Human autoimmune diseases: a comprehensive update

There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most importantly, research advances in new therapies. The importance of autoimmunity and the mechanisms that lead to clinical disease were first recogniz...

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Published in	Journal of internal medicine Vol. 278; no. 4; pp. 369 - 395
Main Authors	Wang, Lifeng, Wang, Fu‐Sheng, Gershwin, M. Eric
Format	Journal Article
Language	English
Published	England 01.10.2015
Subjects	autoantibodies Autoimmune Diseases - epidemiology Autoimmune Diseases - etiology Autoimmune Diseases - genetics Autoimmune Diseases - therapy Environmental Exposure Female Genetic Predisposition to Disease genetics and autoimmunity Humans Immune Tolerance Immunopathology Male Models, Biological Twin Studies as Topic Immunopathology autoantibodies genetics and autoimmunity Immune tolerance
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Abstract	There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most importantly, research advances in new therapies. The importance of autoimmunity and the mechanisms that lead to clinical disease were first recognized about 50 years ago following the pioneering studies of Macfarlane Burnett and his Nobel Prize‐winning hypothesis of the ‘forbidden clone’. Such pioneering efforts led to a better understanding not only of autoimmunity, but also of lymphoid cell development, thymic education, apoptosis and deletion of autoreactive cells. Contemporary theories suggest that the development of an autoimmune disease requires a genetic predisposition and environmental factors that trigger the immune pathways that lead, ultimately, to tissue destruction. Despite extensive research, there are no genetic tools that can be used clinically to predict the risk of autoimmune disease. Indeed, the concordance of autoimmune disease in identical twins is 12–67%, highlighting not only a role for environmental factors, but also the potential importance of stochastic or epigenetic phenomena. On the other hand, the identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis. Further advances involving the use of multiplex platforms for diagnosis and identification of new therapeutic agents should lead to major breakthroughs within the next decade.
AbstractList	There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most importantly, research advances in new therapies. The importance of autoimmunity and the mechanisms that lead to clinical disease were first recognized about 50 years ago following the pioneering studies of Macfarlane Burnett and his Nobel Prize‐winning hypothesis of the ‘forbidden clone’. Such pioneering efforts led to a better understanding not only of autoimmunity, but also of lymphoid cell development, thymic education, apoptosis and deletion of autoreactive cells. Contemporary theories suggest that the development of an autoimmune disease requires a genetic predisposition and environmental factors that trigger the immune pathways that lead, ultimately, to tissue destruction. Despite extensive research, there are no genetic tools that can be used clinically to predict the risk of autoimmune disease. Indeed, the concordance of autoimmune disease in identical twins is 12–67%, highlighting not only a role for environmental factors, but also the potential importance of stochastic or epigenetic phenomena. On the other hand, the identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis. Further advances involving the use of multiplex platforms for diagnosis and identification of new therapeutic agents should lead to major breakthroughs within the next decade. There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most importantly, research advances in new therapies. The importance of autoimmunity and the mechanisms that lead to clinical disease were first recognized about 50 years ago following the pioneering studies of Macfarlane Burnett and his Nobel Prize-winning hypothesis of the 'forbidden clone'. Such pioneering efforts led to a better understanding not only of autoimmunity, but also of lymphoid cell development, thymic education, apoptosis and deletion of autoreactive cells. Contemporary theories suggest that the development of an autoimmune disease requires a genetic predisposition and environmental factors that trigger the immune pathways that lead, ultimately, to tissue destruction. Despite extensive research, there are no genetic tools that can be used clinically to predict the risk of autoimmune disease. Indeed, the concordance of autoimmune disease in identical twins is 12-67%, highlighting not only a role for environmental factors, but also the potential importance of stochastic or epigenetic phenomena. On the other hand, the identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis. Further advances involving the use of multiplex platforms for diagnosis and identification of new therapeutic agents should lead to major breakthroughs within the next decade.There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most importantly, research advances in new therapies. The importance of autoimmunity and the mechanisms that lead to clinical disease were first recognized about 50 years ago following the pioneering studies of Macfarlane Burnett and his Nobel Prize-winning hypothesis of the 'forbidden clone'. Such pioneering efforts led to a better understanding not only of autoimmunity, but also of lymphoid cell development, thymic education, apoptosis and deletion of autoreactive cells. Contemporary theories suggest that the development of an autoimmune disease requires a genetic predisposition and environmental factors that trigger the immune pathways that lead, ultimately, to tissue destruction. Despite extensive research, there are no genetic tools that can be used clinically to predict the risk of autoimmune disease. Indeed, the concordance of autoimmune disease in identical twins is 12-67%, highlighting not only a role for environmental factors, but also the potential importance of stochastic or epigenetic phenomena. On the other hand, the identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis. Further advances involving the use of multiplex platforms for diagnosis and identification of new therapeutic agents should lead to major breakthroughs within the next decade.
Author	Wang, Fu‐Sheng Wang, Lifeng Gershwin, M. Eric
Author_xml	– sequence: 1 givenname: Lifeng surname: Wang fullname: Wang, Lifeng organization: Beijing 302 Hospital – sequence: 2 givenname: Fu‐Sheng surname: Wang fullname: Wang, Fu‐Sheng organization: Beijing 302 Hospital – sequence: 3 givenname: M. Eric surname: Gershwin fullname: Gershwin, M. Eric organization: University of California at Davis School of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26212387$$D View this record in MEDLINE/PubMed
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crossref_primary_10_3389_fimmu_2022_864307 crossref_primary_10_3390_metabo13090987 crossref_primary_10_1016_j_mucimm_2023_05_006 crossref_primary_10_1134_S1068162024030762 crossref_primary_10_1097_MD_0000000000007855 crossref_primary_10_1136_rmdopen_2022_002907 crossref_primary_10_1016_j_ejmech_2021_113393 crossref_primary_10_3389_fimmu_2023_1216901 crossref_primary_10_1016_j_imbio_2021_152069 crossref_primary_10_1038_s41598_020_68212_x crossref_primary_10_2174_1874312902014010015 crossref_primary_10_1089_can_2020_0183 crossref_primary_10_3390_ijerph19084503 crossref_primary_10_1002_slct_202003162 crossref_primary_10_1016_j_bioactmat_2024_02_022 crossref_primary_10_1016_j_intimp_2024_113175 crossref_primary_10_1186_s12929_024_01035_4 crossref_primary_10_3390_ijms241713609 crossref_primary_10_1016_j_intimp_2020_106646 crossref_primary_10_24017_Science_2022_1_4 crossref_primary_10_1186_s40795_021_00446_y crossref_primary_10_1002_mco2_349 crossref_primary_10_1007_s00018_019_03113_5 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crossref_primary_10_2147_IJN_S440612 crossref_primary_10_1186_s12964_024_01714_7 crossref_primary_10_1007_s00586_023_07870_7 crossref_primary_10_3390_ijms24109060 crossref_primary_10_1080_16078454_2024_2433799 crossref_primary_10_3390_antib13010010 crossref_primary_10_1002_adbi_201800219 crossref_primary_10_1016_j_fitote_2020_104694 crossref_primary_10_1016_j_jconrel_2021_09_037 crossref_primary_10_1093_jalm_jfab132 crossref_primary_10_3389_fcell_2022_851032 crossref_primary_10_3389_fimmu_2021_672346 crossref_primary_10_1016_j_heliyon_2023_e19861 crossref_primary_10_1016_j_jaut_2022_102919 crossref_primary_10_1016_j_mrgentox_2021_503334 crossref_primary_10_1080_10717544_2023_2289846 crossref_primary_10_1080_17474124_2018_1517044 crossref_primary_10_1016_j_jtherbio_2022_103425 crossref_primary_10_1016_j_intell_2017_09_001 crossref_primary_10_1016_j_mad_2023_111797 crossref_primary_10_3390_jpm13111600 crossref_primary_10_53933_sspmlp_v2i1_39 crossref_primary_10_1016_j_jff_2023_105942 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crossref_primary_10_1111_jam_15782 crossref_primary_10_3389_fnmol_2022_1021207 crossref_primary_10_3390_ijms22158234 crossref_primary_10_1016_j_addr_2023_115141 crossref_primary_10_3390_ijms25063123 crossref_primary_10_3390_jcm9030766 crossref_primary_10_3389_fimmu_2024_1300457 crossref_primary_10_15446_cr_v9n1_109404
