ
AFZJQ
AGHNM
AHBTC
AHMBA
AI.
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBD
EBS
ECGQY
EJD
ELTNK
EMOBN
F00
F01
F04
F5P
FBQ
FEDTE
FUBAC
G-S
G.N
GNP
GODZA
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
HZ~
IX1
J0M
JPC
KBYEO
KQQ
L7B
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M65
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
RJQFR
ROL
RX1
RYL
SAMSI
SUPJJ
SV3
TEORI
TUS
UB1
V2E
VH1
W8V
W99
WBKPD
WHG
WIB
WIH
WIJ
WIK
WJL
WNSPC
WOHZO
WQJ
WXI
WXSBR
WYISQ
X7M
XG1
XPP
XV2
ZGI
ZXP
ZZTAW
~IA
~KM
~WT
AEUQT
AFPWT
BSCLL
RGB
RWI
WRC
WUP
AAYXX
AEYWJ
AGQPQ
AGYGG
CITATION
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7S9
L.6
7X8
5PM
ID FETCH-LOGICAL-c5016-b15aa33a0937cfc8d75ab1d0b6e526d122f0d55828fb3df9ca44f41eb5ee1cba3
IEDL.DBID DR2
ISSN 0146-6615
1096-9071
IngestDate Thu Aug 21 18:10:45 EDT 2025
Thu Jul 10 22:25:43 EDT 2025
Fri Jul 11 14:38:55 EDT 2025
Mon Jul 21 05:31:32 EDT 2025
Mon Jul 21 09:17:22 EDT 2025
Thu Apr 24 22:59:08 EDT 2025
Tue Jul 01 02:24:22 EDT 2025
Wed Jan 22 16:21:08 EST 2025
Wed Oct 30 09:53:55 EDT 2024
Thu Apr 03 09:44:48 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords Skin disease
Alphaherpesvirinae
Identification
Prevention
Shingles Prevention Study
zoster vaccine
Clinical trial
Herpesvirus hominis
Diagnosis
Clinical isolate
VZV ORF 62
Human
Varicella zoster virus
diagnosis of herpes zoster
Nervous system diseases
Herpes zoster
Vaccine strain
Herpesviridae
Vaccine
Method
Real time
Open reading frame
Infection
Virus
Polymerase chain reaction
Viral disease
Comparative study
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
CC BY 4.0
Published 2009 Wiley-Liss, Inc.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5016-b15aa33a0937cfc8d75ab1d0b6e526d122f0d55828fb3df9ca44f41eb5ee1cba3
Notes http://dx.doi.org/10.1002/jmv.21506
ArticleID:JMV21506
James R. and Jesse V. Scott Fund for Shingles Research (to Dr. Oxman)
ark:/67375/WNG-K45GJ6R4-R
Merck (to the Cooperative Studies Program)
This article is a US Government work and, as such, is in the public domain in the United States of America.
Cooperative Studies Program, Department of Veterans Affairs, Office of Research and Development
istex:9F7A603E3B532D03294830F8313C6FF607943C9D
Study Investigators include
Deceased.
L.E. Davis (Albuquerque, NM); C.A. Kauffman (Ann Arbor, MI); S.K. Keay (Baltimore, MD); A.R. Marques, N.E. Soto, and P. Brunell (Bethesda, MD), J.W. Gnann (Birmingham, AL); R. Serrao, D.J. Cotton, R.P. Goodman, and R.D. Arbeit (Boston, MA); C.T. Pachucki (Hines, IL); M.J. Levin (Denver, CO); K.E. Schmader (Durham, NC); W.A. Keitel (Houston, TX); R.N. Greenberg (Lexington, KY); V.A. Morrison (Minneapolis, MN); P.F. Wright and M.R. Griffin (Nashville, TN); M.S. Simberkoff (New York, NY); S.S. Yeh and Z. Lobo (Northport, NY); M. Holodniy and J. Loutit (Palo Alto, CA); R.F. Betts (Rochester, NY); L.D. Gelb (St. Louis, MO); G.E. Crawford (San Antonio, TX); J. Guatelli and P.A. Brooks (San Diego, CA); K.M. Neuzil (Seattle, WA); and J.F. Toney (Tampa, FL).
