Multi-layered Gag-specific immunodominant responses contribute to improved viral control in the CRF01_AE subtype of HIV-1-infected MSM subjects

• Published in: BMC immunology Vol. 17; no. 1; p. 28
• Main Authors: Jiang, Fanming, Han, Xiaoxu, Zhang, Hui, Zhao, Bin, An, Minghui, Xu, Junjie, Chu, Zhenxing, Dong, Tao, Shang, Hong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.08.2016; BioMed Central
• Subjects: Adult; Cells, Cultured; Cohort Studies; Development and progression; Enzyme-Linked Immunospot Assay; gag Gene Products, Human Immunodeficiency Virus - immunology; Gene mutations; Genetic aspects; Health aspects; HIV infection; HIV Infections - immunology; HIV-1 - physiology; Humans; Immune response; Immunodominant Epitopes - immunology; Interferon-gamma - metabolism; Lymphocyte Activation; Male; Middle Aged; MSM (Men who have sex with men); nef Gene Products, Human Immunodeficiency Virus - immunology; Peptides - immunology; pol Gene Products, Human Immunodeficiency Virus - immunology; Prospective Studies; Sexual and Gender Minorities; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - virology; Viral Load; HIV-1; CTL; Gag; Immunodominant; CRF01_AE

The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtype during the first year of infection and impacts on viral control and evolution. Fifteen HI...