Cites_doi	10.1016/j.clim.2012.10.005 10.1038/nature02596 10.1038/ng.2272 10.1002/art.20992 10.1210/jc.81.7.2595 10.1111/j.1753-4887.2008.00094.x 10.1507/endocrj.EJ14-0246 10.1053/j.gastro.2006.05.056 10.1615/CritRevImmunol.v32.i3.10 10.1016/j.jaut.2009.02.012 10.1038/ng1297-393 10.1056/NEJMra043898 10.1007/s12016-012-8342-y 10.1038/ni.3024 10.1055/s-0034-1383729 10.1002/hep.23783 10.1002/ibd.21830 10.1002/hep.23294 10.1002/1529-0131(200105)44:5<1122::AID-ANR193>3.0.CO;2-D 10.1016/j.jaut.2013.02.001 10.1016/j.jaut.2012.11.002 10.1084/jem.170.1.59 10.1016/j.autrev.2014.01.028 10.1016/j.autrev.2009.12.002 10.1016/j.jaut.2014.05.008 10.1016/j.jaut.2009.12.009 10.1136/gutjnl-2014-306944 10.1007/s00281-006-0031-6 10.1016/j.mam.2014.12.004 10.1038/nrendo.2013.161 10.1016/j.jaut.2014.02.008 10.1186/ar3844 10.1007/s11882-014-0462-4 10.1212/WNL.53.6.1367-a 10.1007/s00281-014-0446-4 10.1371/journal.pgen.1002216 10.1186/1471-2180-10-175 10.1038/ajg.2014.55 10.1016/B978-0-444-52001-2.00009-1 10.1038/ni1178 10.12968/hmed.2014.75.5.268 10.1007/s10620-014-3284-2 10.1038/nri724 10.1038/358155a0 10.1002/jmv.2151 10.1136/gutjnl-2014-307891 10.1210/me.2011-0068 10.1136/annrheumdis-2013-203305 10.1055/s-2005-916319 10.1097/MOG.0000000000000041 10.1016/j.jaut.2014.01.010 10.1111/jop.12187 10.1016/j.crohns.2007.11.001 10.1016/j.coi.2014.08.005 10.1038/nature12199 10.1136/gut.45.3.395 10.1097/MD.0000000000000309 10.1055/s-0034-1383730 10.1016/j.jaut.2014.01.004 10.1136/gutjnl-2014-306931 10.1007/s10495-015-1090-8 10.3109/08916934.2012.748752 10.1016/j.jaut.2011.06.005 10.1371/journal.pone.0033387 10.1016/j.autrev.2005.08.005 10.1016/S0140-6736(05)66990-5 10.1006/clin.1997.4412 10.1055/s-0033-1341511 10.1016/j.jaut.2014.01.001 10.1016/j.autrev.2014.01.029 10.1517/14656566.2014.922955 10.3389/fgene.2014.00071 10.1016/j.jaut.2013.01.008 10.1056/NEJM200108023450506 10.1016/j.jaut.2014.01.007 10.1038/nrrheum.2012.58 10.1002/ana.22366 10.1055/s-0034-1383731 10.1055/s-0034-1383725 10.1016/j.jaut.2014.01.019 10.1016/j.vaccine.2015.01.073 10.1186/ar3206 10.1007/BF02686087 10.1016/j.jneuroim.2012.03.003 10.1016/j.ygeno.2015.01.001 10.1016/j.jaut.2014.01.029 10.1016/S0140-6736(14)60128-8 10.4049/jimmunol.76.6.417 10.1007/s00281-014-0439-3 10.1136/bmj.299.6710.1259 10.1016/j.jaut.2014.01.022 10.1016/j.cellsig.2013.05.006 10.1016/j.jaut.2014.01.020 10.2337/dc10-S062 10.1016/j.ecl.2010.05.011 10.1080/08916930500484849 10.1053/j.gastro.2011.10.001 10.1136/adc.65.8.909 10.1517/14728222.2013.773311 10.1128/IAI.69.9.5345-5351.2001 10.1002/hep.24630 10.1016/j.jaut.2014.01.018 10.1111/j.1464-5491.2006.01925.x 10.1056/NEJMoa032534 10.1016/j.autrev.2015.01.017 10.1097/MIB.0000000000000179 10.1016/j.jaut.2014.01.021 10.1007/s11684-015-0388-9 10.1007/s11882-013-0407-3 10.1016/j.coi.2005.09.006 10.1016/j.jaut.2014.01.006 10.1016/j.autrev.2014.01.025 10.4049/jimmunol.171.11.5778 10.1016/S0140-6736(13)60954-X 10.1016/j.jaut.2007.11.009 10.1016/j.trsl.2014.09.006 10.7754/Clin.Lab.2014.131117 10.1002/hep.27313 10.1016/j.jaut.2014.03.005 10.1136/annrheumdis‐2014‐206334 10.1016/j.coi.2012.09.001 10.1038/nature10251 10.1093/hmg/ddu429 10.1016/j.mehy.2008.06.029 10.1056/NEJMra1100030 10.1016/j.jaut.2011.12.007 10.1056/NEJM199510123331502 10.3389/fimmu.2014.00164 10.1016/S1499-3872(12)60136-2 10.1007/s12020-012-9703-2 10.1016/j.jaut.2012.12.007 10.4049/jimmunol.154.7.3173 10.1016/j.bbrc.2014.07.085 10.4049/jimmunol.1400844 10.1016/j.semarthrit.2008.10.007 10.1007/s00296-012-2590-2 10.1046/j.1440-1746.2003.03165.x 10.1007/s11926-013-0372-9 10.1056/NEJMra1004965 10.1016/j.autrev.2012.07.007 10.1016/j.jaut.2011.11.003 10.1146/annurev.iy.09.040191.001331 10.1016/j.jaut.2013.01.009 10.1016/j.jaut.2014.01.011 10.1016/j.jaut.2014.07.002 10.1016/j.jaut.2012.12.006 10.1007/BF02806528 10.1212/01.wnl.0000326576.91097.87 10.1016/j.jaut.2014.03.003 10.1056/NEJM199006283222601 10.1016/j.crohns.2009.12.003 10.1002/hep.27230 10.1136/gutjnl-2013-306711 10.7554/eLife.01202 10.1016/j.jaut.2013.02.004 10.1016/j.jaut.2014.01.003 10.3109/10408369708998095 10.1146/annurev-pathol-020712-164014 10.1038/ng.543 10.1016/S0140-6736(12)62163-1 10.1016/j.molimm.2014.02.018 10.1084/jem.20030530 10.1136/ard.2010.142109 10.1097/00002281-200307000-00010 10.1371/journal.pone.0036278 10.1056/NEJMoa035075 10.15252/embj.201489966 10.1056/NEJMct1207259 10.1016/j.bpg.2014.04.003 10.1038/nrrheum.2014.109 10.1016/j.jaut.2014.11.006 10.2217/ijr.12.82 10.1016/j.jaut.2013.11.005 10.1016/j.autrev.2014.01.013 10.12659/AOT.890753 10.1016/j.autrev.2014.10.012 10.1016/j.jpeds.2013.10.029 10.1016/j.jaut.2007.05.002 10.1016/j.autrev.2007.01.006 10.1530/JOE-13-0544 10.1016/j.autrev.2009.11.010 10.1517/17425255.2015.992779 10.4161/epi.29446 10.1038/nrgastro.2013.232 10.1146/annurev-pathol-012513-104713 10.1016/S0140-6736(03)13492-7 10.1016/S1568-9972(01)00016-7 10.1146/annurev-genom-082908-150013 10.1038/nrrheum.2015.7 10.1136/ard.2010.138461 10.1016/S0140-6736(96)02293-3 10.1542/peds.2013-1652 10.1002/hep.22322 10.1093/hmg/ddu455 10.1007/s00296-013-2889-7 10.1111/cei.12321 10.1111/j.1600-051X.2009.01496.x 10.1093/rheumatology/kei107 10.1136/annrheumdis-2013-204627 10.1073/pnas.071050898 10.1111/j.1582-4934.2011.01456.x 10.1055/s-0034-1383726 10.1016/j.jaut.2014.01.016 10.1002/acr.21591 10.1016/j.autrev.2012.12.005 10.1186/1471-2350-12-111 10.1002/art.1780330711 10.1093/rheumatology/keq214 10.1038/ng.249 10.1155/2014/527895 10.1093/hmg/ddt520 10.12659/MSM.890686 10.4049/jimmunol.0900709 10.1016/j.jaut.2014.01.027 10.1016/j.clim.2014.12.013 10.1016/j.jaut.2009.12.003 10.1016/j.jaut.2013.01.006 10.1016/j.it.2009.05.005 10.1186/ar1702 10.1111/ced.12390 10.1016/j.jaut.2013.01.010 10.1016/B978-0-444-52001-2.00020-0 10.1097/01.EPX.0000452287.65133.fc 10.1111/cei.12217 10.1097/BOR.0000000000000012 10.1016/j.jaut.2014.01.015 10.1177/0961203313512881 10.1016/j.jaut.2008.04.009 10.1002/hep.22906 10.1136/annrheumdis-2013-204486 10.1038/ng.2792 10.1016/S0168-8278(99)80297-9 10.3109/08830185.2014.917411 10.1111/j.1600-065X.1998.tb01207.x 10.1155/2013/535738 10.1016/S1474-4422(14)70041-9 10.1111/apt.12373 10.1177/1352458511421055 10.1038/ni0705-639 10.1002/art.34473 10.2174/138955708785132756 10.1097/BOR.0000000000000086 10.1038/ng.717 10.1056/NEJMra071600 10.1016/j.jaut.2013.10.001
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References	2010; 10 2011; 476 2013; 2 2006; 39 2013; 368 1999; 45 2014; 26 2008; 35 2012; 18 2010; 184 2012; 16 2008; 30 2008; 31 2014; 28 2012; 246 2001; 44 2012; 14 2013; 8 2012; 12 2012; 11 2014; 23 2013; 9 2014; 20 2009; 10 2006; 23 2013; 2013 2006; 24 2006; 28 1992; 358 2014; 15 2014; 14 2007; 6 2014; 13 1999; 53 2014; 19 2014; 18 2011; 69 2012; 24 2014; 122 2014; 93 2010; 4 2011; 365 2014; 11 2010; 9 2014; 10 1998; 164 2010; 34 2015; 57 2010; 33 1990; 33 2010; 35 2005; 353 2010; 39 2002; 1 2002; 2 2003; 171 2014; 2014 2012; 38 1995; 154 2012; 32 2011; 7 2014; 43 2004; 429 2015; 194 2010; 42 2010; 49 2003; 349 2006; 45 2005; 366 2015; 64 1997; 34 2002; 66 2008; 48 2005; 7 2014; 36 2005; 6 1999; 31 1996; 81 1992; 27 2014; 39 2014; 30 2008; 40 2005; 17 2012; 44 2014; 384 2014; 34 2010; 52 2014; 33 2012; 42 2010; 51 2014; 32 2014; 31 2015; 34 1997; 84 2012; 2012 2013; 25 2015; 105 2015; 33 2003; 15 2006; 131 2008; 8 2011; 13 2003; 18 2011; 12 1995; 333 2014; 63 2007; 32 2014; 177 2014; 452 2008; 2 2014; 61 2012; 55 2014; 60 2008; 71 2014; 175 2003; 198 2001; 345 1996; 348 2005; 25 2007; 29 2014; 5 2013; 15 2013; 17 2010; 69 2009; 50 2013; 12 2015; 42 2014; 59 1997; 17 2008; 66 2011; 25 2014; 9 2014; 52 2014; 51 2014; 8 2014; 50 2014; 7 2014; 164 2012; 64 2014; 54 2014; 53 2003; 361 2001; 98 2015; 14 2012; 142 1989; 299 2013; 43 2013; 46 2010 2013; 45 1956; 76 2013; 42 2015; 11 2013; 41 2015; 165 2006; 5 2013; 146 2013; 382 2011; 37 1990; 322 2015; 9 2001; 69 1991; 9 2014; 89 2015; 24 2007; 357 2009; 36 2014; 106 1990; 65 2009; 30 2014; 109 2009; 32 2013; 38 2013; 33 2015; 157 2015; 20 2004; 350 1989; 170 2014; 48–49 2005; 52 2013; 498 2014 2013; 132 2014; 73 2012; 7 2012; 4 2012; 8 2014; 222 2014; 75 e_1_2_11_70_1 e_1_2_11_93_1 e_1_2_11_200_1 e_1_2_11_223_1 e_1_2_11_246_1 e_1_2_11_186_1 e_1_2_11_32_1 e_1_2_11_55_1 e_1_2_11_78_1 e_1_2_11_29_1 e_1_2_11_125_1 e_1_2_11_4_1 e_1_2_11_148_1 e_1_2_11_102_1 Moen K (e_1_2_11_85_1) 2006; 24 e_1_2_11_163_1 Alidjinou EK (e_1_2_11_226_1) 2014; 18 e_1_2_11_140_1 e_1_2_11_211_1 e_1_2_11_257_1 e_1_2_11_81_1 e_1_2_11_197_1 e_1_2_11_234_1 e_1_2_11_20_1 e_1_2_11_66_1 e_1_2_11_89_1 e_1_2_11_43_1 e_1_2_11_17_1 e_1_2_11_136_1 e_1_2_11_159_1 e_1_2_11_113_1 e_1_2_11_208_1 e_1_2_11_174_1 e_1_2_11_151_1 e_1_2_11_201_1 e_1_2_11_247_1 e_1_2_11_92_1 e_1_2_11_224_1 e_1_2_11_31_1 e_1_2_11_77_1 e_1_2_11_54_1 e_1_2_11_103_1 e_1_2_11_126_1 e_1_2_11_149_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_141_1 e_1_2_11_164_1 Shoenfeld Y (e_1_2_11_239_1) 2010 e_1_2_11_190_1 e_1_2_11_212_1 e_1_2_11_235_1 e_1_2_11_258_1 e_1_2_11_80_1 Cojocaru M (e_1_2_11_232_1) 2014; 52 e_1_2_11_198_1 e_1_2_11_250_1 e_1_2_11_88_1 e_1_2_11_42_1 e_1_2_11_65_1 e_1_2_11_114_1 e_1_2_11_16_1 e_1_2_11_137_1 e_1_2_11_39_1 e_1_2_11_152_1 e_1_2_11_175_1 e_1_2_11_209_1 e_1_2_11_180_1 e_1_2_11_72_1 e_1_2_11_248_1 e_1_2_11_202_1 e_1_2_11_225_1 e_1_2_11_188_1 e_1_2_11_57_1 e_1_2_11_240_1 Hoffmanova I (e_1_2_11_107_1) 2014 e_1_2_11_34_1 e_1_2_11_11_1 e_1_2_11_104_1 e_1_2_11_127_1 e_1_2_11_2_1 e_1_2_11_165_1 e_1_2_11_142_1 Gallo A (e_1_2_11_203_1) 2014; 32 e_1_2_11_83_1 e_1_2_11_191_1 e_1_2_11_236_1 e_1_2_11_60_1 e_1_2_11_259_1 e_1_2_11_213_1 e_1_2_11_45_1 e_1_2_11_199_1 e_1_2_11_251_1 e_1_2_11_68_1 e_1_2_11_22_1 e_1_2_11_115_1 e_1_2_11_138_1 e_1_2_11_19_1 e_1_2_11_176_1 e_1_2_11_153_1 e_1_2_11_130_1 e_1_2_11_94_1 e_1_2_11_181_1 e_1_2_11_71_1 e_1_2_11_249_1 e_1_2_11_10_1 e_1_2_11_56_1 e_1_2_11_189_1 e_1_2_11_79_1 e_1_2_11_241_1 e_1_2_11_33_1 e_1_2_11_105_1 e_1_2_11_128_1 e_1_2_11_3_1 e_1_2_11_143_1 e_1_2_11_166_1 Ohishi K (e_1_2_11_110_1) 1995; 154 e_1_2_11_120_1 e_1_2_11_82_1 e_1_2_11_192_1 e_1_2_11_237_1 Mok CC (e_1_2_11_260_1) 2014; 8 e_1_2_11_214_1 e_1_2_11_21_1 e_1_2_11_44_1 e_1_2_11_67_1 e_1_2_11_252_1 e_1_2_11_18_1 e_1_2_11_139_1 e_1_2_11_116_1 e_1_2_11_154_1 e_1_2_11_177_1 Francque S (e_1_2_11_155_1) 2012; 4 e_1_2_11_131_1 e_1_2_11_182_1 e_1_2_11_204_1 e_1_2_11_227_1 e_1_2_11_242_1 e_1_2_11_36_1 e_1_2_11_74_1 e_1_2_11_97_1 e_1_2_11_13_1 e_1_2_11_118_1 e_1_2_11_106_1 e_1_2_11_48_1 e_1_2_11_121_1 e_1_2_11_167_1 e_1_2_11_144_1 e_1_2_11_238_1 e_1_2_11_215_1 e_1_2_11_253_1 e_1_2_11_47_1 e_1_2_11_230_1 e_1_2_11_24_1 e_1_2_11_62_1 e_1_2_11_129_1 e_1_2_11_8_1 Vaahtovuo J (e_1_2_11_86_1) 2008; 35 e_1_2_11_117_1 e_1_2_11_59_1 e_1_2_11_178_1 e_1_2_11_132_1 Quintero‐Ronderos P (e_1_2_11_46_1) 2012; 2012 e_1_2_11_170_1 e_1_2_11_50_1 e_1_2_11_220_1 e_1_2_11_183_1 e_1_2_11_205_1 e_1_2_11_243_1 e_1_2_11_58_1 e_1_2_11_119_1 e_1_2_11_35_1 e_1_2_11_73_1 e_1_2_11_12_1 e_1_2_11_96_1 e_1_2_11_122_1 e_1_2_11_145_1 e_1_2_11_168_1 e_1_2_11_217_1 e_1_2_11_160_1 e_1_2_11_61_1 e_1_2_11_194_1 e_1_2_11_216_1 e_1_2_11_231_1 e_1_2_11_254_1 e_1_2_11_69_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_84_1 e_1_2_11_156_1 e_1_2_11_179_1 e_1_2_11_133_1 e_1_2_11_228_1 e_1_2_11_171_1 e_1_2_11_91_1 e_1_2_11_221_1 e_1_2_11_184_1 e_1_2_11_244_1 e_1_2_11_30_1 e_1_2_11_99_1 Marino M (e_1_2_11_187_1) 2014 e_1_2_11_53_1 e_1_2_11_76_1 e_1_2_11_6_1 e_1_2_11_27_1 e_1_2_11_169_1 e_1_2_11_100_1 e_1_2_11_146_1 e_1_2_11_123_1 e_1_2_11_218_1 e_1_2_11_161_1 e_1_2_11_195_1 e_1_2_11_255_1 Hu N (e_1_2_11_51_1) 2008; 35 e_1_2_11_41_1 e_1_2_11_87_1 e_1_2_11_108_1 e_1_2_11_64_1 e_1_2_11_15_1 e_1_2_11_111_1 e_1_2_11_134_1 e_1_2_11_38_1 e_1_2_11_157_1 Lv B (e_1_2_11_193_1) 2014; 7 e_1_2_11_206_1 e_1_2_11_229_1 e_1_2_11_172_1 e_1_2_11_222_1 e_1_2_11_90_1 e_1_2_11_185_1 e_1_2_11_245_1 e_1_2_11_14_1 e_1_2_11_52_1 e_1_2_11_98_1 e_1_2_11_75_1 e_1_2_11_7_1 e_1_2_11_147_1 e_1_2_11_26_1 e_1_2_11_49_1 e_1_2_11_101_1 e_1_2_11_124_1 e_1_2_11_219_1 e_1_2_11_162_1 e_1_2_11_210_1 e_1_2_11_233_1 e_1_2_11_256_1 Bascunan‐Gamboa KA (e_1_2_11_196_1) 2014; 106 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_63_1 e_1_2_11_109_1 e_1_2_11_158_1 e_1_2_11_37_1 e_1_2_11_135_1 Afridi HI (e_1_2_11_95_1) 2014; 60 e_1_2_11_112_1 e_1_2_11_150_1 e_1_2_11_173_1 e_1_2_11_207_1