The Shingles Prevention Study was planned and/or administered by a Planning/Executive committee consisting of Michael N. Oxman (Chair), Robert D. Arbeit, Patricia Barry, Christopher E. Beisel, Kathy D. Boardman, Cindy L. Colling, Larry E. Davis, Lawrence D. Gelb, Anne A. Gershon, Anthony R. Hayward, Michael R. Irwin, Gary R. Johnson, Myron J. Levin, Peter N. Peduzzi, Kenneth E. Schmader, Michael S. Simberkoff, Stephen E. Straus (deceased), Adriana Weinberg, Heather M. Williams, Jeffrey L. Silber, Paula Annunziato, Christina Y. Chan, and Ivan S.F. Chan.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Undefined-1
ObjectType-Feature-3
PMID 19475609
PQID 46302938
PQPubID 24069
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4217208
proquest_miscellaneous_67321203
proquest_miscellaneous_46302938
pubmed_primary_19475609
pascalfrancis_primary_21539533
crossref_citationtrail_10_1002_jmv_21506
crossref_primary_10_1002_jmv_21506
wiley_primary_10_1002_jmv_21506_JMV21506
istex_primary_ark_67375_WNG_K45GJ6R4_R
fao_agris_US201301639658
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate July 2009
PublicationDateYYYYMMDD 2009-07-01
PublicationDate_xml – month: 07
  year: 2009
  text: July 2009
PublicationDecade 2000
PublicationPlace Hoboken
PublicationPlace_xml – name: Hoboken
– name: Hoboken, NJ
– name: United States
PublicationTitle Journal of medical virology
PublicationTitleAlternate J. Med. Virol
PublicationYear 2009
Publisher Wiley Subscription Services, Inc., A Wiley Company
Wiley
Publisher_xml – name: Wiley Subscription Services, Inc., A Wiley Company
– name: Wiley
References Niesters HGM. 2002. Clinical virology in real-time. J Clin Virol 25: S3-S12.
Tang YW, Allawi HT, DeLeon-Carnes M, Li H, Day SP, Schmid DS. 2007. Detection and differentiation of wild-type and vaccine mutant varicella-zoster viruses using an Invader Plus method. J Clin Virol 40: 129-134.
Adams SG, Dohner DE, Gelb LD. 1989. Restriction fragment differences between the genomes of the Oka varicella vaccine virus and American wild-type varicella-zoster virus. J Med Virol 29: 38-45.
LaRussa P, Steinberg S, Arvin A, Dwyer D, Burgess M, Menegus M, Rekrut K, Yamanishi K, Gershon A. 1998. Polymerase chain reaction and restriction fragment length polymorphism analysis of varicella-zoster virus isolates from the United States and other parts of the world. J Infect Dis 178: S64-S66.
Quinlivan M, Gershon AA, Steinberg SP, Breuer J. 2005. An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virus. J Med Virol 75: 174-180.
Allawi HT, Li H, Sander T, Aslanukov A, Lyamichev VI, Blackman A, Elagin S, Tang YW. 2006. Invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2. J Clin Microbiol 44: 3443-3447.
Campsall PA, Au NHC, Prendiville JS, Speert DP, Tan R, Thomas EE. 2004. Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination real-time PCR. J Clin Microbiol 42: 1409-1413.
LaRussa P, Lungu O, Hardy I, Gershon A, Steinberg SP, Silverstein S. 1992. Restriction fragment length polymorphism of polymerase chain reaction products from vaccine and wild-type varicella-zoster virus isolates. J Virol 66: 1016-1020.
Martin JH, Dohner DE, Wellinghoff WJ, Gelb LD. 1982. Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs. J Med Virol 9: 69-76.
Quinlivan ML, Gershon AA, Steinberg SP, Breuer J. 2004. Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of virus. J Infect Dis 190: 793-796.
Espy MJ, Uhl JR, Sloan LM, Buckwalter SP, Jones MF, Vetter EA, Yao JDC, Wengenack NL, Rosenblatt JE, Cockerill FR III, Smith TF. 2006. Real-time PCR in clinical microbiology: Applications for routine laboratory testing. Clin Microbiol Rev 19: 165-256.
Espy MJ, Ross TK, Teo R, Svien KA, Wold AD, Uhl JR, Smith TF. 2000. Evaluation of LightCycler PCR for implementation of laboratory diagnosis of herpes simplex virus infections. J Clin Microbiol 38: 3116-3118.
