Mechanistic insights into the pH-dependent membrane peptide ATRAM

• Published in: Journal of controlled release Vol. 298; pp. 142 - 153
• Main Authors: Nguyen, Vanessa P., Palanikumar, Loganathan, Kennel, Stephen J., Alves, Daiane S., Ye, Yujie, Wall, Jonathan S., Magzoub, Mazin, Barrera, Francisco N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.03.2019
• Subjects: blood; blood flow; cytoplasm; human serum albumin; image analysis; lipid bilayers; lipids; mice; neoplasm cells; neoplasms; oligomerization; peptides; plasma membrane; proteolysis; therapeutics; tissues

pH-responsive peptides are promising therapeutic molecules that can specifically target the plasma membrane in the acidified extracellular medium that bathes cells in tumors. We designed the acidity-triggered rational membrane (ATRAM) peptide to have a pH-responsive membrane interaction. At physiolo...