References_xml	– volume: 41 start-page: 25 year: 2013 end-page: 33 article-title: Genetic susceptibility to SLE: recent progress from GWAS publication-title: J Autoimmun – volume: 32 start-page: 189 year: 2009 end-page: 94 article-title: MicroRNA in autoimmunity and autoimmune diseases publication-title: J Autoimmun – volume: 7 start-page: e33387 year: 2012 article-title: Proof of concept of microbiome‐metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at‐risk infants publication-title: PLoS ONE – volume: 89 start-page: 90 year: 2014 end-page: 5 article-title: Epstein‐Barr virus in multiple sclerosis publication-title: J Egypt Public Health Assoc – volume: 17 start-page: 393 year: 1997 end-page: 8 article-title: Positional cloning of the APECED gene publication-title: Nat Genet – volume: 98 start-page: 3988 year: 2001 end-page: 91 article-title: Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase publication-title: Proc Natl Acad Sci USA – volume: 146 start-page: 34 year: 2013 end-page: 45 article-title: The role of B lymphocytes in the progression from autoimmunity to autoimmune disease publication-title: Clin Immunol – volume: 51 start-page: 17 year: 2014 end-page: 22 article-title: Infection and autoimmunity in Sjogren's syndrome: a clinical study and comprehensive review publication-title: J Autoimmun – volume: 7 start-page: 8542 year: 2014 end-page: 52 article-title: miR‐29a promotes intestinal epithelial apoptosis in ulcerative colitis by down‐regulating Mcl‐1 publication-title: Int J Clin Exp Pathol – volume: 13 start-page: 463 year: 2014 end-page: 6 article-title: Diagnosis and classification of ulcerative colitis publication-title: Autoimmun Rev – volume: 7 start-page: e36278 year: 2012 article-title: Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes publication-title: PLoS ONE – volume: 51 start-page: 1 year: 2014 end-page: 9 article-title: Sjogren's syndrome: a forty‐year scientific journey publication-title: J Autoimmun – volume: 13 start-page: 408 year: 2014 end-page: 11 article-title: Diagnosis and classification of Addison's disease (autoimmune adrenalitis) publication-title: Autoimmun Rev – volume: 10 start-page: 602 year: 2014 end-page: 11 article-title: PTPN22: the archetypal non‐HLA autoimmunity gene publication-title: Nat Rev Rheumatol – volume: 48–49 start-page: 122 year: 2014 end-page: 7 article-title: The clinical features, diagnosis and classification of dermatomyositis publication-title: J Autoimmun – volume: 8 start-page: 87 year: 2014 end-page: 100 article-title: Rituximab for the treatment of rheumatoid arthritis: an update publication-title: Drug Des Devel Ther – volume: 48–49 start-page: 34 year: 2014 end-page: 7 article-title: Diagnosis and classification of adult Still's disease publication-title: J Autoimmun – volume: 132 start-page: 1112 year: 2013 end-page: 22 article-title: Genetic and epigenetic factors in etiology of diabetes mellitus type 1 publication-title: Pediatrics – volume: 32 start-page: 193 year: 2012 end-page: 285 article-title: Non‐MHC genes linked to autoimmune disease publication-title: Crit Rev Immunol – year: 2014 article-title: Role of genetic and non‐genetic factors in the etiology of Graves' disease publication-title: J Endocrinol Invest – volume: 8 start-page: 919 year: 2008 end-page: 26 article-title: Azathioprine in multiple sclerosis publication-title: Mini Rev Med Chem – volume: 37 start-page: 242 year: 2011 end-page: 53 article-title: Epitope spreading of the anti‐CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model publication-title: J Autoimmun – volume: 24 start-page: 274 year: 2015 end-page: 84 article-title: Meta‐analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus publication-title: Hum Mol Genet – volume: 18 start-page: 1118 year: 2003 end-page: 28 article-title: Epidemiology of autoimmune liver disease publication-title: J Gastroenterol Hepatol – volume: 382 start-page: 819 year: 2013 end-page: 31 article-title: Immunopathogenic mechanisms of systemic autoimmune disease publication-title: Lancet – volume: 11 start-page: 125 year: 2012 end-page: 31 article-title: Association of polymorphisms in non‐classic MHC genes with susceptibility to autoimmune hepatitis publication-title: Hepatobiliary Pancreat Dis Int – volume: 53 start-page: 105 year: 2014 end-page: 14 article-title: PTPN2 restrains CD8(+) T cell responses after antigen cross‐presentation for the maintenance of peripheral tolerance in mice publication-title: J Autoimmun – volume: 24 start-page: 656 year: 2006 end-page: 63 article-title: Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs publication-title: Clin Exp Rheumatol – volume: 33 start-page: 1507 year: 2015 end-page: 14 article-title: Safety of vaccine adjuvants: focus on autoimmunity publication-title: Vaccine – volume: 32 start-page: 761 year: 2014 end-page: 2 article-title: Discovery and validation of novel microRNAs in Sjogren's syndrome salivary glands publication-title: Clin Exp Rheumatol – volume: 2013 start-page: 535738 year: 2013 article-title: Epstein‐Barr virus in systemic autoimmune diseases publication-title: Clin Dev Immunol – volume: 8 start-page: 303 year: 2013 end-page: 30 article-title: The immunobiology and pathophysiology of primary biliary cirrhosis publication-title: Annu Rev Pathol – volume: 7 start-page: e1002216 year: 2011 article-title: Genome‐wide association analysis of autoantibody positivity in type 1 diabetes cases publication-title: PLoS Genet – volume: 8 start-page: 337 year: 2012 end-page: 47 article-title: Follicular helper T cells in immunity and systemic autoimmunity publication-title: Nat Rev Rheumatol – volume: 41 start-page: 79 year: 2013 end-page: 86 article-title: Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA publication-title: J Autoimmun – volume: 52 start-page: 189 year: 2014 end-page: 91 article-title: The role of heavy metals in autoimmunity publication-title: Rom J Intern Med – volume: 36 start-page: 553 year: 2014 end-page: 68 article-title: Mechanisms of tissue injury in autoimmune liver diseases publication-title: Semin Immunopathol – volume: 2 start-page: 1 year: 2008 end-page: 23 article-title: European evidence‐based Consensus on the diagnosis and management of ulcerative colitis: definitions and diagnosis publication-title: J Crohns Colitis – volume: 73 start-page: 1151 year: 2014 end-page: 6 article-title: Primary Sjogren's syndrome and malignancy risk: a systematic review and meta‐analysis publication-title: Ann Rheum Dis – volume: 2 start-page: e01202 year: 2013 article-title: Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis publication-title: eLife – volume: 26 start-page: 85 year: 2014 end-page: 92 article-title: Genome‐wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges publication-title: Curr Opin Rheumatol – volume: 45 start-page: 187 year: 2006 end-page: 91 article-title: Epidemiology of primary Sjogren's syndrome in north‐west Greece, 1982–2003 publication-title: Rheumatology – volume: 48 start-page: 169 year: 2008 end-page: 76 article-title: Simplified criteria for the diagnosis of autoimmune hepatitis publication-title: Hepatology – volume: 157 start-page: 1 year: 2015 end-page: 15 article-title: Epigenetic control of autoimmune diseases: from bench to bedside publication-title: Clin Immunol – volume: 48–49 start-page: 76 year: 2014 end-page: 8 article-title: Polymyalgia rheumatica–diagnosis and classification publication-title: J Autoimmun – volume: 50 start-page: 291 year: 2009 end-page: 308 article-title: Primary biliary cirrhosis publication-title: Hepatology – volume: 42 start-page: 295 year: 2010 end-page: 302 article-title: Multiple common variants for celiac disease influencing immune gene expression publication-title: Nat Genet – volume: 60 start-page: 1708 year: 2014 end-page: 16 article-title: Ongoing activation of autoantigen‐specific B cells in primary biliary cirrhosis publication-title: Hepatology – volume: 164 start-page: 231 year: 2014 end-page: 6 article-title: Methotrexate: new uses for an old drug publication-title: J Pediatr – volume: 154 start-page: 3173 year: 1995 end-page: 9 article-title: Complement activation by cross‐linked B cell‐membrane IgM publication-title: J Immunol – volume: 69 start-page: 1580 year: 2010 end-page: 8 article-title: 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative publication-title: Ann Rheum Dis – volume: 59 start-page: 2890 year: 2014 end-page: 904 article-title: Targeting apoptosis in autoimmune hepatitis publication-title: Dig Dis Sci – volume: 71 start-page: 1033 year: 2008 end-page: 5 article-title: Broadened and elevated humoral immune response to EBNA1 in pediatric multiple sclerosis publication-title: Neurology – volume: 6 start-page: 639 year: 2005 article-title: Paul Ehrlich, archives and the history of immunology publication-title: Nat Immunol – volume: 194 start-page: 13 year: 2015 end-page: 20 article-title: Natural antibodies bridge innate and adaptive immunity publication-title: J Immunol – volume: 164 start-page: 53 year: 1998 end-page: 61 article-title: