Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain

Abstract One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness. For the treatment of stroke, stimulation of endogenous neural stem/progenitor cells (NSPCs) by growth factors is a promising strategy for tis...

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Published inBiomaterials Vol. 32; no. 24; pp. 5688 - 5697
Main Authors Cooke, Michael J, Wang, Yuanfei, Morshead, Cindi M, Shoichet, Molly S
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.08.2011
Subjects
Advanced Basic Science
Animals
Brain - cytology
Brain - pathology
Cell Proliferation - drug effects
Dentistry
Drug delivery
Epidermal growth factor
Epidermal Growth Factor - chemistry
Epidermal Growth Factor - metabolism
Epidermal Growth Factor - therapeutic use
Hyaluronic Acid - chemistry
Hydrogel
Mice
Mice, Inbred BALB C
Models, Biological
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Peptide Hydrolases - metabolism
Poly(ethylene glycol)
Polyethylene Glycols - chemistry
Stroke
Stroke - drug therapy
Stroke - metabolism
Stroke - therapy
Tissue penetration
Stroke
Drug delivery
Epidermal growth factor
Tissue penetration
Hydrogel
Poly(ethylene glycol)
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Abstract Abstract One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness. For the treatment of stroke, stimulation of endogenous neural stem/progenitor cells (NSPCs) by growth factors is a promising strategy for tissue regeneration. Epidermal growth factor (EGF) enhances proliferation of endogenous NSPCs in the subventricular zone (SVZ) when delivered directly to the ventricles of the brain; however, this strategy is highly invasive. We designed a biomaterials-based strategy to deliver molecules directly to the brain without tissue damage. EGF or poly(ethylene glycol)-modified EGF (PEG-EGF) was dispersed in a hyaluronan and methylcellulose (HAMC) hydrogel and placed epi-cortically on both uninjured and stroke-injured mouse brains. PEG-modification decreased the rate of EGF degradation by proteases, leading to a significant increase in protein accumulation at greater tissue depths than previously shown. Consequently, EGF and PEG-EGF increased NSPC proliferation in uninjured and stroke-injured brains; and in stroke-injured brains, PEG-EGF significantly increased NSPC stimulation. Our epi-cortical delivery system is a minimally-invasive method for local delivery to the brain, providing a new paradigm for local delivery to the brain.
AbstractList One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness. For the treatment of stroke, stimulation of endogenous neural stem/progenitor cells (NSPCs) by growth factors is a promising strategy for tissue regeneration. Epidermal growth factor (EGF) enhances proliferation of endogenous NSPCs in the subventricular zone (SVZ) when delivered directly to the ventricles of the brain; however, this strategy is highly invasive. We designed a biomaterials-based strategy to deliver molecules directly to the brain without tissue damage. EGF or poly(ethylene glycol)-modified EGF (PEG-EGF) was dispersed in a hyaluronan and methylcellulose (HAMC) hydrogel and placed epi-cortically on both uninjured and stroke-injured mouse brains. PEG-modification decreased the rate of EGF degradation by proteases, leading to a significant increase in protein accumulation at greater tissue depths than previously shown. Consequently, EGF and PEG-EGF increased NSPC proliferation in uninjured and stroke-injured brains; and in stroke-injured brains, PEG-EGF significantly increased NSPC stimulation. Our epi-cortical delivery system is a minimally-invasive method for local delivery to the brain, providing a new paradigm for local delivery to the brain.
Abstract One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness. For the treatment of stroke, stimulation of endogenous neural stem/progenitor cells (NSPCs) by growth factors is a promising strategy for tissue regeneration. Epidermal growth factor (EGF) enhances proliferation of endogenous NSPCs in the subventricular zone (SVZ) when delivered directly to the ventricles of the brain; however, this strategy is highly invasive. We designed a biomaterials-based strategy to deliver molecules directly to the brain without tissue damage. EGF or poly(ethylene glycol)-modified EGF (PEG-EGF) was dispersed in a hyaluronan and methylcellulose (HAMC) hydrogel and placed epi-cortically on both uninjured and stroke-injured mouse brains. PEG-modification decreased the rate of EGF degradation by proteases, leading to a significant increase in protein accumulation at greater tissue depths than previously shown. Consequently, EGF and PEG-EGF increased NSPC proliferation in uninjured and stroke-injured brains; and in stroke-injured brains, PEG-EGF significantly increased NSPC stimulation. Our epi-cortical delivery system is a minimally-invasive method for local delivery to the brain, providing a new paradigm for local delivery to the brain.
