Integration of canal and otolith inputs by central vestibular neurons is subadditive for both active and passive self-motion: implication for perception
Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural vestibular stimuli are typically more complex. During everyday life, our self-motion is generally not restricted to one dimension, but rather co...
Saved in:
Published in | The Journal of neuroscience Vol. 35; no. 8; pp. 3555 - 3565 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for Neuroscience
25.02.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural vestibular stimuli are typically more complex. During everyday life, our self-motion is generally not restricted to one dimension, but rather comprises both rotational and translational motion that will simultaneously stimulate receptors in the semicircular canals and otoliths. In addition, natural self-motion is the result of self-generated and externally generated movements. However, to date, it remains unknown how information about rotational and translational components of self-motion is integrated by vestibular pathways during active and/or passive motion. Accordingly, here, we compared the responses of neurons at the first central stage of vestibular processing to rotation, translation, and combined motion. Recordings were made in alert macaques from neurons in the vestibular nuclei involved in postural control and self-motion perception. In response to passive stimulation, neurons did not combine canal and otolith afferent information linearly. Instead, inputs were subadditively integrated with a weighting that was frequency dependent. Although canal inputs were more heavily weighted at low frequencies, the weighting of otolith input increased with frequency. In response to active stimulation, neuronal modulation was significantly attenuated (∼ 70%) relative to passive stimulation for rotations and translations and even more profoundly attenuated for combined motion due to subadditive input integration. Together, these findings provide insights into neural computations underlying the integration of semicircular canal and otolith inputs required for accurate posture and motor control, as well as perceptual stability, during everyday life. |
---|---|
AbstractList | Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural vestibular stimuli are typically more complex. During everyday life, our self-motion is generally not restricted to one dimension, but rather comprises both rotational and translational motion that will simultaneously stimulate receptors in the semicircular canals and otoliths. In addition, natural self-motion is the result of self-generated and externally generated movements. However, to date, it remains unknown how information about rotational and translational components of self-motion is integrated by vestibular pathways during active and/or passive motion. Accordingly, here, we compared the responses of neurons at the first central stage of vestibular processing to rotation, translation, and combined motion. Recordings were made in alert macaques from neurons in the vestibular nuclei involved in postural control and self-motion perception. In response to passive stimulation, neurons did not combine canal and otolith afferent information linearly. Instead, inputs were subadditively integrated with a weighting that was frequency dependent. Although canal inputs were more heavily weighted at low frequencies, the weighting of otolith input increased with frequency. In response to active stimulation, neuronal modulation was significantly attenuated (∼ 70%) relative to passive stimulation for rotations and translations and even more profoundly attenuated for combined motion due to subadditive input integration. Together, these findings provide insights into neural computations underlying the integration of semicircular canal and otolith inputs required for accurate posture and motor control, as well as perceptual stability, during everyday life. Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural vestibular stimuli are typically more complex. During everyday life, our self-motion is generally not restricted to one dimension, but rather comprises both rotational and translational motion that will simultaneously stimulate receptors in the semicircular canals and otoliths. In addition, natural self-motion is the result of self-generated and externally generated movements. However, to date, it remains unknown how information about rotational and translational components of self-motion is integrated by vestibular pathways during active and/or passive motion. Accordingly, here, we compared the responses of neurons at the first central stage of vestibular processing to rotation, translation, and combined motion. Recordings were made in alert macaques from neurons in the vestibular nuclei involved in postural control and self-motion perception. In response to passive stimulation, neurons did not combine canal and otolith afferent information linearly. Instead, inputs were subadditively integrated with a weighting that was frequency dependent. Although canal inputs were more heavily weighted at low frequencies, the weighting of otolith input increased with frequency. In response to active stimulation, neuronal modulation was significantly attenuated (∼70%) relative to passive stimulation for rotations and translations and even more profoundly attenuated for combined motion due to subadditive input integration. Together, these findings provide insights into neural computations underlying the integration of semicircular canal and otolith inputs required for accurate posture and motor control, as well as perceptual stability, during everyday life. Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural vestibular stimuli are typically more complex. During everyday life, our self-motion is generally not restricted to one dimension, but rather comprises both rotational and translational motion that will simultaneously stimulate receptors in the semicircular canals and otoliths. In addition, natural self-motion is the result of self-generated and externally generated movements. However, to date, it remains unknown how information about rotational and translational components of self-motion is integrated by vestibular pathways during active and/or passive motion. Accordingly, here, we compared the responses of neurons at the first central stage of vestibular processing to rotation, translation, and combined motion. Recordings were made in alert macaques from neurons in the vestibular nuclei involved in postural control and self-motion perception. In response to passive stimulation, neurons did not combine canal and otolith afferent information linearly. Instead, inputs were subadditively integrated with a weighting that was frequency dependent. Although canal inputs were more heavily weighted at low frequencies, the weighting of otolith input increased with frequency. In response to active stimulation, neuronal modulation was significantly attenuated (~70%) relative to passive stimulation for rotations and translations and even more profoundly attenuated for combined motion due to subadditive input integration. Together, these findings provide insights into neural computations underlying the integration of semicircular canal and otolith inputs required for accurate posture and motor control, as well as perceptual stability, during everyday life. |
