Profiling of diffuse large B-cell lymphoma by immunohistochemistry: identification of prognostic subgroups

• Published in: European journal of haematology Vol. 79; no. 6; pp. 501 - 507
• Main Authors: Sjö, Lene Dissing, Poulsen, Christian Bjørn, Hansen, Mads, Møller, Michael Boe, Ralfkiaer, Elisabeth
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2007
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Bcl-2; Bcl-6; CD10; diffuse large B-cell lymphoma; DNA-Binding Proteins - metabolism; Humans; Immunohistochemistry - methods; immunohistology; Interferon Regulatory Factors - metabolism; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - metabolism; Lymphoma, Non-Hodgkin - mortality; Lymphoma, Non-Hodgkin - pathology; Middle Aged; Models, Biological; Neprilysin - biosynthesis; Prognosis; Proto-Oncogene Proteins c-bcl-2 - metabolism; Proto-Oncogene Proteins c-bcl-6; Treatment Outcome

Diffuse large B‐cell lymphoma (DLBCL) is a frequent lymphoma subtype with a heterogeneous behavior and a variable response to conventional chemotherapy. This clinical diversity is believed to reflect differences in the molecular pathways leading to lymphomagenesis. In this study, we have analyzed pr...