Author Cooke, Michael J
Morshead, Cindi M
Shoichet, Molly S
Wang, Yuanfei
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21550655$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1073/pnas.96.8.4536
10.1016/0009-2509(91)80036-X
10.1088/0034-4885/64/7/202
10.1038/sj.jcbfm.9600402
10.1523/JNEUROSCI.10-03-00909.1990
10.1046/j.1365-2125.2003.01939.x
10.1523/JNEUROSCI.2751-04.2004
10.1007/BF00237878
10.1161/STROKEAHA.107.482877
10.1172/JCI200317170
10.1002/btpr.296
10.1016/j.jneumeth.2009.04.009
10.1002/jps.21297
10.1002/jnr.10270
10.1016/0006-8993(96)00378-2
10.2165/00003088-200746070-00002
10.1111/j.1471-4159.1984.tb12739.x
10.1098/rstb.2006.2016
10.1016/j.jconrel.2010.01.029
10.1016/S1461-5347(98)00086-8
10.1016/S0092-8674(00)80783-7
10.1016/S0896-6273(02)01133-9
10.3171/FOC.2008.25.11.E14
10.1073/pnas.0603512103
10.1016/j.jconrel.2010.10.022
10.1016/j.jconrel.2009.05.009
10.1016/j.biomaterials.2005.11.015
10.1007/BF00217193
10.1002/jnr.10670
10.1089/089771504322972077
10.1016/j.ces.2005.04.040
10.1212/WNL.0b013e3181cbccec
10.1023/A:1018824324275
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Issue 24
Keywords Stroke
Drug delivery
Epidermal growth factor
Tissue penetration
Hydrogel
Poly(ethylene glycol)
Language English
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References Doetsch, Petreanu, Caille, Garcia-Verdugo, Alvarez-Buylla (bib31) 2002; 36
Novaes, Mazzola, Pessoa, Penna (bib38) 2010; 26
Saltzman (bib33) 1997; 10
Doetsch, Caille, Lim, Garcia-Verdugo, Alvarez-Buylla (bib9) 1999; 97
Bear, Kleinschmidt, Gu, Singer (bib2) 1990; 10
Kolb, Morshead, Gonzalez, Kim, Gregg, Shingo (bib7) 2007; 27
Jablonska, Gierdalski, Kublik, Skangiel-Kramska, Kossut (bib1) 1993; 53
Paradiso, Bear, Daniels (bib3) 1983; 51
Shashoua, Hesse, Moore (bib23) 1984; 42
Heiss, Walbridge, Asthagiri, Lonser (bib41) 2010; 112
Bakhshi, North (bib40) 1995; 26
Salman, Ghosh, Kernie (bib10) 2004; 21
Jin, Wang, Xie, Mao, Zhu, Wang (bib12) 2006; 103
Tennant, Jones (bib22) 2009; 181
Lo, Wang, Cuzner (bib28) 2002; 69
Marti-Fabregas, Romaguera-Ros, Gomez-Pinedo, Martinez-Ramirez, Jimenez-Xarrie, Marin (bib13) 2010; 74
Ford, Bryant, Mangoni, Jackson (bib6) 2004; 57
Teramoto, Qu, Plumier, Moskowitz (bib14) 2003; 111
Bouab, Paliouras, Aumont, Forest-Bérard, Fernandes (bib30) 2010; 173
Mahoney, Saltzman (bib36) 1999; 96
Sprigg, Bath (bib16) 2007; 38
Franklin, Paxinos (bib20) 2008
Saltzman, Mak, Mahoney, Duenas, Cleland (bib34) 1999; 16
Saltzman, Radomsky (bib27) 1991; 46
Riquelme, Drapeau, Doetsch (bib11) 2008; 363
Bailon, Berthold (bib25) 1998; 1
Kalluri, Dempsey (bib15) 2008; 24
Baumann, Kang, Stanwick, Wang, Kim, Lapitsky (bib37) 2009; 138
Wang, Cooke, Lapitsky, Wylie, Sachewsky, Corbett (bib21) 2011; 149
Lin, Meng, Zhong, Li, Du, Tomasik (bib24) 2008; 97
Erlandsson A, Lin A, Yu F, Morshead CM, Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury. Exp Neurol, in press.
