Topiramate for Migraine Prevention in Children: A Randomized, Double-Blind, Placebo-Controlled Trial

• Published in: Headache Vol. 45; no. 10; pp. 1304 - 1312
• Main Authors: Winner, Paul, Pearlman, Eric M., Linder, Stephen L., Jordan, Donna M., Fisher, Alan C., Hulihan, Joseph
• Format: Journal Article
• Language: English
• Published: 350 Main Street , Malden , MA 02148 , USA Blackwell Science Inc 01.11.2005; Blackwell
• Subjects: Adolescent; Biological and medical sciences; Cardiovascular system; Child; Double-Blind Method; Female; Fructose - adverse effects; Fructose - analogs & derivatives; Fructose - therapeutic use; Humans; Male; Medical sciences; Migraine Disorders - prevention & control; Migraine with Aura - prevention & control; Migraine without Aura - prevention & control; migration prevention therapy; Muscle; Neurology; Neuropharmacology; Neuroprotective Agents - adverse effects; Neuroprotective Agents - therapeutic use; pediatric migraine; Pharmacology. Drug treatments; Pilot Projects; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; topiramate; Vascular diseases and vascular malformations of the nervous system; Vasodilator agents. Cerebral vasodilators; United States; North America; America; Sensitivity disorder; Headache; Topiramate; Gastroenteritis; Cardiovascular disease; Anticonvulsant; Paresthesia; Incidence; Vascular disease; Prevention; Respiratory tract; Pain; Intestinal disease; Complication; Neurological disorder; Aura; Child; Cerebrovascular disease; Gastric disease; Human; Blind; Nervous system diseases; Migraine; Medical screening; Cerebral disorder; Infection; migration prevention therapy; Chemotherapy; Treatment; Central nervous system disease; Digestive diseases; pediatric migraine; Daily dose

Objective.—To assess the efficacy and safety of topiramate for the prevention of pediatric migraine with or without aura in a double‐blind, randomized, placebo‐controlled trial. Background.—Treatment options for pediatric migraine are currently limited, and no migraine preventive agents are approved...