Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects

• Published in: Journal of controlled release Vol. 196; pp. 79 - 86
• Main Authors: Lei, Yang, Nosoudi, Nasim, Vyavahare, Naren
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.12.2014
• Subjects: Aged; Albumin nanoparticles; Albumins - chemistry; Animals; Arteriosclerosis; Calcinosis - drug therapy; Calcinosis - pathology; Chelating Agents - administration & dosage; Chelating Agents - adverse effects; Chelating Agents - therapeutic use; Chelation Therapy - adverse effects; Chelation Therapy - methods; Drug Delivery Systems; Edetic Acid - administration & dosage; Edetic Acid - adverse effects; Edetic Acid - therapeutic use; Elastin antibody; Female; Humans; In Vitro Techniques; Male; Medial calcification; Middle Aged; Nanoparticles; Rats; Swine; Targeted EDTA chelation therapy; Albumin nanoparticles; Elastin antibody; Arteriosclerosis; Targeted EDTA chelation therapy; Medial calcification

Elastin-specific medial arterial calcification (MAC) is an arterial disease commonly referred as Monckeberg's sclerosis. It causes significant arterial stiffness, and as yet, no clinical therapy exists to prevent or reverse it. We developed albumin nanoparticles (NPs) loaded with disodium ethyl...