Fee, Van Alstine (bib26) 2006; 61
de Boer, Gaillard (bib4) 2007; 46
Kang, Tator, Shoichet (bib18) 2010; 144
Nicholson (bib19) 2001; 64
Hawryluk, Rowland, Kwon, Fehlings (bib32) 2008; 25
Enwere, Shingo, Gregg, Fujikawa, Ohta, Weiss (bib29) 2004; 24
Felling, Levison (bib39) 2003; 73
Gupta, Tator, Shoichet (bib17) 2006; 27
Nave, Probstmeier, Schachner (bib5) 1985; 241
Krewson, Saltzman (bib35) 1996; 727
Lo (10.1016/j.biomaterials.2011.04.032_bib28) 2002; 69
Nave (10.1016/j.biomaterials.2011.04.032_bib5) 1985; 241
Lin (10.1016/j.biomaterials.2011.04.032_bib24) 2008; 97
Bouab (10.1016/j.biomaterials.2011.04.032_bib30) 2010; 173
Saltzman (10.1016/j.biomaterials.2011.04.032_bib27) 1991; 46
Tennant (10.1016/j.biomaterials.2011.04.032_bib22) 2009; 181
Doetsch (10.1016/j.biomaterials.2011.04.032_bib31) 2002; 36
Salman (10.1016/j.biomaterials.2011.04.032_bib10) 2004; 21
Novaes (10.1016/j.biomaterials.2011.04.032_bib38) 2010; 26
Kalluri (10.1016/j.biomaterials.2011.04.032_bib15) 2008; 24
Shashoua (10.1016/j.biomaterials.2011.04.032_bib23) 1984; 42
Kang (10.1016/j.biomaterials.2011.04.032_bib18) 2010; 144
Sprigg (10.1016/j.biomaterials.2011.04.032_bib16) 2007; 38
Felling (10.1016/j.biomaterials.2011.04.032_bib39) 2003; 73
Paradiso (10.1016/j.biomaterials.2011.04.032_bib3) 1983; 51
Riquelme (10.1016/j.biomaterials.2011.04.032_bib11) 2008; 363
de Boer (10.1016/j.biomaterials.2011.04.032_bib4) 2007; 46
Mahoney (10.1016/j.biomaterials.2011.04.032_bib36) 1999; 96
Baumann (10.1016/j.biomaterials.2011.04.032_bib37) 2009; 138
Jin (10.1016/j.biomaterials.2011.04.032_bib12) 2006; 103
Bakhshi (10.1016/j.biomaterials.2011.04.032_bib40) 1995; 26
10.1016/j.biomaterials.2011.04.032_bib8
Franklin (10.1016/j.biomaterials.2011.04.032_bib20) 2008
Nicholson (10.1016/j.biomaterials.2011.04.032_bib19) 2001; 64
Hawryluk (10.1016/j.biomaterials.2011.04.032_bib32) 2008; 25
Wang (10.1016/j.biomaterials.2011.04.032_bib21) 2011; 149
Marti-Fabregas (10.1016/j.biomaterials.2011.04.032_bib13) 2010; 74
Heiss (10.1016/j.biomaterials.2011.04.032_bib41) 2010; 112
Kolb (10.1016/j.biomaterials.2011.04.032_bib7) 2007; 27
Enwere (10.1016/j.biomaterials.2011.04.032_bib29) 2004; 24
Jablonska (10.1016/j.biomaterials.2011.04.032_bib1) 1993; 53
Teramoto (10.1016/j.biomaterials.2011.04.032_bib14) 2003; 111
Doetsch (10.1016/j.biomaterials.2011.04.032_bib9) 1999; 97
Fee (10.1016/j.biomaterials.2011.04.032_bib26) 2006; 61
Krewson (10.1016/j.biomaterials.2011.04.032_bib35) 1996; 727
Bailon (10.1016/j.biomaterials.2011.04.032_bib25) 1998; 1
Saltzman (10.1016/j.biomaterials.2011.04.032_bib33) 1997; 10
Ford (10.1016/j.biomaterials.2011.04.032_bib6) 2004; 57
Bear (10.1016/j.biomaterials.2011.04.032_bib2) 1990; 10
Saltzman (10.1016/j.biomaterials.2011.04.032_bib34) 1999; 16
Gupta (10.1016/j.biomaterials.2011.04.032_bib17) 2006; 27
References_xml – volume: 73
  start-page: 277
  year: 2003
  end-page: 283
  ident: bib39
  article-title: Enhanced neurogenesis following stroke
  publication-title: J Neurosci Res
  contributor:
    fullname: Levison
– volume: 144
  start-page: 25
  year: 2010
  end-page: 31
  ident: bib18
  article-title: Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system
  publication-title: J Controlled Release
  contributor:
    fullname: Shoichet
– volume: 24
  start-page: 8354
  year: 2004
  end-page: 8365
  ident: bib29
  article-title: Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination
  publication-title: J Neurosci
  contributor:
    fullname: Weiss
– volume: 10
  start-page: 78
  year: 1997
  end-page: 83
  ident: bib33
  article-title: Biomaterials for drug delivery to the brain
  publication-title: Protein Eng
  contributor:
    fullname: Saltzman
– volume: 181
  start-page: 18
  year: 2009
  end-page: 26
  ident: bib22
  article-title: Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in c57bl/6 mice
  publication-title: J Neurosci Method
  contributor:
    fullname: Jones
– volume: 36
  start-page: 1021
  year: 2002
  end-page: 1034
  ident: bib31