Author | Brooks, Jessica X Cullen, Kathleen E Carriot, Jerome Jamali, Mohsen |
Author_xml | – sequence: 1 givenname: Jerome surname: Carriot fullname: Carriot, Jerome organization: Department of Physiology McGill University, Montreal, Quebec, Canada H3G 1Y6 – sequence: 2 givenname: Mohsen surname: Jamali fullname: Jamali, Mohsen organization: Department of Physiology McGill University, Montreal, Quebec, Canada H3G 1Y6 – sequence: 3 givenname: Jessica X surname: Brooks fullname: Brooks, Jessica X organization: Department of Physiology McGill University, Montreal, Quebec, Canada H3G 1Y6 – sequence: 4 givenname: Kathleen E orcidid: 0000-0002-9348-0933 surname: Cullen fullname: Cullen, Kathleen E email: kathleen.cullen@mcgill.ca organization: Department of Physiology McGill University, Montreal, Quebec, Canada H3G 1Y6 kathleen.cullen@mcgill.ca |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25716854$$D View this record in MEDLINE/PubMed |
BookMark | eNqFUstu1DAUtVArOi38QuUlmwx-5sECCY1aGFRRqY-15TjXrVFiBzsZqX_C5-IwwwhWrHyv7jnnPnzO0YkPHhC6pGRNJePvv367ery7vd9s11wKUlCxZoTKV2iVq03BBKEnaEVYRYpSVOIMnaf0nRBSEVq9RmdMVrSspVihn1s_wVPUkwseB4uN9rrH2nc4TKF30zN2fpynhNsXbMBPMVd3kCbXzr2O2MMcg0_YJZzmVnedm9wOsA0RtyGTtfmdL3qjTmmJE_S2GMLS8AN2w9g7s---kEaIBsYlfYNOre4TvD28F-jx-uph86W4uf283Xy6KYwkZCoARNfVNWkqCjUwxmmdD1AaVjPOeUNMHgparSnh1FrLmJWsJlbaTlNNreAX6ONed5zbAbrDjmqMbtDxRQXt1L8V757VU9gpkeV5SbLAu4NADD_mfBo1uGSg77WHMCdFq1I2NZNU_h-akRktmyZDyz3UxJBSBHuciBK1OEAdHaAWBygq1OKATLz8e58j7c-X81-L4rRP |
CitedBy_id | crossref_primary_10_1152_jn_00073_2016 crossref_primary_10_7554_eLife_26179 crossref_primary_10_3389_fneur_2021_635305 crossref_primary_10_1016_j_cub_2019_07_006 crossref_primary_10_1016_j_cub_2023_09_047 crossref_primary_10_1007_s11517_017_1618_x crossref_primary_10_7224_1537_2073_2016_027 crossref_primary_10_1007_s10162_018_0657_9 crossref_primary_10_1016_j_neuroimage_2016_07_029 crossref_primary_10_1016_j_celrep_2016_03_089 crossref_primary_10_1152_jn_00382_2017 crossref_primary_10_1007_s12070_021_02867_4 crossref_primary_10_3389_fncel_2018_00456 crossref_primary_10_3389_fneur_2018_00489 crossref_primary_10_1007_s10439_022_02947_8 crossref_primary_10_3389_fneur_2015_00269 crossref_primary_10_1080_07420528_2016_1215993 crossref_primary_10_1097_AUD_0000000000000619 crossref_primary_10_3389_fneur_2023_1266345 crossref_primary_10_1093_cercor_bhx325 crossref_primary_10_1007_s00221_022_06393_9 crossref_primary_10_1007_s00415_015_7909_y crossref_primary_10_1109_ACCESS_2020_3022554 crossref_primary_10_7554_eLife_43019 crossref_primary_10_1038_nn_4658 crossref_primary_10_1371_journal_pcbi_1007489 crossref_primary_10_3389_fneur_2018_00979 crossref_primary_10_3389_fneur_2023_1266513 crossref_primary_10_1152_jn_00350_2019 crossref_primary_10_1038_s41583_019_0153_1 crossref_primary_10_1016_j_bpsc_2019_06_003 crossref_primary_10_1002_bem_22417 crossref_primary_10_1016_j_conb_2018_04_004 crossref_primary_10_1097_WCO_0000000000001228 crossref_primary_10_3389_fneur_2019_00063 crossref_primary_10_1109_ACCESS_2020_2997643 crossref_primary_10_3758_s13414_019_01691_x |
