Screening in Planarians Identifies MORN2 as a Key Component in LC3-Associated Phagocytosis and Resistance to Bacterial Infection

• Published in: Cell host & microbe Vol. 16; no. 3; pp. 338 - 350
• Main Authors: Abnave, Prasad, Mottola, Giovanna, Gimenez, Gregory, Boucherit, Nicolas, Trouplin, Virginie, Torre, Cedric, Conti, Filippo, Ben Amara, Amira, Lepolard, Catherine, Djian, Benjamin, Hamaoui, Daniel, Mettouchi, Amel, Kumar, Atul, Pagnotta, Sophie, Bonatti, Stefano, Lepidi, Hubert, Salvetti, Alessandra, Abi-Rached, Laurent, Lemichez, Emmanuel, Mege, Jean-Louis, Ghigo, Eric
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.09.2014; Elsevier
• Subjects: Animals; Bacterial Infections - genetics; Bacterial Infections - immunology; Bacterial Infections - microbiology; Disease Models, Animal; Helminth Proteins - genetics; Helminth Proteins - immunology; Humans; Legionella pneumophila - immunology; Legionella pneumophila - physiology; Life Sciences; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - immunology; Phagocytosis; Planarians - genetics; Planarians - immunology; Planarians - microbiology; Staphylococcus aureus - immunology; Staphylococcus aureus - physiology

Dugesia japonica planarian flatworms are naturally exposed to various microbes but typically survive this challenge. We show that planarians eliminate bacteria pathogenic to Homo sapiens, Caenorhabditis elegans, and/or Drosophila melanogaster and thus represent a model to identify innate resistance...