  article-title: Egf converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
  publication-title: Neuron
  contributor:
    fullname: Alvarez-Buylla
– volume: 21
  start-page: 283
  year: 2004
  end-page: 292
  ident: bib10
  article-title: Subventricular Zone Neural Stem Cells Remodel the Brain following Traumatic Injury in Adult Mice
  publication-title: J Neurotrauma
  contributor:
    fullname: Kernie
– volume: 1
  start-page: 352
  year: 1998
  end-page: 356
  ident: bib25
  article-title: Polyethylene glycol-conjugated pharmaceutical proteins
  publication-title: Pharm Sci Technol Today
  contributor:
    fullname: Berthold
– volume: 27
  start-page: 2370
  year: 2006
  end-page: 2379
  ident: bib17
  article-title: Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
  publication-title: Biomaterials
  contributor:
    fullname: Shoichet
– volume: 74
  start-page: 357
  year: 2010
  end-page: 365
  ident: bib13
  article-title: Proliferation in the human ipsilateral subventricular zone after ischemic stroke
  publication-title: Neurology
  contributor:
    fullname: Marin
– volume: 38
  start-page: 1997
  year: 2007
  end-page: 1998
  ident: bib16
  article-title: Colony stimulating factors (blood growth factors) are promising but unproven for treating stroke
  publication-title: Stroke
  contributor:
    fullname: Bath
– volume: 26
  start-page: 252
  year: 2010
  end-page: 256
  ident: bib38
  article-title: Effect of polyethylene glycol on the thermal stability of green fluorescent protein
  publication-title: Biotechnol Prog
  contributor:
    fullname: Penna
– volume: 96
  start-page: 4536
  year: 1999
  end-page: 4539
  ident: bib36
  article-title: Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Saltzman
– volume: 53
  start-page: 577
  year: 1993
  end-page: 580
  ident: bib1
  article-title: Effects of implantation of alzet 1007d osmotic minipumps upon 2-deoxyglucose uptake in the cerebral cortex of mice
  publication-title: Acta Neurobiol Exp
  contributor:
    fullname: Kossut
– volume: 111
  start-page: 1125
  year: 2003
  end-page: 1132
  ident: bib14
  article-title: Egf amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia
  publication-title: J Clin Invest
  contributor:
    fullname: Moskowitz
– volume: 46
  start-page: 2429
  year: 1991
  end-page: 2444
  ident: bib27
  article-title: Drugs released from polymers - diffusion and elimination in brain-tissue
  publication-title: Chem Eng Sci
  contributor:
    fullname: Radomsky
– volume: 173
  start-page: 135
  year: 2010
  end-page: 149
  ident: bib30
  article-title: Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood
  publication-title: J Neurosci
  contributor:
    fullname: Fernandes
– volume: 727
  start-page: 169
  year: 1996
  end-page: 181
  ident: bib35
  article-title: Transport and elimination of recombinant human ngf during long-term delivery to the brain
  publication-title: Brain Res
  contributor:
    fullname: Saltzman
– volume: 27
  start-page: 983
  year: 2007
  end-page: 997
  ident: bib7
  article-title: Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats
  publication-title: J Cerebr Blood F Met
  contributor:
    fullname: Shingo
– volume: 46
  start-page: 553
  year: 2007
  end-page: 576
  ident: bib4
  article-title: Strategies to improve drug delivery across the blood-brain barrier
  publication-title: Clin Pharmacokinet
  contributor:
    fullname: Gaillard
– volume: 69
  start-page: 1
  year: 2002
  end-page: 9
  ident: bib28
  article-title: Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases
  publication-title: J Neurosci Res
  contributor:
    fullname: Cuzner
– volume: 16
  start-page: 232
  year: 1999
  end-page: 240
  ident: bib34
  article-title: Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systems
  publication-title: Pharmaceut Res
  contributor:
    fullname: Cleland
– volume: 103
  start-page: 13198
  year: 2006
  end-page: 13202
  ident: bib12
  article-title: Evidence for stroke-induced neurogenesis in the human brain
