Efficacy and Safety of Diquafosol Ophthalmic Solution in Patients with Dry Eye Syndrome: A Japanese Phase 2 Clinical Trial

• Published in: Ophthalmology (Rochester, Minn.) Vol. 119; no. 10; pp. 1954 - 1960
• Main Authors: Matsumoto, Yukihiro, Ohashi, Yuichi, Watanabe, Hitoshi, Tsubota, Kazuo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2012; Elsevier
• Subjects: Administration, Topical; Biological and medical sciences; Cornea - metabolism; Double-Blind Method; Dry Eye Syndromes - drug therapy; Dry Eye Syndromes - metabolism; Female; Fluorophotometry; Humans; Japan; Male; Medical sciences; Middle Aged; Miscellaneous; Ophthalmic Solutions - administration & dosage; Ophthalmic Solutions - adverse effects; Ophthalmology; Polyphosphates - administration & dosage; Polyphosphates - adverse effects; Prospective Studies; Purinergic P2Y Receptor Agonists - administration & dosage; Purinergic P2Y Receptor Agonists - adverse effects; Tears - physiology; Treatment Outcome; Uracil Nucleotides - administration & dosage; Uracil Nucleotides - adverse effects; Japan; Human; Agonist; Toxicity; Diquafosol; Japanese; Eye; Dry eye syndrome; Eye disease; P2Y2 purinergic receptor; Phase II trial; Ophthalmology; Safety; Solution

To investigate the dose-dependent efficacy and safety of diquafosol ophthalmic solution for the treatment of dry eye syndrome. Randomized, double-masked, multicenter, parallel-group, placebo-controlled trial. A total of 286 Japanese patients with dry eye who were prescribed topical diquafosol (1%, n...