Cites_doi | 10.1007/s00422-001-0289-7 10.1007/s00221-011-2568-4 10.1016/j.conb.2011.05.022 10.1152/jn.1999.82.1.416 10.1007/s002210000575 10.1152/jn.01067.2009 10.1016/j.neuron.2009.11.010 10.1152/jn.91066.2008 10.1007/s002210050496 10.1152/jn.1992.68.1.244 10.1152/jn.1993.70.2.828 10.1152/jn.01234.2003 10.1007/s00422-001-0290-1 10.1152/jn.1999.82.1.34 10.1038/nature02754 10.1152/jn.00710.2009 10.1523/JNEUROSCI.4690-06.2007 10.1523/JNEUROSCI.23-28-09265.2003 10.1007/s00221-006-0486-7 10.1152/jn.1988.60.5.1753 10.1523/JNEUROSCI.21-06-02131.2001 10.1523/JNEUROSCI.19-01-00316.1999 10.1016/S0361-9230(98)00007-0 10.1152/jn.00018.2007 10.1152/jn.00518.2002 10.1038/nrn2331 10.1007/978-1-4757-3054-8_29 10.1152/jn.00926.2004 10.1016/j.tins.2011.12.001 10.1523/JNEUROSCI.0692-14.2014 10.1152/jn.00459.2005 10.1007/s002210050495 10.1007/s002210050033 10.1523/JNEUROSCI.2646-06.2007 10.1152/jn.00829.2006 10.1371/journal.pbio.1001365 10.1007/s00221-011-2717-9 10.1111/j.1469-7793.1997.223bl.x 10.1523/JNEUROSCI.3051-13.2013 10.1038/19303 10.1016/j.neuron.2008.06.024 10.1523/JNEUROSCI.3437-09.2009 10.1007/s00221-005-2341-7 10.1146/annurev.neuro.31.060407.125555 10.1038/1619 10.1016/j.jneumeth.2008.05.021 10.1016/j.neuroscience.2011.06.070 10.1201/9780203735701-46 10.1111/j.1749-6632.2001.tb03776.x 10.1523/JNEUROSCI.1937-09.2009 10.1152/jn.1999.82.5.2612 10.1007/BF00161093 10.1038/nn.2191 10.1016/0957-4271(95)02039-X 10.1523/JNEUROSCI.22-11-j0002.2002 10.1523/JNEUROSCI.3988-03.2004 |
ContentType | Journal Article |
Copyright | Copyright © 2015 the authors 0270-6474/15/353555-11$15.00/0. Copyright © 2015 the authors 0270-6474/15/353555-11$15.00/0 2015 |
Copyright_xml | – notice: Copyright © 2015 the authors 0270-6474/15/353555-11$15.00/0. – notice: Copyright © 2015 the authors 0270-6474/15/353555-11$15.00/0 2015 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TK 5PM |
DOI | 10.1523/JNEUROSCI.3540-14.2015 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Neurosciences Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Neurosciences Abstracts |
DatabaseTitleList | MEDLINE Neurosciences Abstracts MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1529-2401 |
EndPage | 3565 |
ExternalDocumentID | 10_1523_JNEUROSCI_3540_14_2015 25716854 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: Canadian Institutes of Health Research – fundername: NIDCD NIH HHS grantid: DC2390 – fundername: NIDCD NIH HHS grantid: R01 DC002390 |
GroupedDBID | --- -DZ -~X .55 18M 2WC 34G 39C 53G 5GY 5RE 5VS AAFWJ ABBAR ABIVO ACGUR ACNCT ADBBV ADCOW AENEX AETEA AFCFT AFHIN AFOSN AHWXS AIZTS ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P GX1 HYE H~9 KQ8 L7B NPM OK1 P0W P2P QZG R.V RHF RHI RPM TFN TR2 W8F WH7 WOQ X7M XJT YBU YHG YKV YNH YSK ZA5 AAYXX CITATION H13 7X8 7TK 5PM |
ID | FETCH-LOGICAL-c500t-ee4dd880971e8e223185296c28233390cbadebaa1031fff22f5280f5fda1a1f43 |
IEDL.DBID | RPM |
ISSN | 0270-6474 |
IngestDate | Tue Sep 17 21:28:06 EDT 2024 Fri Aug 16 10:40:02 EDT 2024 Thu Jul 25 11:25:31 EDT 2024 Fri Aug 23 02:33:48 EDT 2024 Thu May 23 23:48:00 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Keywords | translation sensory integration head motion voluntary vestibular nuclei rotation |
Language | English |
License | Copyright © 2015 the authors 0270-6474/15/353555-11$15.00/0. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c500t-ee4dd880971e8e223185296c28233390cbadebaa1031fff22f5280f5fda1a1f43 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: J.C., M.J., and K.E.C. designed research; J.C. and J.X.B. performed research; J.C. and M.J. analyzed data; J.C., M.J., and K.E.C. wrote the paper. J.C. and M.J. contributed equally to this work. |