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Wang
– volume: 26
  start-page: 133
  year: 1995
  end-page: 139
  ident: bib40
  article-title: Implantable pumps for drug delivery to the brain
  publication-title: J Neuro-Oncol
  contributor:
    fullname: North
– volume: 61
  start-page: 924
  year: 2006
  end-page: 939
  ident: bib26
  article-title: Peg-proteins: reaction engineering and separation issues
  publication-title: Chem Eng Sci
  contributor:
    fullname: Van Alstine
– volume: 97
  start-page: 4240
  year: 2008
  end-page: 4248
  ident: bib24
  article-title: Novel biodegradable blend matrices for controlled drug release
  publication-title: J Pharm Sci
  contributor:
    fullname: Tomasik
– year: 2008
  ident: bib20
  article-title: The jouse brain in stereotaic coordinates
  contributor:
    fullname: Paxinos
– volume: 149
  start-page: 225
  year: 2011
  end-page: 235
  ident: bib21
  article-title: Transport of epidermal growth factor in the stroke-injured brain
  publication-title: J Control Release
  contributor:
    fullname: Corbett
– volume: 42
  start-page: 1536
  year: 1984
  end-page: 1541
  ident: bib23
  article-title: Proteins of the brain extracellular fluid - evidence for release of s-100 protein
  publication-title: J Neurochem
  contributor:
    fullname: Moore
– volume: 51
  start-page: 413
  year: 1983
  end-page: 422
  ident: bib3
  article-title: Effects of intracortical infusion of 6-hydroxydopamine on the response of kitten visual-cortex to monocular deprivation
  publication-title: Exp Brain Res
  contributor:
    fullname: Daniels
– volume: 363
  start-page: 123
  year: 2008
  end-page: 137
  ident: bib11
  article-title: Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
  publication-title: Philos T R Soc B
  contributor:
    fullname: Doetsch
– volume: 64
  start-page: 815
  year: 2001
  end-page: 884
  ident: bib19
  article-title: Diffusion and related transport mechanisms in brain tissue
  publication-title: Rep Prog Phys
  contributor:
    fullname: Nicholson
– volume: 138
  start-page: 205
  year: 2009
  end-page: 213
  ident: bib37
  article-title: An injectable drug delivery platform for sustained combination therapy
  publication-title: J Control Release
  contributor:
    fullname: Lapitsky
– volume: 241
  start-page: 453
  year: 1985
  end-page: 457
  ident: bib5
  article-title: Epidermal growth-factor does not cross the blood-brain-barrier
  publication-title: Cell Tissue Res
  contributor:
    fullname: Schachner
– volume: 97
  start-page: 703
  year: 1999
  end-page: 716
  ident: bib9
  article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
  publication-title: Cell
  contributor:
    fullname: Alvarez-Buylla
– volume: 25
  start-page: E14
  year: 2008
  ident: bib32
  article-title: Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury
  publication-title: Neurosurg Focus
  contributor:
    fullname: Fehlings
– volume: 112
  start-page: 790
  year: 2010
  end-page: 795
  ident: bib41
  article-title: Image-guided convection-enhanced delivery of muscimol to the primate brain laboratory investigation
  publication-title: J Neurosurg
  contributor:
    fullname: Lonser
– volume: 10
  start-page: 909
  year: 1990
  end-page: 925
  ident: bib2
  article-title: Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an nmda receptor antagonist
  publication-title: J Neurosci
  contributor:
    fullname: Singer
– volume: 57
  start-page: 15
  year: 2004
  end-page: 26
  ident: bib6
  article-title: Stroke, dementia, and drug delivery
  publication-title: Brit J Clin Pharmaco
  contributor:
    fullname: Jackson
– volume: 24
  year: 2008
  ident: bib15
  article-title: Growth factors, stem cells, and stroke
  publication-title: Neurosurg Focus
  contributor:
    fullname: Dempsey
– volume: 96
  start-page: 4536
  issue: 8
  year: 1999
  ident: 10.1016/j.biomaterials.2011.04.032_bib36
  article-title: Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.96.8.4536
