Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

• Published in: Kidney international Vol. 84; no. 4; pp. 733 - 744
• Main Authors: Gondouin, Bertrand, Cerini, Claire, Dou, Laetitia, Sallée, Marion, Duval-Sabatier, Ariane, Pletinck, Anneleen, Calaf, Raymond, Lacroix, Romaric, Jourde-Chiche, Noémie, Poitevin, Stéphane, Arnaud, Laurent, Vanholder, Raymond, Brunet, Philippe, Dignat-George, Françoise, Burtey, Stéphane
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2013; Elsevier Limited; Nature Publishing Group
• Subjects: Adult; Aged; Aged, 80 and over; aryl hydrocarbon receptor; Benzoquinones - pharmacology; Cardiology and cardiovascular system; Case-Control Studies; Cells, Cultured; Dioxins - pharmacology; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Female; Human health and pathology; Humans; In Vitro Techniques; Indican - metabolism; Indican - pharmacology; Indoleacetic Acids - metabolism; Indoleacetic Acids - pharmacology; Lactams, Macrocyclic - pharmacology; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Life Sciences; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon - antagonists & inhibitors; Receptors, Aryl Hydrocarbon - drug effects; Receptors, Aryl Hydrocarbon - metabolism; Renal Insufficiency, Chronic - metabolism; RNA, Small Interfering - pharmacology; Signal Transduction - drug effects; Signal Transduction - physiology; Thromboplastin - metabolism; Tissue Array Analysis; tissue factor; Umbilical Veins - cytology; Umbilical Veins - drug effects; Umbilical Veins - metabolism; Up-Regulation - drug effects; Up-Regulation - physiology; uremic solutes; Urology and Nephrology; tissue factor; uremic solutes; aryl hydrocarbon receptor

In chronic kidney disease (CKD), uremic solutes accumulate in blood and tissues. These compounds probably contribute to the marked increase in cardiovascular risk during the progression of CKD. The uremic solutes indoxyl sulfate and indole-3-acetic acid (IAA) are particularly deleterious for endothe...