ORCID | 0000-0002-9348-0933 |
OpenAccessLink | https://www.jneurosci.org/content/jneuro/35/8/3555.full.pdf |
PMID | 25716854 |
PQID | 1659765599 |
PQPubID | 23479 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4339360 proquest_miscellaneous_1765982515 proquest_miscellaneous_1659765599 crossref_primary_10_1523_JNEUROSCI_3540_14_2015 pubmed_primary_25716854 |
PublicationCentury | 2000 |
PublicationDate | 2015-02-25 |
PublicationDateYYYYMMDD | 2015-02-25 |
PublicationDate_xml | – month: 02 year: 2015 text: 2015-02-25 day: 25 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of neuroscience |
PublicationTitleAlternate | J Neurosci |
PublicationYear | 2015 |
Publisher | Society for Neuroscience |
Publisher_xml | – name: Society for Neuroscience |
References | Cullen (2023041304154581000_35.8.3555.18) 2002; 22 2023041304154581000_35.8.3555.27 2023041304154581000_35.8.3555.28 2023041304154581000_35.8.3555.23 2023041304154581000_35.8.3555.22 2023041304154581000_35.8.3555.25 2023041304154581000_35.8.3555.24 2023041304154581000_35.8.3555.30 2023041304154581000_35.8.3555.32 2023041304154581000_35.8.3555.31 Hayes (2023041304154581000_35.8.3555.29) 1982; 2 2023041304154581000_35.8.3555.19 2023041304154581000_35.8.3555.16 2023041304154581000_35.8.3555.15 2023041304154581000_35.8.3555.59 2023041304154581000_35.8.3555.12 2023041304154581000_35.8.3555.56 2023041304154581000_35.8.3555.11 2023041304154581000_35.8.3555.14 2023041304154581000_35.8.3555.58 2023041304154581000_35.8.3555.13 2023041304154581000_35.8.3555.57 2023041304154581000_35.8.3555.21 2023041304154581000_35.8.3555.20 McCrea (2023041304154581000_35.8.3555.38) 1999; 82 Roy (2023041304154581000_35.8.3555.44) 2001; 21 Scudder (2023041304154581000_35.8.3555.51) 1992; 68 2023041304154581000_35.8.3555.1 Kasper (2023041304154581000_35.8.3555.33) 1988; 60 2023041304154581000_35.8.3555.2 2023041304154581000_35.8.3555.5 2023041304154581000_35.8.3555.4 2023041304154581000_35.8.3555.7 2023041304154581000_35.8.3555.6 Angelaki (2023041304154581000_35.8.3555.3) 1999; 19 2023041304154581000_35.8.3555.9 Green (2023041304154581000_35.8.3555.26) 2003; 23 2023041304154581000_35.8.3555.49 2023041304154581000_35.8.3555.8 2023041304154581000_35.8.3555.48 Sylvestre (2023041304154581000_35.8.3555.55) 1999; 82 2023041304154581000_35.8.3555.45 2023041304154581000_35.8.3555.47 2023041304154581000_35.8.3555.46 2023041304154581000_35.8.3555.10 2023041304154581000_35.8.3555.54 2023041304154581000_35.8.3555.53 Mittelstaedt (2023041304154581000_35.8.3555.40) 1991; 95 Siebold (2023041304154581000_35.8.3555.52) 1999; 82 Cullen (2023041304154581000_35.8.3555.17) 1993; 70 Schneider (2023041304154581000_35.8.3555.50) 2013; 43 2023041304154581000_35.8.3555.37 2023041304154581000_35.8.3555.39 2023041304154581000_35.8.3555.34 2023041304154581000_35.8.3555.36 2023041304154581000_35.8.3555.35 2023041304154581000_35.8.3555.41 2023041304154581000_35.8.3555.43 2023041304154581000_35.8.3555.42 |