  contributor:
    fullname: Mahoney
– volume: 46
  start-page: 2429
  issue: 10
  year: 1991
  ident: 10.1016/j.biomaterials.2011.04.032_bib27
  article-title: Drugs released from polymers - diffusion and elimination in brain-tissue
  publication-title: Chem Eng Sci
  doi: 10.1016/0009-2509(91)80036-X
  contributor:
    fullname: Saltzman
– volume: 64
  start-page: 815
  issue: 7
  year: 2001
  ident: 10.1016/j.biomaterials.2011.04.032_bib19
  article-title: Diffusion and related transport mechanisms in brain tissue
  publication-title: Rep Prog Phys
  doi: 10.1088/0034-4885/64/7/202
  contributor:
    fullname: Nicholson
– volume: 27
  start-page: 983
  issue: 5
  year: 2007
  ident: 10.1016/j.biomaterials.2011.04.032_bib7
  article-title: Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats
  publication-title: J Cerebr Blood F Met
  doi: 10.1038/sj.jcbfm.9600402
  contributor:
    fullname: Kolb
– volume: 24
  issue: 3–4
  year: 2008
  ident: 10.1016/j.biomaterials.2011.04.032_bib15
  article-title: Growth factors, stem cells, and stroke
  publication-title: Neurosurg Focus
  contributor:
    fullname: Kalluri
– volume: 10
  start-page: 909
  issue: 3
  year: 1990
  ident: 10.1016/j.biomaterials.2011.04.032_bib2
  article-title: Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an nmda receptor antagonist
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-03-00909.1990
  contributor:
    fullname: Bear
– volume: 57
  start-page: 15
  issue: 1
  year: 2004
  ident: 10.1016/j.biomaterials.2011.04.032_bib6
  article-title: Stroke, dementia, and drug delivery
  publication-title: Brit J Clin Pharmaco
  doi: 10.1046/j.1365-2125.2003.01939.x
  contributor:
    fullname: Ford
– volume: 24
  start-page: 8354
  issue: 38
  year: 2004
  ident: 10.1016/j.biomaterials.2011.04.032_bib29
  article-title: Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2751-04.2004
  contributor:
    fullname: Enwere
– volume: 26
  start-page: 133
  issue: 2
  year: 1995
  ident: 10.1016/j.biomaterials.2011.04.032_bib40
  article-title: Implantable pumps for drug delivery to the brain
  publication-title: J Neuro-Oncol
  contributor:
    fullname: Bakhshi
– volume: 51
  start-page: 413
  issue: 3
  year: 1983
  ident: 10.1016/j.biomaterials.2011.04.032_bib3
  article-title: Effects of intracortical infusion of 6-hydroxydopamine on the response of kitten visual-cortex to monocular deprivation
  publication-title: Exp Brain Res
  doi: 10.1007/BF00237878
  contributor:
    fullname: Paradiso
– volume: 38
  start-page: 1997
  issue: 6
  year: 2007
  ident: 10.1016/j.biomaterials.2011.04.032_bib16
  article-title: Colony stimulating factors (blood growth factors) are promising but unproven for treating stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.482877
  contributor:
    fullname: Sprigg
– volume: 111
  start-page: 1125
  issue: 8
  year: 2003
  ident: 10.1016/j.biomaterials.2011.04.032_bib14
  article-title: Egf amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia
  publication-title: J Clin Invest
  doi: 10.1172/JCI200317170
  contributor:
    fullname: Teramoto
– volume: 10
  start-page: 78
  issue: 1
  year: 1997
  ident: 10.1016/j.biomaterials.2011.04.032_bib33
  article-title: Biomaterials for drug delivery to the brain
  publication-title: Protein Eng
  contributor:
    fullname: Saltzman
– volume: 26
  start-page: 252
  issue: 1
  year: 2010
  ident: 10.1016/j.biomaterials.2011.04.032_bib38
  article-title: Effect of polyethylene glycol on the thermal stability of green fluorescent protein
  publication-title: Biotechnol Prog
  doi: 10.1002/btpr.296
  contributor:
    fullname: Novaes
– volume: 181
  start-page: 18
  issue: 1
  year: 2009
  ident: 10.1016/j.biomaterials.2011.04.032_bib22
  article-title: Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in c57bl/6 mice
  publication-title: J Neurosci Method
  doi: 10.1016/j.jneumeth.2009.04.009
  contributor:
    fullname: Tennant
– volume: 97
  start-page: 4240
  issue: 10
