Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials

• Published in: Amino acids Vol. 45; no. 6; pp. 1273 - 1292
• Main Authors: Molfino, Alessio, Gioia, Gianfranco, Rossi Fanelli, Filippo, Muscaritoli, Maurizio
• Format: Journal Article
• Language: English
• Published: Vienna Springer-Verlag 01.12.2013; Springer Vienna; Springer Nature B.V
• Subjects: Amino acids; Analytical Chemistry; athletes; Atrophy; bariatric surgery; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; Cachexia; Chain branching; chronic diseases; Chronic illnesses; Chronic obstructive pulmonary disease; Clinical trials; Damage prevention; Dietary Supplements; Disease; education programs; Effectiveness; elderly; exercise; Gastrointestinal surgery; Geriatrics; Health; Human immunodeficiency virus; Humans; Leucine; Life Sciences; Lung cancer; Lung diseases; mechanism of action; Metabolites; Muscles; muscular atrophy; Neurobiology; patients; Proteolysis; Proteomics; randomized clinical trials; Randomized Controlled Trials as Topic; Review Article; Supplements; Systematic review; Valerates - administration & dosage; Valerates - pharmacology; Valerates - therapeutic use; Training; Muscle atrophy; Cachexia; Beta-hydroxy-beta-methylbutyrate; Proteolytic pathways

Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the branched-chain amino acid leucine, is extensively used by athletes and bodybuilders in order to increase strength, muscle mass and exercise performance. We performed a systematic review of the clinical literature on the effectiveness of HMB...