Sauerbrei A, Eichorn U, Schacke M, Wutzler P. 1999. Laboratory diagnosis of herpes zoster. J Clin Virol 14: 31-36.
Argaw T, Cohen JI, Klutch M, Lekstrom K, Yoshikawa T, Asano Y, Krause PR. 2000. Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella-zoster virus isolates. J Infect Dis 181: 1153-1157.
Loparev VN, Argaw T, Krause PR, Takayama M, Schmid DS. 2000a. Improved identification and differentiation of varicella-zoster virus (VZV) wild-type strains and an attenuated varicella vaccine strain using a VZV open reading frame 62-based PCR. J Clin Microbiol 38: 3156-3160.
Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan ISF, Wang WWB, Annunziato PW, Silber JL. 2005a. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 352: 2271-2284.
Gomi Y, Imagawa T, Takahashi M, Yamanishi K. 2000. Oka varicella vaccine is distinguishable from its parental virus in DNA sequence of open reading frame 62 and its transactivation activity. J Med Virol 61: 497-503.
Breuer J, Schmid DS. 2008. Vaccine Oka variants and sequence variability in vaccine-related skin lesions. J Infect Dis 197: S54-S57.
Takayama M, Takayama N. 2004. New method of differentiating wild-type varicella-zoster virus (VZV) strains from Oka varicella vaccine strain by VZV ORF 6-based PCR and restriction fragment length polymorphism analysis. J Clin Virol 29: 113-119.
Takada M, Suzutani T, Yoshida I, Matoba M, Azuma M. 1995. Identification of varicella-zoster virus strains by PCR analysis of three repeat elements and a PstI-site-less region. J Clin Microbiol 33: 658-660.
Giehl KA, Müller-Sander E, Rottenkolber M, Degitz K, Volkenandt M, Berking C. 2008. Identification and characterization of 20 immunocompetent patients with simultaneous varicella zoster and herpes simplex virus infection. J Eur Acad Dermatol Venereol 22: 722-728.
Tipples GA, Safronetz D, Gray M. 2003. A real-time PCR assay for the detection of varicella-zoster virus DNA and differentiation of vaccine, wild-type and control strains. J Virol Meth 113: 113-116.
Loparev VN, Rubtcova E, Seward JF, Levin MJ, Schmid DS. 2007. DNA sequence variability in isolates recovered from patients with postvaccination rash or herpes zoster caused by Oka varicella vaccine. J Infect Dis 195: 502-510.
Loparev VN, McCaustland K, Holloway BP, Krause PR, Takayama M, Schmid DS. 2000b. Rapid genotyping of varicella-zoster virus vaccine and wild-type strains with fluorophore-labeled hybridization probes. J Clin Microbiol 38: 4315-4319.
2004; 42
2004; 29
2005a; 352
1995; 33
2000a; 38
2006; 19
2003; 113
1998; 178
1989; 29
2002; 25
2000b; 38
2000; 38
2005b
2007; 195
2004; 190
2006; 44
1999; 14
2000; 61
1982; 9
2005; 75
2008; 22
2007; 40
1992; 66
2008; 197
2000; 181
Takada M (e_1_2_1_23_1) 1995; 33
e_1_2_1_20_1
e_1_2_1_24_1
e_1_2_1_21_1
e_1_2_1_22_1
e_1_2_1_25_1
e_1_2_1_26_1
e_1_2_1_7_1
e_1_2_1_8_1
e_1_2_1_5_1
e_1_2_1_6_1
e_1_2_1_3_1
e_1_2_1_12_1
e_1_2_1_4_1
e_1_2_1_13_1
e_1_2_1_10_1
e_1_2_1_2_1
e_1_2_1_11_1
e_1_2_1_16_1
e_1_2_1_17_1
e_1_2_1_14_1
e_1_2_1_15_1
e_1_2_1_9_1
e_1_2_1_18_1
e_1_2_1_19_1
References_xml – reference: Breuer J, Schmid DS. 2008. Vaccine Oka variants and sequence variability in vaccine-related skin lesions. J Infect Dis 197: S54-S57.
– reference: Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan ISF, Wang WWB, Annunziato PW, Silber JL. 2005a. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 352: 2271-2284.
– reference: Argaw T, Cohen JI, Klutch M, Lekstrom K, Yoshikawa T, Asano Y, Krause PR. 2000. Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella-zoster virus isolates. J Infect Dis 181: 1153-1157.
