Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

• Published in: Science translational medicine Vol. 3; no. 81; p. 81ra36
• Main Authors: Letvin, Norman L, Rao, Srinivas S, Montefiori, David C, Seaman, Michael S, Sun, Yue, Lim, So-Yon, Yeh, Wendy W, Asmal, Mohammed, Gelman, Rebecca S, Shen, Ling, Whitney, James B, Seoighe, Cathal, Lacerda, Miguel, Keating, Sheila, Norris, Philip J, Hudgens, Michael G, Gilbert, Peter B, Buzby, Adam P, Mach, Linh V, Zhang, Jinrong, Balachandran, Harikrishnan, Shaw, George M, Schmidt, Stephen D, Todd, John-Paul, Dodson, Alan, Mascola, John R, Nabel, Gary J
• Format: Journal Article
• Language: English
• Published: United States 04.05.2011
• Subjects: Alleles; Animals; Carrier Proteins - genetics; CD4-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - metabolism; Haplorhini; Humans; Mucous Membrane - virology; Simian Immunodeficiency Virus - pathogenicity

The RV144 vaccine trial in Thailand demonstrated that an HIV vaccine could prevent infection in humans and highlights the importance of understanding protective immunity against HIV. We used a nonhuman primate model to define immune and genetic mechanisms of protection against mucosal infection by t...