Fos/AP-1 proteins in bone and the immune system

• Published in: Immunological reviews Vol. 208; no. 1; pp. 126 - 140
• Main Authors: Wagner, Erwin F., Eferl, Robert
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden, USA Munksgaard International Publishers 01.12.2005
• Subjects: Adaptor Proteins, Signal Transducing; Animals; Arthritis, Rheumatoid - etiology; Bone and Bones - physiology; Bone Resorption - etiology; Carrier Proteins - physiology; Chondrocytes - physiology; Humans; Immune System - physiology; Immunity, Innate; Inflammation - etiology; Membrane Glycoproteins - physiology; Membrane Proteins; Osteoblasts - physiology; Osteosarcoma - etiology; Proto-Oncogene Proteins c-fos - physiology; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Immunologic - physiology; Transcription Factor AP-1 - physiology

The skeleton and the immune system share a variety of different cytokines and transcription factors, thereby mutually influencing each other. These interactions are not confined to the bone marrow cavity where bone cells and hematopoietic cells exist in proximity but also occur at locations that are...