– reference: Campsall PA, Au NHC, Prendiville JS, Speert DP, Tan R, Thomas EE. 2004. Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination real-time PCR. J Clin Microbiol 42: 1409-1413.
– reference: Loparev VN, Rubtcova E, Seward JF, Levin MJ, Schmid DS. 2007. DNA sequence variability in isolates recovered from patients with postvaccination rash or herpes zoster caused by Oka varicella vaccine. J Infect Dis 195: 502-510.
– reference: Quinlivan ML, Gershon AA, Steinberg SP, Breuer J. 2004. Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of virus. J Infect Dis 190: 793-796.
– reference: Espy MJ, Ross TK, Teo R, Svien KA, Wold AD, Uhl JR, Smith TF. 2000. Evaluation of LightCycler PCR for implementation of laboratory diagnosis of herpes simplex virus infections. J Clin Microbiol 38: 3116-3118.
– reference: Takayama M, Takayama N. 2004. New method of differentiating wild-type varicella-zoster virus (VZV) strains from Oka varicella vaccine strain by VZV ORF 6-based PCR and restriction fragment length polymorphism analysis. J Clin Virol 29: 113-119.
– reference: Allawi HT, Li H, Sander T, Aslanukov A, Lyamichev VI, Blackman A, Elagin S, Tang YW. 2006. Invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2. J Clin Microbiol 44: 3443-3447.
– reference: Niesters HGM. 2002. Clinical virology in real-time. J Clin Virol 25: S3-S12.
– reference: Takada M, Suzutani T, Yoshida I, Matoba M, Azuma M. 1995. Identification of varicella-zoster virus strains by PCR analysis of three repeat elements and a PstI-site-less region. J Clin Microbiol 33: 658-660.
– reference: Loparev VN, McCaustland K, Holloway BP, Krause PR, Takayama M, Schmid DS. 2000b. Rapid genotyping of varicella-zoster virus vaccine and wild-type strains with fluorophore-labeled hybridization probes. J Clin Microbiol 38: 4315-4319.
– reference: Sauerbrei A, Eichorn U, Schacke M, Wutzler P. 1999. Laboratory diagnosis of herpes zoster. J Clin Virol 14: 31-36.
– reference: Gomi Y, Imagawa T, Takahashi M, Yamanishi K. 2000. Oka varicella vaccine is distinguishable from its parental virus in DNA sequence of open reading frame 62 and its transactivation activity. J Med Virol 61: 497-503.
– reference: LaRussa P, Steinberg S, Arvin A, Dwyer D, Burgess M, Menegus M, Rekrut K, Yamanishi K, Gershon A. 1998. Polymerase chain reaction and restriction fragment length polymorphism analysis of varicella-zoster virus isolates from the United States and other parts of the world. J Infect Dis 178: S64-S66.
– reference: Espy MJ, Uhl JR, Sloan LM, Buckwalter SP, Jones MF, Vetter EA, Yao JDC, Wengenack NL, Rosenblatt JE, Cockerill FR III, Smith TF. 2006. Real-time PCR in clinical microbiology: Applications for routine laboratory testing. Clin Microbiol Rev 19: 165-256.
– reference: Loparev VN, Argaw T, Krause PR, Takayama M, Schmid DS. 2000a. Improved identification and differentiation of varicella-zoster virus (VZV) wild-type strains and an attenuated varicella vaccine strain using a VZV open reading frame 62-based PCR. J Clin Microbiol 38: 3156-3160.
– reference: Adams SG, Dohner DE, Gelb LD. 1989. Restriction fragment differences between the genomes of the Oka varicella vaccine virus and American wild-type varicella-zoster virus. J Med Virol 29: 38-45.
– reference: Giehl KA, Müller-Sander E, Rottenkolber M, Degitz K, Volkenandt M, Berking C. 2008. Identification and characterization of 20 immunocompetent patients with simultaneous varicella zoster and herpes simplex virus infection. J Eur Acad Dermatol Venereol 22: 722-728.
– reference: LaRussa P, Lungu O, Hardy I, Gershon A, Steinberg SP, Silverstein S. 1992. Restriction fragment length polymorphism of polymerase chain reaction products from vaccine and wild-type varicella-zoster virus isolates. J Virol 66: 1016-1020.