Shifting T‐cell activation thresholds in autoimmunity and determinant spreading publication-title: Immunol Rev – volume: 31 start-page: 257 year: 2008 end-page: 62 article-title: The consequences of apoptosis in autoimmunity publication-title: J Autoimmun – volume: 7 start-page: R503 year: 2005 end-page: 12 article-title: Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption publication-title: Arthritis Res Ther – volume: 348 start-page: 719 year: 1996 end-page: 23 article-title: Clinical, immunological, and pathological consequences of Fas‐deficient conditions publication-title: Lancet – volume: 429 start-page: 566 year: 2004 end-page: 71 article-title: The transcriptional programme of antibody class switching involves the repressor Bach2 publication-title: Nature – volume: 30 start-page: 154 year: 2014 end-page: 62 article-title: Advances in coeliac disease publication-title: Curr Opin Gastroenterol – volume: 365 start-page: 1612 year: 2011 end-page: 23 article-title: Genomics and the multifactorial nature of human autoimmune disease publication-title: N Engl J Med – volume: 48–49 start-page: 20 year: 2014 end-page: 5 article-title: Diagnosis and classification of the antiphospholipid syndrome publication-title: J Autoimmun – volume: 34 start-page: 329 year: 2014 end-page: 33 article-title: The natural history of primary biliary cirrhosis publication-title: Semin Liver Dis – volume: 50 start-page: 33 year: 2014 end-page: 7 article-title: DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology publication-title: J Autoimmun – volume: 64 start-page: 504 year: 2015 end-page: 13 article-title: MicroRNAs: new players in IBD publication-title: Gut – volume: 25 start-page: 1828 year: 2013 end-page: 36 article-title: The emerging role of microRNAs in the pathogenesis of systemic lupus erythematosus publication-title: Cell Signal – volume: 322 start-page: 1829 year: 1990 end-page: 36 article-title: Clinical variation of autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy (APECED) in a series of 68 patients publication-title: N Engl J Med – volume: 57 start-page: 53 year: 2015 end-page: 9 article-title: The amino acid variation within the binding pocket 7 and 9 of HLA‐DRB1 molecules are associated with primary Sjogren's syndrome publication-title: J Autoimmun – volume: 23 start-page: 1298 year: 2014 end-page: 310 article-title: Coregulation and modulation of NFkappaB‐related genes in celiac disease: uncovered aspects of gut mucosal inflammation publication-title: Hum Mol Genet – volume: 2 start-page: 85 year: 2002 end-page: 95 article-title: Epitope spreading in immune‐mediated diseases: implications for immunotherapy publication-title: Nat Rev Immunol – volume: 53 start-page: 1367 year: 1999 end-page: 8 article-title: Absence of human herpesvirus 6 and 7 from spinal fluid and serum of multiple sclerosis patients publication-title: Neurology – volume: 23 start-page: 213 year: 2014 end-page: 9 article-title: The prevalence and incidence of systemic lupus erythematosus (SLE) in selected cities from three Commonwealth of Independent States countries (the Russian Federation, Ukraine and Kazakhstan) publication-title: Lupus – volume: 2012 start-page: 593720 year: 2012 article-title: Epigenetics and autoimmune diseases publication-title: Autoimmune Dis – volume: 16 start-page: 1766 year: 2012 end-page: 75 article-title: TNF‐alpha inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation publication-title: J Cell Mol Med – volume: 13 start-page: 467 year: 2014 end-page: 71 article-title: Diagnosis and classification of Crohn's disease publication-title: Autoimmun Rev – volume: 14 start-page: 211 year: 2012 article-title: The genetics of lupus: a functional perspective publication-title: Arthritis Res Ther – volume: 11 start-page: 307 year: 2015 end-page: 16 article-title: Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy publication-title: Expert Opin Drug Metab Toxicol – volume: 11 start-page: 375 year: 2015 end-page: 9 article-title: Genetics of rheumatoid arthritis in Asia‐present and future publication-title: Nat Rev Rheumatol – volume: 15 start-page: 1575 year: 2014 end-page: 83 article-title: Glucocorticoid treatment in rheumatoid arthritis publication-title: Expert Opin Pharmacother – volume: 71 start-page: 682 year: 2008 end-page: 9 article-title: The MSMV hypothesis: measles virus and multiple sclerosis, etiology and treatment publication-title: Med Hypotheses – volume: 64 start-page: 406 year: 2015 end-page: 17 article-title: The HLA‐DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease publication-title: Gut – volume: 34 start-page: 275 year: 1997 end-page: 311 article-title: Current concepts and advances in clinical laboratory testing for autoimmune diseases publication-title: Crit Rev Clin Lab Sci – volume: 299 start-page: 1259 year: 1989 end-page: 60 article-title: Hay fever, hygiene, and household size publication-title: BMJ – volume: 366 start-page: 321 year: 2005 end-page: 31 article-title: Sjogren's syndrome publication-title: Lancet – volume: 40 start-page: 1399 year: 2008 end-page: 401 article-title: Meta‐analysis of genome‐wide association study data identifies additional type 1 diabetes risk loci publication-title: Nat Genet – volume: 175 start-page: 408 year: 2014 end-page: 18 article-title: Myasthenia gravis: an update for the clinician publication-title: Clin Exp Immunol – volume: 9 start-page: 10 year: 2015 end-page: 9 article-title: Th17 cells in autoimmune diseases publication-title: Front Med – volume: 109 start-page: 757 year: 2014 end-page: 68 article-title: Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population‐based study publication-title: Am J Gastroenterol – volume: 6 start-page: 345 year: 2005 end-page: 52 article-title: Naturally arising Foxp3‐expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non‐self publication-title: Nat Immunol – volume: 93 start-page: e309 year: 2014 article-title: DNA methylation profile of genes involved in inflammation and autoimmunity in inflammatory bowel disease publication-title: Medicine – volume: 105 start-page: 204 year: 2015 end-page: 10 article-title: Genome‐wide DNA methylation analysis in Graves' disease publication-title: Genomics – volume: 498 start-page: 506 year: 2013 end-page: 10 article-title: BACH2 represses effector programs to stabilize T(reg)‐mediated immune homeostasis publication-title: Nature – volume: 14 start-page: 407 year: 2014 article-title: Complexities in the relationship between infection and autoimmunity publication-title: Curr Allergy Asthma Rep – volume: 34 start-page: 318 year: 2014 end-page: 28 article-title: The new epidemiology of primary biliary cirrhosis publication-title: Semin Liver Dis – volume: 31 start-page: 929 year: 1999 end-page: 38 article-title: International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis publication-title: J Hepatol – volume: 20 start-page: 639 year: 2014 end-page: 43 article-title: Increased microRNA‐155 and decreased microRNA‐146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy publication-title: Med Sci Monit – volume: 13 start-page: 202 year: 2011 article-title: Disturbances of apoptotic cell clearance in systemic lupus erythematosus publication-title: Arthritis Res Ther – volume: 382 start-page: 1433 year: 2013 end-page: 44 article-title: Autoimmune hepatitis publication-title: Lancet – volume: 45 start-page: 1284 year: 2013 end-page: 92 article-title: Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome publication-title: Nat Genet – volume: 36 start-page: 491 year: 2014 end-page: 3 article-title: Introduction: mechanisms of tissue injury in autoimmune diseases publication-title: Semin Immunopathol – volume: 361 start-page: 1881 year: 2003 end-page: 93 article-title: Adrenal insufficiency publication-title: Lancet – volume: 48–49 start-page: 134 year: 2014 end-page: 42 article-title: The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review publication-title: J Autoimmun – volume: 39 start-page: 696 year: 2014 end-page: 707 article-title: Systematic review and meta‐analysis of ustekinumab for moderate to severe psoriasis publication-title: Clin Exp Dermatol – volume: 14 start-page: 462 year: 2014 article-title: Autoimmune lymphoproliferative syndrome: an update and review of the literature publication-title: Curr Allergy Asthma Rep – volume: 61 start-page: 1087 year: 2014 end-page: 92 article-title: Circulating levels of miR‐146a and IL‐17 are significantly correlated with the clinical activity of Graves' ophthalmopathy publication-title: Endocr J – volume: 44 start-page: 1122 year: 2001 end-page: 6 article-title: Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure publication-title: Arthritis Rheum – volume: 8 start-page: 137 year: 2013 end-page: 46 article-title: Cytomegalovirus infection in childhood‐onset systemic lupus erythematosus publication-title: Int J Clin Rheumatol – volume: 177 start-page: 30 year: 2014 end-page: 7 article-title: The intestinal microbiome in type 1 diabetes publication-title: Clin Exp Immunol – volume: 52 start-page: 1160 year: 2005 end-page: 70 article-title: Generation of novel covalent RNA‐protein complexes in cells by ultraviolet B irradiation: implications for autoimmunity publication-title: Arthritis Rheum – volume: 64 start-page: 428 year: 2015 end-page: 37 article-title: Diet‐induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease‐associated colonisation publication-title: Gut – volume: 353 start-page: 1261 year: 2005 end-page: 73 article-title: Primary biliary cirrhosis publication-title: N Engl J Med – volume: 28 start-page: 97 year: 2006 end-page: 107 article-title: Current topics in human SLE genetics publication-title: Springer Semin Immunopathol – volume: 171 start-page: 5778 year: 2003 end-page: 86 article-title: Ultraviolet B radiation‐induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution publication-title: J Immunol – volume: 48–49 start-page: 128 year: 2014 end-page: 33 article-title: The classification and diagnostic criteria of ankylosing spondylitis publication-title: J Autoimmun – volume: 48–49 start-page: 60 year: 2014 end-page: 5 article-title: International consensus criteria for