References_xml | – ident: 2023041304154581000_35.8.3555.10 doi: 10.1007/s00422-001-0289-7 – ident: 2023041304154581000_35.8.3555.34 doi: 10.1007/s00221-011-2568-4 – ident: 2023041304154581000_35.8.3555.15 doi: 10.1016/j.conb.2011.05.022 – volume: 82 start-page: 416 year: 1999 ident: 2023041304154581000_35.8.3555.38 article-title: Firing behavior of vestibular neurons during active and passive head movements: vestibulo-spinal and other non-eye-movement related neurons publication-title: J Neurophysiol doi: 10.1152/jn.1999.82.1.416 contributor: fullname: McCrea – ident: 2023041304154581000_35.8.3555.53 doi: 10.1007/s002210000575 – ident: 2023041304154581000_35.8.3555.35 doi: 10.1152/jn.01067.2009 – volume: 2 start-page: 1 year: 1982 ident: 2023041304154581000_35.8.3555.29 article-title: A UNIX-based multiple process system for real-time data acquisition and control publication-title: WESCON Conf Proc contributor: fullname: Hayes – ident: 2023041304154581000_35.8.3555.5 doi: 10.1016/j.neuron.2009.11.010 – ident: 2023041304154581000_35.8.3555.31 doi: 10.1152/jn.91066.2008 – ident: 2023041304154581000_35.8.3555.7 doi: 10.1007/s002210050496 – volume: 68 start-page: 244 year: 1992 ident: 2023041304154581000_35.8.3555.51 article-title: Physiological and behavioral identification of vestibular nucleus neurons mediating the horizontal vestibuloocular reflex in trained rhesus monkeys publication-title: J Neurophysiol doi: 10.1152/jn.1992.68.1.244 contributor: fullname: Scudder – volume: 70 start-page: 828 year: 1993 ident: 2023041304154581000_35.8.3555.17 article-title: Firing behavior of brain stem neurons during voluntary cancellation of the horizontal vestibuloocular reflex. I. Secondary vestibular neurons publication-title: J Neurophysiol doi: 10.1152/jn.1993.70.2.828 contributor: fullname: Cullen – ident: 2023041304154581000_35.8.3555.27 doi: 10.1152/jn.01234.2003 – ident: 2023041304154581000_35.8.3555.59 doi: 10.1007/s00422-001-0290-1 – volume: 82 start-page: 34 year: 1999 ident: 2023041304154581000_35.8.3555.52 article-title: Fastigial nucleus activity during different frequencies and orientations of vertical vestibular stimulation in the monkey publication-title: J Neurophysiol doi: 10.1152/jn.1999.82.1.34 contributor: fullname: Siebold – ident: 2023041304154581000_35.8.3555.4 doi: 10.1038/nature02754 – ident: 2023041304154581000_35.8.3555.49 doi: 10.1152/jn.00710.2009 – ident: 2023041304154581000_35.8.3555.48 doi: 10.1523/JNEUROSCI.4690-06.2007 – volume: 23 start-page: 9265 year: 2003 ident: 2023041304154581000_35.8.3555.26 article-title: Resolution of sensory ambiguities for gaze stabilization requires a second neural integrator publication-title: J Neurosci doi: 10.1523/JNEUROSCI.23-28-09265.2003 contributor: fullname: Green – ident: 2023041304154581000_35.8.3555.32 doi: 10.1007/s00221-006-0486-7 – volume: 60 start-page: 1753 year: 1988 ident: 2023041304154581000_35.8.3555.33 article-title: Response of vestibular neurons to head rotations in vertical planes. I. Response to vestibular stimulation publication-title: J Neurophysiol doi: 10.1152/jn.1988.60.5.1753 contributor: fullname: Kasper – volume: 21 start-page: 2131 year: 2001 ident: 2023041304154581000_35.8.3555.44 article-title: Selective processing of vestibular reafference during self-generated head motion publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-06-02131.2001 contributor: fullname: Roy – volume: 19 start-page: 316 year: 1999 ident: 2023041304154581000_35.8.3555.3 article-title: Computation of inertial motion: neural strategies to resolve ambiguous otolith information publication-title: J Neurosci doi: 10.1523/JNEUROSCI.19-01-00316.1999 contributor: fullname: Angelaki – ident: 2023041304154581000_35.8.3555.22 doi: 10.1016/S0361-9230(98)00007-0 – ident: 2023041304154581000_35.8.3555.1 doi: 10.1152/jn.00018.2007 – ident: 2023041304154581000_35.8.3555.21 doi: 10.1152/jn.00518.2002 – ident: 2023041304154581000_35.8.3555.54 doi: 10.1038/nrn2331 – ident: 2023041304154581000_35.8.3555.9 