– reference: Quinlivan M, Gershon AA, Steinberg SP, Breuer J. 2005. An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virus. J Med Virol 75: 174-180.
– reference: Tipples GA, Safronetz D, Gray M. 2003. A real-time PCR assay for the detection of varicella-zoster virus DNA and differentiation of vaccine, wild-type and control strains. J Virol Meth 113: 113-116.
– reference: Martin JH, Dohner DE, Wellinghoff WJ, Gelb LD. 1982. Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs. J Med Virol 9: 69-76.
– reference: Tang YW, Allawi HT, DeLeon-Carnes M, Li H, Day SP, Schmid DS. 2007. Detection and differentiation of wild-type and vaccine mutant varicella-zoster viruses using an Invader Plus method. J Clin Virol 40: 129-134.
– volume: 66
  start-page: 1016
  year: 1992
  end-page: 1020
  article-title: Restriction fragment length polymorphism of polymerase chain reaction products from vaccine and wild‐type varicella‐zoster virus isolates
  publication-title: J Virol
– volume: 197
  start-page: S54
  year: 2008
  end-page: S57
  article-title: Vaccine Oka variants and sequence variability in vaccine‐related skin lesions
  publication-title: J Infect Dis
– volume: 75
  start-page: 174
  year: 2005
  end-page: 180
  article-title: An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella‐zoster virus
  publication-title: J Med Virol
– volume: 181
  start-page: 1153
  year: 2000
  end-page: 1157
  article-title: Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella‐zoster virus isolates
  publication-title: J Infect Dis
– volume: 44
  start-page: 3443
  year: 2006
  end-page: 3447
  article-title: Invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2
  publication-title: J Clin Microbiol
– volume: 29
  start-page: 113
  year: 2004
  end-page: 119
  article-title: New method of differentiating wild‐type varicella‐zoster virus (VZV) strains from Oka varicella vaccine strain by VZV ORF 6‐based PCR and restriction fragment length polymorphism analysis
  publication-title: J Clin Virol
– volume: 38
  start-page: 4315
  year: 2000b
  end-page: 4319
  article-title: Rapid genotyping of varicella‐zoster virus vaccine and wild‐type strains with fluorophore‐labeled hybridization probes
  publication-title: J Clin Microbiol
– volume: 178
  start-page: S64
  year: 1998
  end-page: S66
  article-title: Polymerase chain reaction and restriction fragment length polymorphism analysis of varicella‐zoster virus isolates from the United States and other parts of the world
  publication-title: J Infect Dis
– volume: 190
  start-page: 793
  year: 2004
  end-page: 796
  article-title: Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of virus
  publication-title: J Infect Dis
– volume: 40
  start-page: 129
  year: 2007
  end-page: 134
  article-title: Detection and differentiation of wild‐type and vaccine mutant varicella‐zoster viruses using an Invader Plus method
  publication-title: J Clin Virol
– volume: 38
  start-page: 3156
  year: 2000a
  end-page: 3160
  article-title: Improved identification and differentiation of varicella‐zoster virus (VZV) wild‐type strains and an attenuated varicella vaccine strain using a VZV open reading frame 62‐based PCR
  publication-title: J Clin Microbiol
– volume: 9
  start-page: 69
  year: 1982
  end-page: 76
  article-title: Restriction endonuclease analysis of varicella‐zoster vaccine virus and wild‐type DNAs
  publication-title: J Med Virol
– volume: 352
  start-page: 2271
  year: 2005a
  end-page: 2284
  article-title: A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
  publication-title: N Engl J Med
– volume: 195
  start-page: 502
  year: 2007
  end-page: 510
  article-title: DNA sequence variability in isolates recovered from patients with postvaccination rash or herpes zoster caused by Oka varicella vaccine
  publication-title: J Infect Dis
– volume: 61
  start-page: 497