  year: 2008
  ident: 10.1016/j.biomaterials.2011.04.032_bib24
  article-title: Novel biodegradable blend matrices for controlled drug release
  publication-title: J Pharm Sci
  doi: 10.1002/jps.21297
  contributor:
    fullname: Lin
– volume: 69
  start-page: 1
  issue: 1
  year: 2002
  ident: 10.1016/j.biomaterials.2011.04.032_bib28
  article-title: Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.10270
  contributor:
    fullname: Lo
– volume: 727
  start-page: 169
  issue: 1–2
  year: 1996
  ident: 10.1016/j.biomaterials.2011.04.032_bib35
  article-title: Transport and elimination of recombinant human ngf during long-term delivery to the brain
  publication-title: Brain Res
  doi: 10.1016/0006-8993(96)00378-2
  contributor:
    fullname: Krewson
– volume: 46
  start-page: 553
  issue: 7
  year: 2007
  ident: 10.1016/j.biomaterials.2011.04.032_bib4
  article-title: Strategies to improve drug delivery across the blood-brain barrier
  publication-title: Clin Pharmacokinet
  doi: 10.2165/00003088-200746070-00002
  contributor:
    fullname: de Boer
– volume: 112
  start-page: 790
  issue: 4
  year: 2010
  ident: 10.1016/j.biomaterials.2011.04.032_bib41
  article-title: Image-guided convection-enhanced delivery of muscimol to the primate brain laboratory investigation
  publication-title: J Neurosurg
  contributor:
    fullname: Heiss
– volume: 42
  start-page: 1536
  issue: 6
  year: 1984
  ident: 10.1016/j.biomaterials.2011.04.032_bib23
  article-title: Proteins of the brain extracellular fluid - evidence for release of s-100 protein
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1984.tb12739.x
  contributor:
    fullname: Shashoua
– volume: 363
  start-page: 123
  issue: 1489
  year: 2008
  ident: 10.1016/j.biomaterials.2011.04.032_bib11
  article-title: Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
  publication-title: Philos T R Soc B
  doi: 10.1098/rstb.2006.2016
  contributor:
    fullname: Riquelme
– volume: 144
  start-page: 25
  issue: 1
  year: 2010
  ident: 10.1016/j.biomaterials.2011.04.032_bib18
  article-title: Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system
  publication-title: J Controlled Release
  doi: 10.1016/j.jconrel.2010.01.029
  contributor:
    fullname: Kang
– volume: 1
  start-page: 352
  issue: 8
  year: 1998
  ident: 10.1016/j.biomaterials.2011.04.032_bib25
  article-title: Polyethylene glycol-conjugated pharmaceutical proteins
  publication-title: Pharm Sci Technol Today
  doi: 10.1016/S1461-5347(98)00086-8
  contributor:
    fullname: Bailon
– volume: 173
  start-page: 135
  issue: 26
  year: 2010
  ident: 10.1016/j.biomaterials.2011.04.032_bib30
  article-title: Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood
  publication-title: J Neurosci
  contributor:
    fullname: Bouab
– volume: 97
  start-page: 703
  issue: 6
  year: 1999
  ident: 10.1016/j.biomaterials.2011.04.032_bib9
  article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80783-7
  contributor:
    fullname: Doetsch
– volume: 36
  start-page: 1021
  issue: 6
  year: 2002
  ident: 10.1016/j.biomaterials.2011.04.032_bib31
  article-title: Egf converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)01133-9
  contributor:
    fullname: Doetsch
– volume: 25
  start-page: E14
  issue: 5
  year: 2008
  ident: 10.1016/j.biomaterials.2011.04.032_bib32
  article-title: Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury
  publication-title: Neurosurg Focus
  doi: 10.3171/FOC.2008.25.11.E14
  contributor:
    fullname: Hawryluk
– volume: 103
  start-page: 13198
  issue: 35
  year: 2006
  ident: 10.1016/j.biomaterials.2011.04.032_bib12
  article-title: Evidence for stroke-induced neurogenesis in the human brain
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0603512103
  contributor:
    fullname: Jin
– volume: 149
  start-page: 225
  issue: 3
  year: 2011
  ident: 10.1016/j.biomaterials.2011.04.032_bib21
  article-title: Transport of epidermal growth factor in the stroke-injured brain