doi: 10.1007/978-1-4757-3054-8_29 – ident: 2023041304154581000_35.8.3555.42 doi: 10.1152/jn.00926.2004 – ident: 2023041304154581000_35.8.3555.16 doi: 10.1016/j.tins.2011.12.001 – volume: 95 start-page: 427 year: 1991 ident: 2023041304154581000_35.8.3555.40 article-title: Idiothetic navigation in gerbils and humans publication-title: Zool Jahrb Allg Zool contributor: fullname: Mittelstaedt – ident: 2023041304154581000_35.8.3555.13 doi: 10.1523/JNEUROSCI.0692-14.2014 – ident: 2023041304154581000_35.8.3555.58 doi: 10.1152/jn.00459.2005 – ident: 2023041304154581000_35.8.3555.8 doi: 10.1007/s002210050495 – ident: 2023041304154581000_35.8.3555.25 doi: 10.1007/s002210050033 – ident: 2023041304154581000_35.8.3555.6 doi: 10.1523/JNEUROSCI.2646-06.2007 – ident: 2023041304154581000_35.8.3555.47 doi: 10.1152/jn.00829.2006 – ident: 2023041304154581000_35.8.3555.36 doi: 10.1371/journal.pbio.1001365 – ident: 2023041304154581000_35.8.3555.23 doi: 10.1007/s00221-011-2717-9 – ident: 2023041304154581000_35.8.3555.30 doi: 10.1111/j.1469-7793.1997.223bl.x – ident: 2023041304154581000_35.8.3555.12 doi: 10.1523/JNEUROSCI.3051-13.2013 – ident: 2023041304154581000_35.8.3555.39 doi: 10.1038/19303 – ident: 2023041304154581000_35.8.3555.41 doi: 10.1016/j.neuron.2008.06.024 – ident: 2023041304154581000_35.8.3555.20 doi: 10.1523/JNEUROSCI.3437-09.2009 – ident: 2023041304154581000_35.8.3555.57 doi: 10.1007/s00221-005-2341-7 – ident: 2023041304154581000_35.8.3555.2 doi: 10.1146/annurev.neuro.31.060407.125555 – ident: 2023041304154581000_35.8.3555.43 doi: 10.1038/1619 – ident: 2023041304154581000_35.8.3555.14 doi: 10.1016/j.jneumeth.2008.05.021 – ident: 2023041304154581000_35.8.3555.37 doi: 10.1016/j.neuroscience.2011.06.070 – ident: 2023041304154581000_35.8.3555.24 doi: 10.1201/9780203735701-46 – ident: 2023041304154581000_35.8.3555.45 doi: 10.1111/j.1749-6632.2001.tb03776.x – ident: 2023041304154581000_35.8.3555.11 doi: 10.1523/JNEUROSCI.1937-09.2009 – volume: 43 start-page: 265.04 year: 2013 ident: 2023041304154581000_35.8.3555.50 article-title: Statistics of natural vestibular stimuli in monkey: implications for coding publication-title: Soc Neurosci Abstr contributor: fullname: Schneider – volume: 82 start-page: 2612 year: 1999 ident: 2023041304154581000_35.8.3555.55 article-title: Quantitative analysis of abducens neuron discharge dynamics during saccadic and slow eye movements publication-title: J Neurophysiol doi: 10.1152/jn.1999.82.5.2612 contributor: fullname: Sylvestre – ident: 2023041304154581000_35.8.3555.19 doi: 10.1007/BF00161093 – ident: 2023041304154581000_35.8.3555.28 doi: 10.1038/nn.2191 – ident: 2023041304154581000_35.8.3555.56 doi: 10.1016/0957-4271(95)02039-X – volume: 22 start-page: RC226 year: 2002 ident: 2023041304154581000_35.8.3555.18 article-title: Semicircular canal afferents similarly encode active and passive head-on-body rotations: implications for the role of vestibular efference publication-title: J Neurosci doi: 10.1523/JNEUROSCI.22-11-j0002.2002 contributor: fullname: Cullen – ident: 2023041304154581000_35.8.3555.46 doi: 10.1523/JNEUROSCI.3988-03.2004 |
SSID | ssj0007017 |
Score | 2.4040596 |
Snippet | Traditionally, the neural encoding of vestibular information is studied by applying either passive rotations or translations in isolation. However, natural... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 3555 |
SubjectTerms | Action Potentials Animals Head Movements Macaca Macaca mulatta Male Otolithic Membrane - physiology Semicircular Canals - physiology Sensory Receptor Cells - physiology Space Perception Vestibular Nuclei - cytology Vestibular Nuclei - physiology |