the diagnosis of Raynaud's phenomenon publication-title: J Autoimmun – volume: 30 start-page: 409 year: 2009 end-page: 14 article-title: Infections and autoimmunity–friends or foes? publication-title: Trends Immunol – volume: 29 start-page: 1 year: 2007 end-page: 9 article-title: Epidemiology of autoimmune diseases in Denmark publication-title: J Autoimmun – volume: 12 start-page: 127 year: 2012 end-page: 36 article-title: Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature publication-title: Autoimmun Rev – volume: 34 start-page: 341 year: 2014 end-page: 5 article-title: Smoking, disease activity, permanent damage and dsDNA autoantibody production in patients with systemic lupus erythematosus publication-title: Rheumatol Int – volume: 45 start-page: 599 year: 2013 end-page: 604 article-title: MicroRNA expressions in PMBCs, CD4+, and CD8+ T‐cells from patients suffering from autoimmune Addison's disease publication-title: Horm Metab Res – volume: 48–49 start-page: 10 year: 2014 end-page: 3 article-title: Diagnostic criteria for systemic lupus erythematosus: a critical review publication-title: J Autoimmun – volume: 49 start-page: 2172 year: 2010 end-page: 80 article-title: Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solvents publication-title: Rheumatology – volume: 39 start-page: 63 year: 2006 end-page: 70 article-title: Epstein‐Barr virus and molecular mimicry in systemic lupus erythematosus publication-title: Autoimmunity – volume: 33 start-page: 993 year: 1990 end-page: 1000 article-title: Altered immune response to glycine‐rich sequences of Epstein‐Barr nuclear antigen‐1 in patients with rheumatoid arthritis and systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 33 start-page: S62 issue: Suppl 1 year: 2010 end-page: 9 article-title: Diagnosis and classification of diabetes mellitus publication-title: Diabetes Care – volume: 30 start-page: 5 year: 2008 end-page: 11 article-title: Cell damage and autoimmunity: a critical appraisal publication-title: J Autoimmun – volume: 42 start-page: 7 year: 2013 end-page: 18 article-title: Sjogren's syndrome and the epithelial target: a comprehensive review publication-title: J Autoimmun – volume: 41 start-page: 50 year: 2013 end-page: 9 article-title: DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF‐7 binding activity in fulminant type 1 diabetes publication-title: J Autoimmun – volume: 184 start-page: 2204 year: 2010 end-page: 10 article-title: Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens publication-title: J Immunol – volume: 4 start-page: 7 year: 2010 end-page: 27 article-title: The second European evidence‐based Consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis publication-title: J Crohns Colitis – volume: 9 start-page: 1131 year: 2014 end-page: 7 article-title: DNA methylation‐associated colonic mucosal immune and defense responses in treatment‐naive pediatric ulcerative colitis publication-title: Epigenetics – volume: 20 start-page: 263 year: 2015 end-page: 72 article-title: How apoptotic beta‐cells direct immune response to tolerance or to autoimmune diabetes: a review publication-title: Apoptosis – volume: 18 start-page: 273 year: 2014 end-page: 82 article-title: Enterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes publication-title: Discov Med – volume: 81 start-page: 2595 year: 1996 end-page: 600 article-title: Antibody‐dependent cell‐mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies publication-title: J Clin Endocrinol Metab – volume: 15 start-page: 430 year: 2003 end-page: 5 article-title: Immune dysregulation, polyendocrinopathy, enteropathy, and X‐linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T‐cell homeostasis publication-title: Curr Opin Rheumatol – volume: 358 start-page: 155 year: 1992 end-page: 7 article-title: Spreading of T‐cell autoimmunity to cryptic determinants of an autoantigen publication-title: Nature – volume: 66 start-page: S116 year: 2008 end-page: 24 article-title: Vitamin D's role in cell proliferation and differentiation publication-title: Nutr Rev – volume: 65 start-page: 909 year: 1990 end-page: 11 article-title: Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition publication-title: Arch Dis Child – volume: 38 start-page: J156 year: 2012 end-page: 69 article-title: Twin studies in autoimmune disease: genetics, gender and environment publication-title: J Autoimmun – volume: 75 start-page: 268 year: 2014 end-page: 70 article-title: Diagnosing coeliac disease in children publication-title: Br J Hosp Med – volume: 23 start-page: 857 year: 2006 end-page: 66 article-title: Incidence and trends of childhood Type 1 diabetes worldwide 1990‐1999 publication-title: Diabet Med – volume: 333 start-page: 958 year: 1995 end-page: 63 article-title: Azathioprine for long‐term maintenance of remission in autoimmune hepatitis publication-title: N Engl J Med – volume: 73 start-page: 1423 year: 2014 end-page: 6 article-title: Smoking induces transcription of the heat shock protein system in the joints publication-title: Ann Rheum Dis – volume: 14 start-page: 555 year: 2015 end-page: 63 article-title: Autoantibodies 2015: from diagnostic biomarkers toward prediction, prognosis and prevention publication-title: Autoimmun Rev – volume: 34 start-page: 297 year: 2014 end-page: 317 article-title: Breach of tolerance: primary biliary cirrhosis publication-title: Semin Liver Dis – volume: 12 start-page: 726 year: 2013 end-page: 40 article-title: Infectome: a platform to trace infectious triggers of autoimmunity publication-title: Autoimmun Rev – volume: 18 start-page: 649 year: 2012 end-page: 56 article-title: Differences of small intestinal bacteria populations in adults and children with/without celiac disease: effect of age, gluten diet, and disease publication-title: Inflamm Bowel Dis – volume: 48–49 start-page: 26 year: 2014 end-page: 30 article-title: Diagnosis and classification of rheumatoid arthritis publication-title: J Autoimmun – volume: 44 start-page: 676 year: 2012 end-page: 80 article-title: Genome‐wide association analyses identify 13 new susceptibility loci for generalized vitiligo publication-title: Nat Genet – volume: 10 start-page: 89 year: 2009 end-page: 116 article-title: The genetics of Crohn's disease publication-title: Annu Rev Genomics Hum Genet – volume: 46 start-page: 128 year: 2013 end-page: 37 article-title: Hormones and AID: balancing immunity and autoimmunity publication-title: Autoimmunity – volume: 41 start-page: 46 year: 2013 end-page: 9 article-title: Natural autoantibodies in the physiology and pathophysiology of the immune system publication-title: J Autoimmun – volume: 45 start-page: 256 year: 2013 end-page: 66 article-title: Vitamin D in systemic and organ‐specific autoimmune diseases publication-title: Clin Rev Allergy Immunol – volume: 9 start-page: 147 year: 2014 end-page: 56 article-title: Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics publication-title: Annu Rev Pathol – volume: 38 start-page: J71 year: 2012 end-page: 3 article-title: Sex gender and autoimmunity publication-title: J Autoimmun – volume: 12 start-page: 111 year: 2011 article-title: Genome‐wide copy number variation (CNV) in patients with autoimmune Addison's disease publication-title: BMC Med Genet – volume: 66 start-page: 340 year: 2002 end-page: 50 article-title: Enterovirus infection can induce immune responses that cross‐react with beta‐cell autoantigen tyrosine phosphatase IA‐2/IAR publication-title: J Med Virol – volume: 5 start-page: 164 year: 2014 article-title: Breaking immunological tolerance in systemic lupus erythematosus publication-title: Front Immunol – volume: 9 start-page: 243 year: 1991 end-page: 69 article-title: Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease publication-title: Annu Rev Immunol – volume: 345 start-page: 340 year: 2001 end-page: 50 article-title: Autoimmune diseases publication-title: N Engl J Med – volume: 48–49 start-page: 149 year: 2014 end-page: 52 article-title: Diagnosis and classification of central nervous system vasculitis publication-title: J Autoimmun – volume: 25 start-page: 265 year: 2005 end-page: 80 article-title: Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology publication-title: Semin Liver Dis – volume: 35 start-page: 804 year: 2008 end-page: 10 article-title: Abnormal histone modification patterns in lupus CD4+ T cells publication-title: J Rheumatol – volume: 55 start-page: 153 year: 2012 end-page: 60 article-title: Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis publication-title: Hepatology – volume: 368 start-page: 1528 year: 2013 end-page: 35 article-title: Belimumab for systemic lupus erythematosus publication-title: N Engl J Med – volume: 48–49 start-page: 99 year: 2014 end-page: 103 article-title: Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg‐Strauss syndrome) publication-title: J Autoimmun – volume: 42 start-page: 1118 year: 2010 end-page: 25 article-title: Genome‐wide meta‐analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci publication-title: Nat Genet – volume: 59 start-page: 208 year: 2014 end-page: 16 article-title: Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease publication-title: Mol Immunol – volume: 60 start-page: 1735 year: 2014 end-page: 45 article-title: Relationship between toxic metals exposure via cigarette smoking and rheumatoid arthritis publication-title: Clin Lab – year: 2010 – volume: 51 start-page: 660 year: 2010 end-page: 78 article-title: Diagnosis and management of primary sclerosing cholangitis publication-title: Hepatology – volume: 9 start-page: 646 year: 2013 end-page: 59 article-title: Clinical implications of shared genetics and pathogenesis in autoimmune diseases publication-title: Nat Rev Endocrinol – year: 2014 article-title: Serological markers of enterocyte damage and apoptosis in patients with celiac disease, autoimmune diabetes mellitus and diabetes mellitus type 2 publication-title: Physiol Res – volume: 17 start-page: 659 year: 2013 end-page: 65 article-title: MicroRNA‐21 with therapeutic potential in autoimmune diseases publication-title: Expert Opin Ther Targets – volume: 35 start-page: 1500 year: 2008 end-page: 5 article-title: Fecal