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2010.10.022
  contributor:
    fullname: Wang
– volume: 138
  start-page: 205
  issue: 3
  year: 2009
  ident: 10.1016/j.biomaterials.2011.04.032_bib37
  article-title: An injectable drug delivery platform for sustained combination therapy
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2009.05.009
  contributor:
    fullname: Baumann
– volume: 27
  start-page: 2370
  issue: 11
  year: 2006
  ident: 10.1016/j.biomaterials.2011.04.032_bib17
  article-title: Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2005.11.015
  contributor:
    fullname: Gupta
– volume: 241
  start-page: 453
  issue: 2
  year: 1985
  ident: 10.1016/j.biomaterials.2011.04.032_bib5
  article-title: Epidermal growth-factor does not cross the blood-brain-barrier
  publication-title: Cell Tissue Res
  doi: 10.1007/BF00217193
  contributor:
    fullname: Nave
– ident: 10.1016/j.biomaterials.2011.04.032_bib8
– volume: 73
  start-page: 277
  issue: 3
  year: 2003
  ident: 10.1016/j.biomaterials.2011.04.032_bib39
  article-title: Enhanced neurogenesis following stroke
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.10670
  contributor:
    fullname: Felling
– volume: 21
  start-page: 283
  issue: 3
  year: 2004
  ident: 10.1016/j.biomaterials.2011.04.032_bib10
  article-title: Subventricular Zone Neural Stem Cells Remodel the Brain following Traumatic Injury in Adult Mice
  publication-title: J Neurotrauma
  doi: 10.1089/089771504322972077
  contributor:
    fullname: Salman
– year: 2008
  ident: 10.1016/j.biomaterials.2011.04.032_bib20
  contributor:
    fullname: Franklin
– volume: 53
  start-page: 577
  year: 1993
  ident: 10.1016/j.biomaterials.2011.04.032_bib1
  article-title: Effects of implantation of alzet 1007d osmotic minipumps upon 2-deoxyglucose uptake in the cerebral cortex of mice
  publication-title: Acta Neurobiol Exp
  contributor:
    fullname: Jablonska
– volume: 61
  start-page: 924
  issue: 3
  year: 2006
  ident: 10.1016/j.biomaterials.2011.04.032_bib26
  article-title: Peg-proteins: reaction engineering and separation issues
  publication-title: Chem Eng Sci
  doi: 10.1016/j.ces.2005.04.040
  contributor:
    fullname: Fee
– volume: 74
  start-page: 357
  issue: 5
  year: 2010
  ident: 10.1016/j.biomaterials.2011.04.032_bib13
  article-title: Proliferation in the human ipsilateral subventricular zone after ischemic stroke
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3181cbccec
  contributor:
    fullname: Marti-Fabregas
– volume: 16
  start-page: 232
  issue: 2
  year: 1999
  ident: 10.1016/j.biomaterials.2011.04.032_bib34
  article-title: Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systems
  publication-title: Pharmaceut Res
  doi: 10.1023/A:1018824324275
  contributor:
    fullname: Saltzman
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Snippet Abstract One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness....
One of the challenges in treating central nervous system (CNS) disorders with biomolecules is achieving local delivery while minimizing invasiveness. For the...
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SubjectTerms Advanced Basic Science
Animals
Brain - cytology
Brain - pathology
Cell Proliferation - drug effects
Dentistry
Drug delivery
Epidermal growth factor
Epidermal Growth Factor - chemistry
Epidermal Growth Factor - metabolism
Epidermal Growth Factor - therapeutic use
Hyaluronic Acid - chemistry
Hydrogel
Mice
Mice, Inbred BALB C
Models, Biological
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Peptide Hydrolases - metabolism
Poly(ethylene glycol)
Polyethylene Glycols - chemistry
Stroke
Stroke - drug therapy
Stroke - metabolism
Stroke - therapy
Tissue penetration
Title Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0142961211004273
https://dx.doi.org/10.1016/j.biomaterials.2011.04.032
https://www.ncbi.nlm.nih.gov/pubmed/21550655
https://search.proquest.com/docview/870551902
Volume 32
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