Title | Integration of canal and otolith inputs by central vestibular neurons is subadditive for both active and passive self-motion: implication for perception |
URI | https://www.ncbi.nlm.nih.gov/pubmed/25716854 https://search.proquest.com/docview/1659765599 https://search.proquest.com/docview/1765982515 https://pubmed.ncbi.nlm.nih.gov/PMC4339360 |
Volume | 35 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEF01PXFBQPlIKdUgIW6O19n1esMtRFR1UUpQKerNste7aqVkEzXOof-En8vMxg4EJA7cImXt2HmT9bzJmzeMvSMbMeeGMuLlyEVSkQigrnXkFPVB2tSJigr600t1fi0vbtKbA5Z2vTBBtG-qu4GfLwb-7jZoK1cLE3c6sXg2nUghRkLxuMd6mRAdRW-334yHMbtIt5AXyUy2bcFIuOKLS5LHXU3yAVU7ooRqKgnNrsG4TZRO5f7D6a-M80_h5G9PorMn7HGbQsJ4e6lP2YH1z9jR2CN9XjzAewiizlAtP2I_8tYOAr9-WDogM4I5lL6GLw0p324h96tNs4bqAdpCL3wn442K5KkQrDv8GvI14A5D2iPaHQETXfiIEMM47JbhfDPMwun1lZ27aBpmA32A_JdePRw028lonrPrs0_fJudRO4whMinnTWStRAw1WU5ZbTGpoK7rkTJI2QTCwQ1ehK3KksZGOER_6NKh5i51dZmUiZPiBTv0S29fMVCJqdPEZpprI0VlK66l4NIYoZWzRvRZ3KFQrLaeGwVxFYSw2EFYEIRIXAqCsM_edmAV-POg_zxKb5ebdZEoZEyKbNX-sQYXjKiFF8_zcgvw7nO7yOizbA_63QKy595_B6M22HS3UXr830e-Zo_o5kIDfXrCDpv7jX2DKVBTnbLe56_6NAT-T9X_B-k |
link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaW5QAXXsujPAcJcUvq1I6TcisVq2bZlkr70N6ixLG1K1q3oulh-SX8XGbcpNBFQoJbpThp3Xx25pt88w1j78hGzNqeDHjRt4FUJAKoqjSwiuogTWxFSQn98USNzuTRRXyxx-K2FsaL9nV5FbrZPHRXl15buZzrbqsT607HQylEXyjevcVu43rtJS1JbzbghPtGu0i4kBnJRDaFwUi5ukcTEsidDLOQ8h1BRFmViLrXIHIjlcZy9_H0R8x5Uzr527Po8D47b2exkaB8Ddd1GervNwwe_3maD9i9JjqFwebwQ7Zn3CN2MHDIzOfX8B68XtQn4g_Yj6xxmsA7CwsL5HMwg8JV8KUmUd0lZG65rldQXkOTQ4Zz8vQoSfkK3hXErSBbAW5eJGuijRcwhoaPiB4Y-I3YX2-KAT59PjEzG4x926EPkP2SwvuTpluFzmN2dvjpdDgKmj4PgY45rwNjJMIjJTcrkxqMV6igu680skGBfwHX-CNMWRTUkcIisHo27qXcxrYqoiKyUjxh-27hzDMGKtJVHJkk5amWojQlT6XgUmuRKmu06LBue3vz5cbOIycahNjIt9jICRvIiXLCRoe9bVGQ48qj1ymFM4v1Ko8UkjFFjm1_GYMD-lQdjNd5ukHO9ntbyHVYsoOp7QBy_t49gkjxDuANMp7_95lv2J3R6fg4P84mn1-wuzRRX6cfv2T79be1eYWRVl2-9uvqJ_ifKOg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nj9MwELVgkRAXvhaW8jlIiFsap3bchFspVJuFlkrLohWXKHFs7YrWrWh6WH4JP5cZNynbReKwt0pxkrp5duZN37xh7A3ZiFnbkwEvUhtIRSKAqkoCq6gO0sRWlJTQH0_U4Yk8Oo1PL7X68qJ9XZ533WzedednXlu5nOuw1YmF0_FQCpEKxcNlZcOb7Bau2V7aEvVmE-5z32wXSReyI9mXTXEw0q7waEIiueNh1qWcRxBRZiWiDjaI3kglsdx9Rf0Td16VT156H43use_tTDYylB_ddV129a8rJo_Xmup9dreJUmGwGfKA3TDuIdsfOGTo8wt4C1436hPy--x31jhO4BOGhQXyO5hB4Sr4UpO47gwyt1zXKygvoMklwzfy9ihJAQveHcStIFsBbmIkb6INGDCWhveIIhj4Ddlfb4qBPn0-NjMbjH37oXeQ_ZXE-5OmW6XOI3Yy-vh1eBg0_R4CHXNeB8ZIhElCrlYmMRi3UGF3qjSyQoE_A9f4JUxZFNSZwiLAejbuJdzGtiqiIrJSPGZ7buHMEwYq0lUcmX7CEy1FaUqeSMGl1iJR1mjRYWH7iPPlxtYjJzqE-Mi3-MgJH8iNcsJHh71ukZDjCqS_VQpnFutVHikkZYqc2_4zBgekVCWM1znYoGd73xZ2HdbfwdV2ADmA7x5BtHgn8AYdT6995it2e_phlH_OJp-esTs0T1-uHz9ne_XPtXmBAVddvvRL6w8vsito |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integration+of+canal+and+otolith+inputs+by+central+vestibular+neurons+is+subadditive+for+both+active+and+passive+self-motion%3A+implication+for+perception&rft.jtitle=The+Journal+of+neuroscience&rft.au=Carriot%2C+Jerome&rft.au=Jamali%2C+Mohsen&rft.au=Brooks%2C+Jessica+X&rft.au=Cullen%2C+Kathleen+E&rft.date=2015-02-25&rft.eissn=1529-2401&rft.volume=35&rft.issue=8&rft.spage=3555&rft_id=info:doi/10.1523%2FJNEUROSCI.3540-14.2015&rft_id=info%3Apmid%2F25716854&rft.externalDocID=25716854 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-6474&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-6474&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-6474&client=summon |