  year: 2000
  end-page: 503
  article-title: Oka varicella vaccine is distinguishable from its parental virus in DNA sequence of open reading frame 62 and its transactivation activity
  publication-title: J Med Virol
– volume: 42
  start-page: 1409
  year: 2004
  end-page: 1413
  article-title: Detection and genotyping of varicella‐zoster virus by TaqMan allelic discrimination real‐time PCR
  publication-title: J Clin Microbiol
– volume: 25
  start-page: S3
  year: 2002
  end-page: S12
  article-title: Clinical virology in real‐time
  publication-title: J Clin Virol
– year: 2005b
– volume: 113
  start-page: 113
  year: 2003
  end-page: 116
  article-title: A real‐time PCR assay for the detection of varicella‐zoster virus DNA and differentiation of vaccine, wild‐type and control strains
  publication-title: J Virol Meth
– volume: 22
  start-page: 722
  year: 2008
  end-page: 728
  article-title: Identification and characterization of 20 immunocompetent patients with simultaneous varicella zoster and herpes simplex virus infection
  publication-title: J Eur Acad Dermatol Venereol
– volume: 38
  start-page: 3116
  year: 2000
  end-page: 3118
  article-title: Evaluation of LightCycler PCR for implementation of laboratory diagnosis of herpes simplex virus infections
  publication-title: J Clin Microbiol
– volume: 14
  start-page: 31
  year: 1999
  end-page: 36
  article-title: Laboratory diagnosis of herpes zoster
  publication-title: J Clin Virol
– volume: 33
  start-page: 658
  year: 1995
  end-page: 660
  article-title: Identification of varicella‐zoster virus strains by PCR analysis of three repeat elements and a I‐site‐less region
  publication-title: J Clin Microbiol
– volume: 19
  start-page: 165
  year: 2006
  end-page: 256
  article-title: Real‐time PCR in clinical microbiology: Applications for routine laboratory testing
  publication-title: Clin Microbiol Rev
– volume: 29
  start-page: 38
  year: 1989
  end-page: 45
  article-title: Restriction fragment differences between the genomes of the Oka varicella vaccine virus and American wild‐type varicella‐zoster virus
  publication-title: J Med Virol
– ident: e_1_2_1_26_1
  doi: 10.1016/S0166-0934(03)00229-5
– ident: e_1_2_1_6_1
  doi: 10.1128/JCM.42.4.1409-1413.2004
– ident: e_1_2_1_12_1
  doi: 10.1086/514267
– ident: e_1_2_1_18_1
  doi: 10.1056/NEJMoa051016
– ident: e_1_2_1_22_1
  doi: 10.1016/S1386-6532(99)00042-6
– ident: e_1_2_1_2_1
  doi: 10.1002/jmv.1890290108
– ident: e_1_2_1_7_1
  doi: 10.1128/JCM.38.8.3116-3118.2000
– ident: e_1_2_1_20_1
  doi: 10.1086/423210
– ident: e_1_2_1_19_1
– ident: e_1_2_1_25_1
  doi: 10.1016/j.jcv.2007.07.007
– ident: e_1_2_1_14_1
  doi: 10.1128/JCM.38.12.4315-4319.2000
– ident: e_1_2_1_4_1
  doi: 10.1086/315335
– ident: e_1_2_1_3_1
  doi: 10.1128/JCM.01175-06
– ident: e_1_2_1_15_1
  doi: 10.1086/510532
– ident: e_1_2_1_13_1
  doi: 10.1128/JCM.38.9.3156-3160.2000
– ident: e_1_2_1_17_1
  doi: 10.1016/S1386-6532(02)00197-X
– ident: e_1_2_1_8_1
  doi: 10.1128/CMR.19.1.165-256.2006
– ident: e_1_2_1_10_1
  doi: 10.1002/1096-9071(200008)61:4<497::AID-JMV13>3.0.CO;2-2
– ident: e_1_2_1_5_1
  doi: 10.1086/522140
– ident: e_1_2_1_21_1
  doi: 10.1002/jmv.20253
– ident: e_1_2_1_9_1
  doi: 10.1111/j.1468-3083.2008.02587.x
– ident: e_1_2_1_16_1
  doi: 10.1002/jmv.1890090110
– ident: e_1_2_1_24_1
  doi: 10.1016/S1386-6532(03)00112-4
– volume: 33
  start-page: 658
  year: 1995
  ident: e_1_2_1_23_1
  article-title: Identification of varicella‐zoster virus strains by PCR analysis of three repeat elements and a PstI‐site‐less region
  publication-title: J Clin Microbiol
  doi: 10.1128/jcm.33.3.658-660.1995
– ident: e_1_2_1_11_1
  doi: 10.1128/JVI.66.2.1016-1020.1992
SSID ssj0008922
Score 2.1525848
Snippet A real-time PCR assay was developed to identify varicella-zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with...