microbiota in early rheumatoid arthritis publication-title: J Rheumatol – volume: 18 start-page: 299 year: 2012 end-page: 304 article-title: Methylation‐dependent PAD2 upregulation in multiple sclerosis peripheral blood publication-title: Mult Scler – volume: 5 start-page: 71 year: 2014 article-title: The contribution of epigenetics in Sjogren's Syndrome publication-title: Front Genet – volume: 14 start-page: 105 year: 2015 end-page: 16 article-title: Regulatory T‐cells in autoimmune diseases: challenges, controversies and‐yet‐unanswered questions publication-title: Autoimmun Rev – volume: 32 start-page: 111 year: 2007 end-page: 8 article-title: Molecular mimicry and auto‐immunity publication-title: Clin Rev Allergy Immunol – volume: 9 start-page: A387 year: 2010 end-page: 94 article-title: Multiple sclerosis: geoepidemiology, genetics and the environment publication-title: Autoimmun Rev – volume: 222 start-page: R1 year: 2014 end-page: 10 article-title: Application of microRNAs in diabetes mellitus publication-title: J Endocrinol – volume: 5 start-page: 132 year: 2006 end-page: 5 article-title: A short review of the pathogenesis of Sjogren's syndrome publication-title: Autoimmun Rev – volume: 54 start-page: 127 year: 2014 end-page: 36 article-title: DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype publication-title: J Autoimmun – volume: 106 start-page: 325 year: 2014 end-page: 33 article-title: MicroRNAs: an epigenetic tool to study celiac disease publication-title: Rev Esp Enferm Dig – volume: 34 start-page: 265 year: 2014 end-page: 72 article-title: Environmental factors in primary biliary cirrhosis publication-title: Semin Liver Dis – volume: 122 start-page: 455 year: 2014 end-page: 64 article-title: Glucocorticoid treatment of multiple sclerosis publication-title: Handb Clin Neurol – volume: 64 start-page: 2677 year: 2012 end-page: 86 article-title: Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 63 start-page: 1695 year: 2014 end-page: 9 article-title: Use of azathioprine in IBD: modern aspects of an old drug publication-title: Gut – volume: 31 start-page: 24 year: 2014 end-page: 30 article-title: Molecular mechanisms for contribution of MHC molecules to autoimmune diseases publication-title: Curr Opin Immunol – volume: 1 start-page: 97 year: 2002 end-page: 103 article-title: Iodine: an environmental trigger of thyroiditis publication-title: Autoimmun Rev – year: 2014 article-title: The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012 publication-title: Ann Rheum Dis – volume: 2014 start-page: 527895 year: 2014 article-title: MicroRNAs in autoimmune diseases publication-title: Biomed Res Int – volume: 19 start-page: 488 year: 2014 end-page: 93 article-title: Primary biliary cirrhosis in the era of liver transplantation publication-title: Ann Transplant – volume: 42 start-page: 42 year: 2015 end-page: 60 article-title: Immunogenetics of type 1 diabetes mellitus publication-title: Mol Aspects Med – volume: 357 start-page: 1731 year: 2007 end-page: 43 article-title: Celiac disease publication-title: N Engl J Med – volume: 33 start-page: 314 year: 2014 end-page: 29 article-title: Rheumatic fever, autoimmunity, and molecular mimicry: the streptococcal connection publication-title: Int Rev Immunol – volume: 48–49 start-page: 113 year: 2014 end-page: 7 article-title: Diagnosis and classification of Kawasaki disease publication-title: J Autoimmun – volume: 34 start-page: 255 year: 2014 end-page: 64 article-title: Genetics and epigenetics of primary biliary cirrhosis publication-title: Semin Liver Dis – volume: 4 start-page: 1 year: 2012 end-page: 10 article-title: Epidemiology and treatment of autoimmune hepatitis publication-title: Hepat Med – volume: 452 start-page: 254 year: 2014 end-page: 62 article-title: Genetic basis of rheumatoid arthritis: a current review publication-title: Biochem Biophys Res Commun – volume: 69 start-page: 292 year: 2011 end-page: 302 article-title: Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria publication-title: Ann Neurol – volume: 48–49 start-page: 143 year: 2014 end-page: 8 article-title: Diagnostic and clinical classification of autoimmune myasthenia gravis publication-title: J Autoimmun – volume: 28 start-page: 363 year: 2014 end-page: 72 article-title: Epidemiology of inflammatory bowel disease: focus on Asia publication-title: Best Pract Res Clin Gastroenterol – volume: 170 start-page: 59 year: 1989 end-page: 71 article-title: Self recognition by T cells. I. Bystander killing of target cells bearing syngeneic MHC antigens publication-title: J Exp Med – volume: 9 start-page: A259 year: 2010 end-page: 66 article-title: Definition of human autoimmunity–autoantibodies versus autoimmune disease publication-title: Autoimmun Rev – volume: 39 start-page: 481 year: 2010 end-page: 97 article-title: Epidemiology of type 1 diabetes publication-title: Endocrinol Metab Clin North Am – volume: 38 start-page: 226 year: 2013 end-page: 45 article-title: Systematic review: worldwide variation in the frequency of coeliac disease and changes over time publication-title: Aliment Pharmacol Ther – volume: 122 start-page: 193 year: 2014 end-page: 209 article-title: Multiple sclerosis genetics publication-title: Handb Clin Neurol – volume: 41 start-page: 1 year: 2013 end-page: 5 article-title: The critical importance of epigenetics in autoimmunity publication-title: J Autoimmun – volume: 34 start-page: 466 year: 2015 end-page: 74 article-title: Commensal microbiota influence systemic autoimmune responses publication-title: EMBO J – volume: 198 start-page: 1147 year: 2003 end-page: 56 article-title: Molecular mimicry between Helicobacter pylori antigens and H+, K+ –adenosine triphosphatase in human gastric autoimmunity publication-title: J Exp Med – volume: 52 start-page: 987 year: 2010 end-page: 98 article-title: Biliary apotopes and anti‐mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis publication-title: Hepatology – volume: 33 start-page: 1525 year: 2013 end-page: 32 article-title: Prevalence and incidence of rheumatoid arthritis in South Korea publication-title: Rheumatol Int – volume: 69 start-page: 2062 year: 2010 end-page: 6 article-title: Prevention of autoimmune rheumatic disease: state of the art and future perspectives publication-title: Ann Rheum Dis – volume: 384 start-page: 1878 year: 2014 end-page: 88 article-title: Systemic lupus erythematosus publication-title: Lancet – volume: 15 start-page: 372 year: 2013 article-title: Epigenetics in rheumatoid arthritis: a primer for rheumatologists publication-title: Curr Rheumatol Rep – volume: 11 start-page: 80 year: 2014 end-page: 2 article-title: Coeliac disease in 2013: new insights in dietary‐gluten‐induced autoimmunity publication-title: Nat Rev Gastroenterol Hepatol – volume: 51 start-page: 10 year: 2014 end-page: 6 article-title: Sjogren's syndrome: another facet of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) publication-title: J Autoimmun – volume: 6 start-page: 325 year: 2007 end-page: 33 article-title: Autoantibodies as predictors of disease: the clinical and experimental evidence publication-title: Autoimmun Rev – volume: 39 start-page: 257 year: 2010 end-page: 68 article-title: Understanding the epidemiology and progression of systemic lupus erythematosus publication-title: Semin Arthritis Rheum – volume: 64 start-page: 475 year: 2012 end-page: 87 article-title: American College of Rheumatology classification criteria for Sjogren's syndrome: a data‐driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort publication-title: Arthritis Care Res – volume: 69 start-page: 5345 year: 2001 end-page: 51 article-title: T‐cell reactivity against streptococcal antigens in the periphery mirrors reactivity of heart‐infiltrating T lymphocytes in rheumatic heart disease patients publication-title: Infect Immun – volume: 131 start-page: 606 year: 2006 end-page: 18 article-title: Autoreactive T‐cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory publication-title: Gastroenterology – volume: 26 start-page: 482 year: 2014 end-page: 92 article-title: Advances in lupus genetics and epigenetics publication-title: Curr Opin Rheumatol – volume: 53 start-page: 85 year: 2014 end-page: 94 article-title: Long term effect of gut microbiota transfer on diabetes development publication-title: J Autoimmun – volume: 10 start-page: 175 year: 2010 article-title: A distinctive ‘microbial signature’ in celiac pediatric patients publication-title: BMC Microbiol – volume: 365 start-page: 2205 year: 2011 end-page: 19 article-title: The pathogenesis of rheumatoid arthritis publication-title: N Engl J Med – volume: 43 start-page: 18 year: 2013 end-page: 25 article-title: Immunization of mice with a newly identified thyroid‐stimulating hormone receptor splice variant induces Graves'‐like disease publication-title: J Autoimmun – volume: 48–49 start-page: 84 year: 2014 end-page: 9 article-title: Diagnosis and classification of polyarteritis nodosa publication-title: J Autoimmun – volume: 25 start-page: 1075 year: 2011 end-page: 86 article-title: Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms publication-title: Mol Endocrinol – volume: 246 start-page: 51 year: 2012 end-page: 7 article-title: Increased promoter methylation of the immune regulatory gene SHP‐1 in leukocytes of multiple sclerosis subjects publication-title: J Neuroimmunol – volume: 76 start-page: 417 year: 1956 end-page: 27 article-title: Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts publication-title: J Immunol – volume: 476 start-page: 214 year: 2011 end-page: 9 article-title: Genetic risk and a primary role for cell‐mediated immune mechanisms in multiple sclerosis publication-title: Nature – volume: 15 start-page: 1171 year: 2014 end-page: 80 article-title: The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program publication-title: Nat Immunol – volume: 60 start-page: 1314 year: 2014 end-page: 23 article-title: Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells publication-title: Hepatology – volume: 165 start-page: 270 year: 2015 end-page: 82 article-title: Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases publication-title: Transl Res – volume: 41 start-page: 126 year: 2013 end-page: 39 article-title: Autoimmune hepatitis: a comprehensive review publication-title: J Autoimmun – volume: 142 start-page: 46 year: 2012 end-page: 54 article-title: Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review publication-title: Gastroenterology – volume: 73 start-page: 1316 year: 2014 end-page: 22 article-title: The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study publication-title: Ann Rheum Dis – volume: 42 start-page: 252 year: 2012 end-page: 65 article-title: The incidence and prevalence of thyroid autoimmunity publication-title: Endocrine – volume: 24 start-page: 571 year: 2012 end-page: 5 article-title: What have we learned from six years of GWAS in autoimmune diseases, and what is next? publication-title: Curr Opin Immunol – volume: 48–49 start-page: 14 year: 2014 end-page: 9 article-title: The classification and diagnosis of cutaneous lupus erythematosus publication-title: J Autoimmun – volume: 84 start-page: 223 year: 1997 end-page: 43 article-title: Epidemiology and estimated population burden of selected autoimmune diseases in the United States publication-title: Clin Immunol Immunopathol – volume: 34 start-page: J258 year: 2010 end-page: 65 article-title: Effects of tobacco smoke on immunity, inflammation and autoimmunity publication-title: J Autoimmun – volume: 17 start-page: 609 year: 2005 end-page: 15 article-title: Monogenic autoimmune diseases – lessons of self‐tolerance publication-title: Curr Opin Immunol – volume: 24 start-page: 582 year: 2015 end-page: 96 article-title: The IRF5‐TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share publication-title: Hum Mol Genet – volume: 43 start-page: 792 year: 2014 end-page: 7 article-title: miR‐146a and miR‐155 expression in PBMCs from patients with Sjogren's syndrome publication-title: J Oral Pathol Med – volume: 349 start-page: 1907 year: 2003 end-page: 15 article-title: Treatment of rheumatoid arthritis by selective inhibition of T‐cell activation with fusion protein CTLA4Ig publication-title: N Engl J Med – volume: 48–49 start-page: 50 year: 2014 end-page: 2 article-title: The diagnosis and classification of undifferentiated connective tissue diseases publication-title: J Autoimmun – volume: 27 start-page: 751 year: 1992 end-page: 8 article-title: Increased expression of Epstein‐Barr virus in primary biliary cirrhosis patients publication-title: Gastroenterol Jpn – volume: 41 start-page: 60 year: 2013 end-page: 71 article-title: Overexpression of X‐linked genes in T cells from women with lupus publication-title: J Autoimmun – volume: 45 start-page: 395 year: 1999 end-page: 401 article-title: HLA‐DR and ‐DQ phenotypes in inflammatory bowel disease: a meta‐analysis publication-title: Gut – volume: 350 start-page: 2572 year: 2004 end-page: 81 article-title: Efficacy of B‐cell‐targeted therapy with rituximab in patients with rheumatoid arthritis publication-title: N Engl J Med – volume: 20 start-page: 1784 year: 2014 end-page: 93 article-title: Two‐stage genome‐wide methylation profiling in childhood‐onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci publication-title: Inflamm Bowel Dis – volume: 36 start-page: 1004 year: 2009 end-page: 10 article-title: Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients publication-title: J Clin Periodontol – volume: 13 start-page: 700 year: 2014 end-page: 9 article-title: Multiple sclerosis genetics publication-title: Lancet Neurol – volume: 13 start-page: 398 year: 2014 end-page: 402 article-title: Diagnosis and classification of Graves' disease publication-title: Autoimmun Rev – volume: 35 start-page: 10 year: 2010 end-page: 4 article-title: The environment, geo‐epidemiology, and autoimmune disease: rheumatoid arthritis publication-title: J Autoimmun – ident: e_1_2_11_6_1 doi: 10.1016/j.clim.2012.10.005 – ident: e_1_2_11_36_1 doi: 10.1038/nature02596 – ident: e_1_2_11_44_1 doi: 10.1038/ng.2272 – ident: e_1_2_11_227_1 doi: 10.1002/art.20992 – ident: e_1_2_11_111_1 doi: 10.1210/jc.81.7.2595 – volume: 35 start-page: 1500 year: 2008 ident: e_1_2_11_86_1 article-title: Fecal microbiota in early rheumatoid arthritis publication-title: J Rheumatol – volume: 52 start-page: 189 year: 2014 ident: e_1_2_11_232_1 article-title: The role of heavy metals in autoimmunity publication-title: Rom J Intern Med – ident: e_1_2_11_93_1 doi: 10.1111/j.1753-4887.2008.00094.x – ident: e_1_2_11_184_1 doi: 10.1507/endocrj.EJ14-0246 – ident: e_1_2_11_141_1 doi: 10.1053/j.gastro.2006.05.056 – ident: e_1_2_11_31_1 doi: 10.1615/CritRevImmunol.v32.i3.10 – ident: e_1_2_11_56_1 doi: 10.1016/j.jaut.2009.02.012 – ident: e_1_2_11_22_1 doi: 10.1038/ng1297-393 – ident: e_1_2_11_149_1 doi: 10.1056/NEJMra043898 – ident: e_1_2_11_94_1 doi: 10.1007/s12016-012-8342-y – ident: e_1_2_11_37_1 doi: 10.1038/ni.3024 – ident: e_1_2_11_3_1 doi: 10.1055/s-0034-1383729 – ident: e_1_2_11_105_1 doi: 10.1002/hep.23783 – ident: e_1_2_11_81_1 doi: 10.1002/ibd.21830 – ident: e_1_2_11_238_1 doi: 10.1002/hep.23294 – ident: e_1_2_11_66_1 doi: 10.1002/1529-0131(200105)44:5<1122::AID-ANR193>3.0.CO;2-D – ident: e_1_2_11_20_1 doi: 10.1016/j.jaut.2013.02.001 – ident: e_1_2_11_154_1 doi: 10.1016/j.jaut.2012.11.002 – ident: e_1_2_11_72_1 doi: 10.1084/jem.170.1.59 – ident: e_1_2_11_161_1 doi: 10.1016/j.autrev.2014.01.028 – ident: e_1_2_11_112_1 doi: 10.1016/j.autrev.2009.12.002 – ident: e_1_2_11_34_1 doi: 10.1016/j.jaut.2014.05.008 – ident: e_1_2_11_173_1 doi: 10.1016/j.jaut.2009.12.009 – ident: e_1_2_11_191_1 doi: 10.1136/gutjnl-2014-306944 – ident: e_1_2_11_212_1 doi: 10.1007/s00281-006-0031-6 – ident: e_1_2_11_177_1 doi: 10.1016/j.mam.2014.12.004 – ident: e_1_2_11_45_1 doi: 10.1038/nrendo.2013.161 – ident: e_1_2_11_59_1 doi: 10.1016/j.jaut.2014.02.008 – ident: e_1_2_11_208_1 doi: 10.1186/ar3844 – ident: e_1_2_11_24_1 doi: 10.1007/s11882-014-0462-4 – ident: e_1_2_11_67_1 doi: 10.1212/WNL.53.6.1367-a – ident: e_1_2_11_139_1 doi: 10.1007/s00281-014-0446-4 – ident: e_1_2_11_39_1 doi: 10.1371/journal.pgen.1002216 – ident: e_1_2_11_83_1 doi: 10.1186/1471-2180-10-175 – ident: e_1_2_11_14_1 doi: 10.1038/ajg.2014.55 – ident: e_1_2_11_175_1 doi: 10.1016/B978-0-444-52001-2.00009-1 – ident: e_1_2_11_26_1 doi: 10.1038/ni1178 – ident: e_1_2_11_163_1 doi: 10.12968/hmed.2014.75.5.268 – ident: e_1_2_11_108_1 doi: 10.1007/s10620-014-3284-2 – ident: e_1_2_11_69_1 doi: 10.1038/nri724 – volume: 4 start-page: 1 year: 2012 ident: e_1_2_11_155_1 article-title: Epidemiology and treatment of autoimmune hepatitis publication-title: Hepat Med – ident: e_1_2_11_71_1 doi: 10.1038/358155a0 – ident: e_1_2_11_217_1 doi: 10.1002/jmv.2151 – ident: e_1_2_11_188_1 doi: 10.1136/gutjnl-2014-307891 – ident: e_1_2_11_248_1 doi: 10.1210/me.2011-0068 – ident: e_1_2_11_168_1 doi: 10.1136/annrheumdis-2013-203305 – ident: e_1_2_11_151_1 doi: 10.1055/s-2005-916319 – ident: e_1_2_11_197_1 doi: 10.1097/MOG.0000000000000041 – ident: e_1_2_11_132_1 doi: 10.1016/j.jaut.2014.01.010 – ident: e_1_2_11_204_1 doi: 10.1111/jop.12187 – ident: e_1_2_11_241_1 doi: 10.1016/j.crohns.2007.11.001 – ident: e_1_2_11_27_1 doi: 10.1016/j.coi.2014.08.005 – ident: e_1_2_11_38_1 doi: 10.1038/nature12199 – ident: e_1_2_11_190_1 doi: 10.1136/gut.45.3.395 – ident: e_1_2_11_194_1 doi: 10.1097/MD.0000000000000309 – ident: e_1_2_11_150_1 doi: 10.1055/s-0034-1383730 – ident: e_1_2_11_2_1 doi: 10.1016/j.jaut.2014.01.004 – ident: e_1_2_11_80_1 doi: 10.1136/gutjnl-2014-306931 – ident: e_1_2_11_106_1 doi: 10.1007/s10495-015-1090-8 – ident: e_1_2_11_230_1 doi: 10.3109/08916934.2012.748752 – ident: e_1_2_11_220_1 doi: 10.1016/j.jaut.2011.06.005 – ident: e_1_2_11_82_1 doi: 10.1371/journal.pone.0033387 – ident: e_1_2_11_167_1 doi: 10.1016/j.autrev.2005.08.005 – ident: e_1_2_11_243_1 doi: 10.1016/S0140-6736(05)66990-5 – ident: e_1_2_11_10_1 doi: 10.1006/clin.1997.4412 – ident: e_1_2_11_200_1 doi: 10.1055/s-0033-1341511 – ident: e_1_2_11_129_1 doi: 10.1016/j.jaut.2014.01.001 – ident: e_1_2_11_158_1 doi: 10.1016/j.autrev.2014.01.029 – ident: e_1_2_11_247_1 doi: 10.1517/14656566.2014.922955 – ident: e_1_2_11_205_1 doi: 10.3389/fgene.2014.00071 – ident: e_1_2_11_28_1 doi: 10.1016/j.jaut.2013.01.008 – ident: e_1_2_11_114_1 doi: 10.1056/NEJM200108023450506 – ident: e_1_2_11_120_1 doi: 10.1016/j.jaut.2014.01.007 – ident: e_1_2_11_117_1 doi: 10.1038/nrrheum.2012.58 – ident: e_1_2_11_233_1 doi: 10.1002/ana.22366 – year: 2014 ident: e_1_2_11_187_1 article-title: Role of genetic and non‐genetic factors in the etiology of Graves' disease publication-title: J Endocrinol Invest – ident: e_1_2_11_135_1 doi: 10.1055/s-0034-1383731 – ident: e_1_2_11_181_1 doi: 10.1055/s-0034-1383725 – ident: e_1_2_11_127_1 doi: 10.1016/j.jaut.2014.01.019 – ident: e_1_2_11_91_1 doi: 10.1016/j.vaccine.2015.01.073 – volume: 35 start-page: 804 year: 2008 ident: e_1_2_11_51_1 article-title: Abnormal histone modification patterns in lupus CD4+ T cells publication-title: J Rheumatol – ident: e_1_2_11_104_1 doi: 10.1186/ar3206 – ident: e_1_2_11_64_1 doi: 10.1007/BF02686087 – ident: e_1_2_11_49_1 doi: 10.1016/j.jneuroim.2012.03.003 – ident: e_1_2_11_185_1 doi: 10.1016/j.ygeno.2015.01.001 – ident: e_1_2_11_121_1 doi: 10.1016/j.jaut.2014.01.029 – ident: e_1_2_11_169_1 doi: 10.1016/S0140-6736(14)60128-8 – ident: e_1_2_11_5_1 doi: 10.4049/jimmunol.76.6.417 – ident: e_1_2_11_138_1 doi: 10.1007/s00281-014-0439-3 – ident: e_1_2_11_78_1 doi: 10.1136/bmj.299.6710.1259 – ident: e_1_2_11_123_1 doi: 10.1016/j.jaut.2014.01.022 – ident: e_1_2_11_209_1 doi: 10.1016/j.cellsig.2013.05.006 – ident: e_1_2_11_126_1 doi: 10.1016/j.jaut.2014.01.020 – volume: 18 start-page: 273 year: 2014 ident: e_1_2_11_226_1 article-title: Enterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes publication-title: Discov Med – ident: e_1_2_11_234_1 doi: 10.2337/dc10-S062 – ident: e_1_2_11_147_1 doi: 10.1016/j.ecl.2010.05.011 – ident: e_1_2_11_221_1 doi: 10.1080/08916930500484849 – ident: e_1_2_11_159_1 doi: 10.1053/j.gastro.2011.10.001 – ident: e_1_2_11_242_1 doi: 10.1136/adc.65.8.909 – ident: e_1_2_11_54_1 doi: 10.1517/14728222.2013.773311 – ident: e_1_2_11_63_1 doi: 10.1128/IAI.69.9.5345-5351.2001 – ident: e_1_2_11_50_1 doi: 10.1002/hep.24630 – ident: e_1_2_11_128_1 doi: 