ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection

• Published in: The Journal of clinical investigation Vol. 132; no. 3; pp. 1 - 15
• Main Authors: Zhao, Dianyuan, Yang, Fengjiao, Wang, Yang, Li, Site, Li, Yang, Hou, Fei, Yang, Wenting, Liu, Di, Tao, Yuandong, Li, Qian, Wang, Jing, He, Fuchu, Tang, Li
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.02.2022
• Subjects: Activin; Activin Receptors, Type II - genetics; Activin Receptors, Type II - metabolism; Animals; Bacteria; Bacterial infections; Biomedical research; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Flow cytometry; Gene expression; Genomics; Genotype & phenotype; Growth Differentiation Factor 2 - genetics; Growth Differentiation Factor 2 - metabolism; Growth factor receptors; Health aspects; Homeostasis; Hypotheses; Immune response; Immune system; Immunology; Kinases; Kupffer cells; Kupffer Cells - enzymology; Listeria; Listeria monocytogenes; Listeria monocytogenes - metabolism; Listeriosis - enzymology; Listeriosis - genetics; Listeriosis - prevention & control; Liver; Macrophages; Mice; Mice, Knockout; Monocytes; Phenotypes; Physiological aspects; Prevention; Signal Transduction; Smad4 protein; Spleen; Zonation; China; Macrophages; Immunology

Macrophages are highly heterogeneous immune cells that fulfill tissue-specific functions. Tissue-derived signals play a critical role in determining macrophage heterogeneity. However, these signals remain largely unknown. The BMP receptor activin receptor-like kinase 1 (ALK1) is well known for its r...