A real‐time PCR assay was developed to identify varicella‐zoster virus (VZV) and herpes simplex virus (HSV) DNA in clinical specimens from subjects with...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
wiley
istex
fao
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1310
SubjectTerms beta-Globins - genetics
Biological and medical sciences
Chickenpox Vaccine
clinical trial
diagnosis of herpes zoster
Diagnosis, Differential
DNA Primers
Fundamental and applied biological sciences. Psychology
Herpes Simplex - diagnosis
Herpes Simplex Virus Vaccines
Herpes Zoster - diagnosis
Herpesvirus 3, Human - classification
Herpesvirus 3, Human - genetics
Herpesvirus 3, Human - isolation & purification
Human viral diseases
Humans
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - standards
Polymorphism, Single Nucleotide
Reference Standards
Sensitivity and Specificity
Shingles Prevention Study
Simplexvirus - classification
Simplexvirus - genetics
Simplexvirus - isolation & purification
Techniques used in virology
Vaccines
Viral diseases
Virology
VZV ORF 62
zoster vaccine
Title real-time PCR assay to identify and discriminate among wild-type and vaccine strains of varicella-zoster virus and herpes simplex virus in clinical specimens, and comparison with the clinical diagnoses
URI https://api.istex.fr/ark:/67375/WNG-K45GJ6R4-R/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.21506
https://www.ncbi.nlm.nih.gov/pubmed/19475609
https://www.proquest.com/docview/46302938
https://www.proquest.com/docview/67321203
https://pubmed.ncbi.nlm.nih.gov/PMC4217208
Volume 81
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6VHhAXHuVR82hXCKEecOrH-iVOVUVbBaVCgUAPSKt9GUKLU8VJ1PbET-Cv8Rf4Jczsxg6BVkLcLHvWm92dnf3imfmGkGepKAHUy8DXIo19BnvCz8Ms9AujRBaKPI0zTBTuHaYHA9Y9So5WyMsmF8bxQ7Qf3HBnWHuNG1zIentBGvrl66wTIT8e2F-M1UJA1F9QR-WF8yCAJfDhDEoaVqEg2m5bLp1F10oxAoSKk3uGEZKihkkqXXWLy-Dn31GUv6Nbezzt3SIfm4G5qJTjznQiO-riD87H_xz5bXJzDlvpjtOzO2TFVGvkem_umL9LfuxQQJ8nP799x2L19M1unwIqF-d0MqJDmwtcnlNRaYpZwK6S2MRQW-mIwo_Q2BD-EVuRmVD4Ulrb8hU1HZVwC7mPQGNB7gLTUsZ0NhxPaysPWndqaloPkej4bP5gWNEm6ZNiNikWMahfWHnVll6k-BWaAgReyGoXemjqe2Sw9-rd7oE_rxbhqwRwqy_DRIg4FgEALlWqXGeJkKEOZGqSKNVhFJWBTtBLWMpYl4USjJUsNDIxJlRSxPfJajWqzDqhSmsZZUJJJhVjWS50rAqmmE5MzoxKPbLV6A1Xcyp1nJIT7kigIw5LxO0SeeRpK3rq-EMuE1oH5ePiE4ydD95G6E0GnIy8PB55bjWybSzGxxiLlyX8w-E-f82S_W7aZ7zvkY0llW0bQA8xxhB7ZLPRYQ4mxC5aZUbTmrM0DgD15VdLQIcAcQJ4xwOn84uxFCwD0Fx4JFvaDa0A0pcvP6mGny2NOcPaaAH0umWV_erp4d3ee3vx8N9FH5Ebzu-HgdWPyepkPDVPAD5O5Ia1E78A841zzg
