Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity

• Published in: Clinical and experimental allergy Vol. 38; no. 2; pp. 374 - 381
• Main Authors: Saarelainen, S., Rytkönen-Nissinen, M., Rouvinen, J., Taivainen, A., Auriola, S., Kauppinen, A., Kinnunen, T., Virtanen, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2008; Blackwell
• Subjects: Adult; Allergens - chemistry; Allergens - genetics; Allergens - immunology; allergy; Amino Acid Sequence; Animals; Biological and medical sciences; Cattle; Cross Reactions; cross-reactivity; Dogs; endogenous lipocalin; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Horses - immunology; Humans; Immunoglobulin E - immunology; Lipocalin 1 - chemistry; Lipocalin 1 - immunology; lipocalin allergen; Lipocalins - chemistry; Lipocalins - genetics; Lipocalins - immunology; Male; Mice; Middle Aged; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins - biosynthesis; Recombinant Proteins - immunology; Sequence Alignment; three-dimensional structure; Immunopathology; Allergy; endogenous lipocalin; Immunology; Animal; IgE; Cross reaction; cross-reactivity; Allergen; lipocalin allergen; threedimensional structure

Summary Background Although knowledge of the IgE cross‐reactivity between allergens is important for understanding the mechanisms of allergy, the regulation of the allergic immune response and the development of efficient modes of allergen immunotherapy, the cross‐reactivity of animal allergens is p...