Regulation of affect by the lateral septum: implications for neuropsychiatry

• Published in: Brain Research Reviews Vol. 46; no. 1; pp. 71 - 117
• Main Authors: Sheehan, Teige P, Chambers, R.Andrew, Russell, David S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.08.2004; Elsevier
• Subjects: Anatomical correlates of behavior; Animals; Behavioral psychophysiology; Biological and medical sciences; Cell signaling; Depression; Fear and anxiety; Fundamental and applied biological sciences. Psychology; Humans; Mental Disorders - physiopathology; Motivation; Neuroanatomy; Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychosis; Septum of Brain - anatomy & histology; Septum of Brain - physiology; Psychosis; Motivation; Neuroanatomy; Depression; Neural basis of behavior; Fear and anxiety; Cell signaling; Mood disorder; Affect affectivity; Lateral nucleus; Septum nucleus; Central nervous system; Review; Encephalon; Signal transduction; Anxiety

Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating processes related to mood and motivation. This review presents findings from the basic neuroscience literature and from some clinically oriented research, drawing from behavioral, neuroanatomical, electro...