10.1016/j.jaut.2014.01.018 – ident: e_1_2_11_148_1 doi: 10.1111/j.1464-5491.2006.01925.x – ident: e_1_2_11_259_1 doi: 10.1056/NEJMoa032534 – ident: e_1_2_11_109_1 doi: 10.1016/j.autrev.2015.01.017 – ident: e_1_2_11_192_1 doi: 10.1097/MIB.0000000000000179 – ident: e_1_2_11_124_1 doi: 10.1016/j.jaut.2014.01.021 – volume: 2012 start-page: 593720 year: 2012 ident: e_1_2_11_46_1 article-title: Epigenetics and autoimmune diseases publication-title: Autoimmune Dis – ident: e_1_2_11_115_1 doi: 10.1007/s11684-015-0388-9 – ident: e_1_2_11_77_1 doi: 10.1007/s11882-013-0407-3 – ident: e_1_2_11_18_1 doi: 10.1016/j.coi.2005.09.006 – ident: e_1_2_11_119_1 doi: 10.1016/j.jaut.2014.01.006 – ident: e_1_2_11_164_1 doi: 10.1016/j.autrev.2014.01.025 – volume-title: Diagnostic Criteria in Autoimmune Diseases year: 2010 ident: e_1_2_11_239_1 – ident: e_1_2_11_229_1 doi: 10.4049/jimmunol.171.11.5778 – ident: e_1_2_11_12_1 doi: 10.1016/S0140-6736(13)60954-X – ident: e_1_2_11_100_1 doi: 10.1016/j.jaut.2007.11.009 – ident: e_1_2_11_256_1 doi: 10.1016/j.trsl.2014.09.006 – volume: 60 start-page: 1735 year: 2014 ident: e_1_2_11_95_1 article-title: Relationship between toxic metals exposure via cigarette smoking and rheumatoid arthritis publication-title: Clin Lab doi: 10.7754/Clin.Lab.2014.131117 – ident: e_1_2_11_134_1 doi: 10.1002/hep.27313 – ident: e_1_2_11_60_1 doi: 10.1016/j.jaut.2014.03.005 – ident: e_1_2_11_15_1 doi: 10.1136/annrheumdis‐2014‐206334 – ident: e_1_2_11_30_1 doi: 10.1016/j.coi.2012.09.001 – ident: e_1_2_11_43_1 doi: 10.1038/nature10251 – ident: e_1_2_11_210_1 doi: 10.1093/hmg/ddu429 – volume: 7 start-page: 8542 year: 2014 ident: e_1_2_11_193_1 article-title: miR‐29a promotes intestinal epithelial apoptosis in ulcerative colitis by down‐regulating Mcl‐1 publication-title: Int J Clin Exp Pathol – ident: e_1_2_11_225_1 doi: 10.1016/j.mehy.2008.06.029 – ident: e_1_2_11_32_1 doi: 10.1056/NEJMra1100030 – ident: e_1_2_11_231_1 doi: 10.1016/j.jaut.2011.12.007 – ident: e_1_2_11_255_1 doi: 10.1056/NEJM199510123331502 – ident: e_1_2_11_103_1 doi: 10.3389/fimmu.2014.00164 – ident: e_1_2_11_182_1 doi: 10.1016/S1499-3872(12)60136-2 – ident: e_1_2_11_157_1 doi: 10.1007/s12020-012-9703-2 – ident: e_1_2_11_17_1 doi: 10.1016/j.jaut.2012.12.007 – volume: 154 start-page: 3173 year: 1995 ident: e_1_2_11_110_1 article-title: Complement activation by cross‐linked B cell‐membrane IgM publication-title: J Immunol doi: 10.4049/jimmunol.154.7.3173 – ident: e_1_2_11_216_1 doi: 10.1016/j.bbrc.2014.07.085 – ident: e_1_2_11_9_1 doi: 10.4049/jimmunol.1400844 – ident: e_1_2_11_170_1 doi: 10.1016/j.semarthrit.2008.10.007 – ident: e_1_2_11_174_1 doi: 10.1007/s00296-012-2590-2 – ident: e_1_2_11_152_1 doi: 10.1046/j.1440-1746.2003.03165.x – ident: e_1_2_11_213_1 doi: 10.1007/s11926-013-0372-9 – ident: e_1_2_11_172_1 doi: 10.1056/NEJMra1004965 – ident: e_1_2_11_92_1 doi: 10.1016/j.autrev.2012.07.007 – ident: e_1_2_11_145_1 doi: 10.1016/j.jaut.2011.11.003 – ident: e_1_2_11_102_1 doi: 10.1146/annurev.iy.09.040191.001331 – ident: e_1_2_11_57_1 doi: 10.1016/j.jaut.2013.01.009 – ident: e_1_2_11_125_1 doi: 10.1016/j.jaut.2014.01.011 – ident: e_1_2_11_144_1 doi: 10.1016/j.jaut.2014.07.002 – ident: e_1_2_11_113_1 doi: 10.1016/j.jaut.2012.12.006 – ident: e_1_2_11_76_1 doi: 10.1007/BF02806528 – ident: e_1_2_11_222_1 doi: 10.1212/01.wnl.0000326576.91097.87 – ident: e_1_2_11_58_1 doi: 10.1016/j.jaut.2014.03.003 – ident: e_1_2_11_19_1 doi: 10.1056/NEJM199006283222601 – ident: e_1_2_11_240_1 doi: 10.1016/j.crohns.2009.12.003 – ident: e_1_2_11_133_1 doi: 10.1002/hep.27230 – ident: e_1_2_11_253_1 doi: 10.1136/gutjnl-2013-306711 – ident: e_1_2_11_87_1 doi: 10.7554/eLife.01202 – ident: e_1_2_11_21_1 doi: 10.1016/j.jaut.2013.02.004 – volume: 24 start-page: 656 year: 2006 ident: e_1_2_11_85_1 article-title: Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs publication-title: Clin Exp Rheumatol – ident: e_1_2_11_118_1 doi: 10.1016/j.jaut.2014.01.003 – ident: e_1_2_11_7_1 doi: 10.3109/10408369708998095 – ident: e_1_2_11_140_1 doi: 10.1146/annurev-pathol-020712-164014 – ident: e_1_2_11_40_1 doi: 10.1038/ng.543 – ident: e_1_2_11_153_1 doi: 10.1016/S0140-6736(12)62163-1 – ident: e_1_2_11_201_1 doi: 10.1016/j.molimm.2014.02.018 – ident: e_1_2_11_68_1 doi: 10.1084/jem.20030530 – ident: e_1_2_11_97_1 doi: 10.1136/ard.2010.142109 – ident: e_1_2_11_25_1 doi: 10.1097/00002281-200307000-00010 – ident: e_1_2_11_47_1 doi: 10.1371/journal.pone.0036278 – ident: e_1_2_11_65_1 doi: 10.1056/NEJMoa035075 – ident: e_1_2_11_88_1 doi: 10.15252/embj.201489966 – ident: e_1_2_11_251_1 doi: 10.1056/NEJMct1207259 – ident: e_1_2_11_160_1 doi: 10.1016/j.bpg.2014.04.003 – ident: e_1_2_11_33_1 doi: 10.1038/nrrheum.2014.109 – ident: e_1_2_11_207_1 doi: 10.1016/j.jaut.2014.11.006 – ident: e_1_2_11_224_1 doi: 10.2217/ijr.12.82 – ident: e_1_2_11_122_1 doi: 10.1016/j.jaut.2013.11.005 – ident: e_1_2_11_156_1 doi: 10.1016/j.autrev.2014.01.013 – ident: e_1_2_11_143_1 doi: 10.12659/AOT.890753 – ident: e_1_2_11_116_1 doi: 10.1016/j.autrev.2014.10.012 – ident: e_1_2_11_250_1 doi: 10.1016/j.jpeds.2013.10.029 – ident: e_1_2_11_11_1 doi: 10.1016/j.jaut.2007.05.002 – ident: e_1_2_11_137_1 doi: 10.1016/j.autrev.2007.01.006 – ident: e_1_2_11_180_1 doi: 10.1530/JOE-13-0544 – ident: e_1_2_11_13_1 doi: 10.1016/j.autrev.2009.11.010 – ident: e_1_2_11_257_1 doi: 10.1517/17425255.2015.992779 – ident: e_1_2_11_195_1 doi: 10.4161/epi.29446 – ident: e_1_2_11_198_1 doi: 10.1038/nrgastro.2013.232 – ident: e_1_2_11_186_1 doi: 10.1146/annurev-pathol-012513-104713 – ident: e_1_2_11_165_1 doi: 10.1016/S0140-6736(03)13492-7 – ident: e_1_2_11_90_1 doi: 10.1016/S1568-9972(01)00016-7 – ident: e_1_2_11_189_1 doi: 10.1146/annurev-genom-082908-150013 – ident: e_1_2_11_214_1 doi: 10.1038/nrrheum.2015.7 – ident: e_1_2_11_246_1 doi: 10.1136/ard.2010.138461 – ident: e_1_2_11_23_1 doi: 10.1016/S0140-6736(96)02293-3 – ident: e_1_2_11_178_1 doi: 10.1542/peds.2013-1652 – ident: e_1_2_11_237_1 doi: 10.1002/hep.22322 – ident: e_1_2_11_35_1 doi: 10.1093/hmg/ddu455 – ident: e_1_2_11_96_1 doi: 10.1007/s00296-013-2889-7 – ident: e_1_2_11_79_1 doi: 10.1111/cei.12321 – volume: 106 start-page: 325 year: 2014 ident: e_1_2_11_196_1 article-title: MicroRNAs: an epigenetic tool to study celiac disease publication-title: Rev Esp Enferm Dig – ident: e_1_2_11_84_1 doi: 10.1111/j.1600-051X.2009.01496.x – ident: e_1_2_11_166_1 doi: 10.1093/rheumatology/kei107 – ident: e_1_2_11_16_1 doi: 10.1136/annrheumdis-2013-204627 – ident: e_1_2_11_219_1 doi: 10.1073/pnas.071050898 – ident: e_1_2_11_53_1 doi: 10.1111/j.1582-4934.2011.01456.x – ident: e_1_2_11_142_1 doi: 10.1055/s-0034-1383726 – ident: e_1_2_11_130_1 doi: 10.1016/j.jaut.2014.01.016 – ident: e_1_2_11_244_1 doi: 10.1002/acr.21591 – ident: e_1_2_11_61_1 doi: 10.1016/j.autrev.2012.12.005 – ident: e_1_2_11_202_1 doi: 10.1186/1471-2350-12-111 – ident: e_1_2_11_223_1 doi: 10.1002/art.1780330711 – ident: e_1_2_11_228_1 doi: 10.1093/rheumatology/keq214 – ident: e_1_2_11_41_1 doi: 10.1038/ng.249 – ident: e_1_2_11_55_1 doi: 10.1155/2014/527895 – ident: e_1_2_11_199_1 doi: 10.1093/hmg/ddt520 – ident: e_1_2_11_183_1 doi: 10.12659/MSM.890686 – ident: e_1_2_11_218_1 doi: 10.4049/jimmunol.0900709 – ident: e_1_2_11_136_1 doi: 10.1016/j.jaut.2014.01.027 – ident: e_1_2_11_176_1 doi: 10.1016/j.clim.2014.12.013 – ident: e_1_2_11_99_1 doi: 10.1016/j.jaut.2009.12.003 – year: 2014 ident: e_1_2_11_107_1 article-title: Serological markers of enterocyte damage and apoptosis in patients with celiac disease, autoimmune diabetes mellitus and diabetes mellitus type 2 publication-title: Physiol Res – ident: e_1_2_11_8_1 doi: 10.1016/j.jaut.2013.01.006 – ident: e_1_2_11_73_1 doi: 10.1016/j.it.2009.05.005 – ident: e_1_2_11_52_1 doi: 10.1186/ar1702 – ident: e_1_2_11_258_1 doi: 10.1111/ced.12390 – ident: e_1_2_11_29_1 doi: 10.1016/j.jaut.2013.01.010 – volume: 32 start-page: 761 year: 2014 ident: e_1_2_11_203_1 article-title: Discovery and validation of novel microRNAs in Sjogren's syndrome salivary glands publication-title: Clin Exp Rheumatol – ident: e_1_2_11_249_1 doi: 10.1016/B978-0-444-52001-2.00020-0 – volume: 8 start-page: 87 year: 2014 ident: e_1_2_11_260_1 article-title: Rituximab for the treatment of rheumatoid arthritis: an update publication-title: Drug Des Devel Ther – ident: e_1_2_11_75_1 doi: 10.1097/01.EPX.0000452287.65133.fc – ident: e_1_2_11_254_1 doi: 10.1111/cei.12217 – ident: e_1_2_11_215_1 doi: 10.1097/BOR.0000000000000012 – ident: e_1_2_11_131_1 doi: 10.1016/j.jaut.2014.01.015 – ident: e_1_2_11_171_1 doi: 10.1177/0961203313512881 – ident: e_1_2_11_101_1 doi: 10.1016/j.jaut.2008.04.009 – ident: e_1_2_11_235_1 doi: 10.1002/hep.22906 – ident: e_1_2_11_98_1 doi: 10.1136/annrheumdis-2013-204486 – ident: e_1_2_11_206_1 doi: 10.1038/ng.2792 – ident: e_1_2_11_236_1 doi: 10.1016/S0168-8278(99)80297-9 – ident: e_1_2_11_62_1 doi: 10.3109/08830185.2014.917411 – ident: e_1_2_11_70_1 doi: 10.1111/j.1600-065X.1998.tb01207.x – ident: e_1_2_11_74_1 doi: 10.1155/2013/535738 – ident: e_1_2_11_146_1 doi: 10.1016/S1474-4422(14)70041-9 – ident: e_1_2_11_162_1 doi: 10.1111/apt.12373 – ident: e_1_2_11_48_1 doi: 10.1177/1352458511421055 – ident: e_1_2_11_4_1 doi: 10.1038/ni0705-639 – ident: e_1_2_11_245_1 doi: 10.1002/art.34473 – ident: e_1_2_11_252_1 doi: 10.2174/138955708785132756 – ident: e_1_2_11_211_1 doi: 10.1097/BOR.0000000000000086 – ident: e_1_2_11_42_1 doi: 10.1038/ng.717 – ident: e_1_2_11_89_1 doi: 10.1056/NEJMra071600 – ident: e_1_2_11_179_1 doi: 10.1016/j.jaut.2013.10.001
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Snippet	There have been significant advances in our understanding of human autoimmunity that have led to improvements in classification and diagnosis and, most...
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SubjectTerms	autoantibodies Autoimmune Diseases - epidemiology Autoimmune Diseases - etiology Autoimmune Diseases - genetics Autoimmune Diseases - therapy Environmental Exposure Female Genetic Predisposition to Disease genetics and autoimmunity Humans Immune Tolerance Immunopathology Male Models, Biological Twin Studies as Topic
Title	Human autoimmune diseases: a comprehensive update
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