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa2IQEv3GHhslkIoT2QLhfnUomXaWIr3VqhsrK9IMu3QNlIp6attj3xE_hr_AV-Cec4TUphkxBvUXIcx_ax_cXnnO8Q8iIWGYB66blaxKHLYE64qZ_4btMokfgijcMEA4U73bjVZ-2j6GiJvK5iYUp-iPrADWeGXa9xguOB9OacNfTL12kjQIK8ZXINM3rbH6renDwqbZY2BFgLXNiFoopXyAs266ILu9FyJoaAUbF7z9BHUhTQTVmZ3-IyAPq3H-Xv-NZuUDu3yceqaaVfynFjMpYNdfEH6-P_tv0OuTVDrnSrVLW7ZMnk98j1zsw2f5_82KIAQE9-fvuO-erpu-0eBWAuzul4SAc2HDg7pyLXFAOBy2RiY0NtsiMKX6GxIPwUW5GpUPhSWtgMFgUdZnAL6Y9AaUHuAiNTRnQ6GE0KKw-Kd2oKWgyQ6_hs9mCQ0yruk2JAKeYxKF5ZeVVnX6R4EE0BBc9ldel9aIoHpL_z5mC75c4SRrgqAujqSj8SIgyFB5hLZSrVSSSkrz0ZmyiItR8EmacjNBRmMtRZUwnGMuYbGRnjKynCh2QlH-ZmlVCltQwSoSSTirEkFTpUTaaYjkzKjIodslEpDlczNnXskhNe8kAHHIaI2yFyyPNa9LSkELlMaBW0j4tP0Hbefx-gQRmgMlLzOOSlVcm6sBgdozteEvHD7i7fY9FuO-4x3nPI2oLO1gWghhDdiB2yXikxh1XEDlpuhpOCszj0APilV0tAhYByPHjHo1Lp521psgRwc9MhycJ0qAWQwXzxST74bJnMGaZH86DWDavtV3cPb3c-2IvH_y66Tm60Djr7fP9td-8JuVmaAdHP-ilZGY8m5hmgybFcs4vGL8vsd-k
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa2IU28cIeVy2YhhPZAulycm3iaNrrR0WoqDPaAZPkWKBtp1bTVtid-An-Nv8Av4RynSSlsEuItSo7j2v5sf43P-Q4hzyKRAamXrqNFFDgM5oSTeLHnpEaJ2BNJFMQYKNzpRvtHrH0cHi-Rl1UsTKkPUX9ww5lh12uc4EOdbc1FQ798nTZ91MdbJtdY5CYI6d3eXDsqScsjBFgKHNiEwkpWyPW36qILm9FyJgZAUbF3z9BFUhTQS1mZ3uIy_vm3G-Xv9NbuT62b5GPVstIt5aQ5GcumuvhD9PE_m36L3JjxVrpdAu02WTL5HbLamZ3M3yU_tinQz9Of375jtnp6uNOjQMvFOR0PaN8GA2fnVOSaYhhwmUpsbKhNdUThR2gsCH-JrclUKHwpLWz-ioIOMriF4kcAWbC7wLiUEZ32R5PC2gPshqagRR-Vjs9mD_o5raI-KYaTYhaD4oW1V3XuRYqfoSlw4LmtLn0PTXGPHLVevdvZd2bpIhwVAnF1pBcKEQTCBcalMpXoOBTS066MTOhH2vP9zNUhHhNmMtBZqgRjGfOMDI3xlBTBfbKSD3KzRqjSWvqxUJJJxVicCB2olCmmQ5Mwo6IG2axww9VMSx275JSXKtA-hyHidoga5GltOiwFRC4zWgPwcfEJ2s6P3vp4nAxEGYV5GuS5RWRdWIxO0BkvDvmH7h4_YOFeO-ox3muQ9QXI1gWghgCdiBtko8IwhzXEDlpuBpOCsyhwgfYlV1tAhcBxXHjHgxLz87akLAbWnDZIvDAbagPUL198kvc_Wx1zhsnRXKh104L96u7h7c57e_Hw3003yOrhbou_ed09eESul2eA6GT9mKyMRxPzBKjkWK7bJeMXSH12oQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+real-time+PCR+assay+to+identify+and+discriminate+among+wild-type+and+vaccine+strains+of+varicella-zoster+virus+and+herpes+simplex+virus+in+clinical+specimens%2C+and+comparison+with+the+clinical+diagnoses&rft.jtitle=Journal+of+medical+virology&rft.au=Harbecke%2C+Ruth&rft.au=Oxman%2C+Michael+N&rft.au=Arnold%2C+Beth+A&rft.au=Ip%2C+Charlotte&rft.date=2009-07-01&rft.issn=0146-6615&rft.volume=81&rft.issue=7&rft.spage=1310&rft.epage=1322&rft_id=info:doi/10.1002%2Fjmv.21506&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0146-6615&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0146-6615&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0146-6615&client=summon